ZMYM2 - zinc finger MYM-type containing 2 Gene

Also Known as FIM; MYM; RAMP; SCLL; NECRC; ZNF198

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7750

About ZMYM2

Cytogenetic location: 13q12.11 Genomic coordinates (GRCh38): 13:19,863,840-20,089,115 (from NCBI)

This gene has 11 transcripts (splice variants), 205 orthologues, 18 paralogues and is associated with 78 phenotypes. Ubiquitous expression in testis (RPKM 14.1), thyroid (RPKM 6.8) and 25 other tissues.

Summary

The protein encoded by this gene is a Zinc Finger Protein that may act as a transcription factor. The encoded protein may be part of a BHC histone deacetylase complex. Translocation of this gene with the Fibroblast Growth Factor receptor-1 gene (FGFR1) results in a fusion gene, which may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]

ZMYM2 Products (11)

mRNA Protein Name
NM_001190964.4 NP_001177893.1 zinc finger MYM-type protein 2 isoform 1
NM_001190965.4 NP_001177894.1 zinc finger MYM-type protein 2 isoform 1
NM_001353157.2 NP_001340086.1 zinc finger MYM-type protein 2 isoform 1
NM_001353159.2 NP_001340088.1 zinc finger MYM-type protein 2 isoform 1
NM_001353161.3 NP_001340090.1 zinc finger MYM-type protein 2 isoform 2 precursor
NM_001353162.3 NP_001340091.1 zinc finger MYM-type protein 2 isoform 1
NM_001353163.2 NP_001340092.1 zinc finger MYM-type protein 2 isoform 3
NM_001353164.2 NP_001340093.1 zinc finger MYM-type protein 2 isoform 1
NM_001353165.2 NP_001340094.1 zinc finger MYM-type protein 2 isoform 4
NM_003453.6 NP_003444.1 zinc finger MYM-type protein 2 isoform 1
NM_197968.4 NP_932072.1 zinc finger MYM-type protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
26275350 GOA
enables ubiquitin conjugating enzyme binding IPI
IPI: Inferred from physical interaction
12776193 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
32891193 GOA
Cellular Component GO Annotation Evidence References Source
located in PML body IDA
IDA: Inferred from direct assay
17027752 GOA
located in nucleus IDA
IDA: Inferred from direct assay
32891193 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZMYM2 Protein Structure

zf-FCS

zf-FCS: MYM-type Zinc finger with FCS sequence motif (325 - 363)

zf-FCS

zf-FCS: MYM-type Zinc finger with FCS sequence motif (366 - 409)

zf-FCS

zf-FCS: MYM-type Zinc finger with FCS sequence motif (420 - 456)

zf-FCS

zf-FCS: MYM-type Zinc finger with FCS sequence motif (460 - 502)

zf-FCS

zf-FCS: MYM-type Zinc finger with FCS sequence motif (529 - 570)

zf-FCS

zf-FCS: MYM-type Zinc finger with FCS sequence motif (582 - 616)

zf-FCS

zf-FCS: MYM-type Zinc finger with FCS sequence motif (634 - 671)

zf-FCS

zf-FCS: MYM-type Zinc finger with FCS sequence motif (721 - 758)

zf-FCS

zf-FCS: MYM-type Zinc finger with FCS sequence motif (761 - 799)

DUF3504

DUF3504: Domain of unknown function (DUF3504) (1190 - 1360)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1377 a.a.
Protein Preferred Names Protein Names

zinc finger MYM-type protein 2

  • fused in myeloproliferative disorders protein

ZMYM2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZMYM2 Q9UBW7 GTF2IRD1 Homo sapiens Q9UHL9
Y2H
26275350
Intra
ZMYM2 Q9UBW7 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Neurodevelopmental-Craniofacial Syndrome With Variable Renal And Cardiac Abnormalities

  • NECRC
Lymphoblastic Lymphoma

  • Lymphoma, Lymphoblastic

  • Lymphoma Lymphoblastic

  • Precursor Cell Lymphoblastic Lymphoma

  • Precursor Cell Lymphoblastic Leukemia Lymphoma
Cakut

  • Renal Or Urinary Tract Malformation

  • Congenital Anomalies Of Kidney And Urinary Tract

  • Congenital Anomaly Of Kidney And Urinary Tract

  • Congenital Anomalies Of The Kidney And Urinary Tract

  • Kidney And Urinary Tract, Anomalies, Congenital

  • Renal Hypodysplasia, Nonsyndromic, 1
Lymphoma

  • Lymphoid Cancer

  • Lymphomas

  • Lymphoid Cancers

  • Lymphoid Neoplasm

  • Lymphoma Nos

  • Nhl - [Non-Hodgkin Lymphoma]

  • Non-Hodgkin Lymphoma

  • Non-Hodgkin Lymphoma, Nos

  • Non-Hodgkin Malignant Lymphoma Nos
Myeloid And Lymphoid Neoplasms Associated With Fgfr1 Abnormalities
Myeloproliferative Neoplasm

  • Myeloproliferative Disorder

  • Chronic Myeloproliferative Disease

  • Myeloproliferative Neoplasms

  • Chronic Myeloproliferative Disorder

  • Cmpd

  • Cmpd, U

  • Chronic Myeloproliferative Disorders

  • Mpd

  • Mpn

  • Myeloproliferative Disorders

  • Myeloproliferative Disease

  • Campomelic Dysplasia
Leukemia

  • Leukemias

  • Leukaemia, Unspecified, Without Mention Of Remission

  • Aleukemic Leukaemia

  • Chronic Leukaemia

  • Subacute Leukaemia

  • Leukaemia Disorder

  • Leukaemia Nos
Myeloid And Lymphoid Neoplasms With Eosinophilia And Abnormalities Of Pdgfra, Pdgfrb, And Fgfr1

  • Myeloid And Lymphoid Neoplasms With Eosinophilia And Abnormalities Of Platelet-Derived Growth Factor Receptor Alpha , Platelet-Derived Growth Factor Receptor Beta , And Fibroblast Growth Factor Receptor-1 Are A Group Of Hematologic Neoplasms

  • Myeloid And Lymphoid Neoplasms With Eosinophilia And Rearrangement Of Pdgfra, Pdgfrb, Or Fgfr1, Or With Pcm1-Jak2
Chronic Eosinophilic Leukemia

  • Pdgfra-Associated Chronic Eosinophilic Leukemia
Lymphoma, Non-Hodgkin, Familial

  • Non-Hodgkin Lymphoma

  • Lymphoma, Non-Hodgkin

  • NHL

  • Lymphoma, Non-Hodgkin, Somatic

  • Lymphoma, Follicular, Somatic

  • Familial Non-Hodgkin Lymphoma

  • Lymphoma Non-Hodgkins

  • Follicular Lymphoma, Somatic

  • Lymphosarcoma

  • Non-Hodgkins Lymphoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16089 ZMYM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21810 Zmym2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28326 Zmym2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ZMYM2 RGD RGD:1593255
Macaca mulatta ZMYM2 VGNC VGNC:78865
Felis catus ZMYM2 VGNC VGNC:67258
Mus musculus ZMYM2 MGD MGI:1923257
Canis familiaris ZMYM2 VGNC VGNC:48646
Bos taurus ZMYM2 VGNC VGNC:56646
Others ZMYM2 NCBI