EMC2 - ER membrane protein complex subunit 2 Gene

Also Known as TTC35; KIAA0103

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9694

About EMC2

Cytogenetic location: 8q23.1 Genomic coordinates (GRCh38): 8:108,443,624-108,489,196 (from NCBI)

This gene has 7 transcripts (splice variants) and 222 orthologues. Ubiquitous expression in testis (RPKM 34.1), fat (RPKM 27.5) and 25 other tissues.

Summary

Contributes to membrane insertase activity. Involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Located in endoplasmic reticulum membrane. Is extrinsic component of endoplasmic reticulum membrane. Part of EMC complex. [provided by Alliance of Genome Resources, Apr 2022]

EMC2 Products (4)

mRNA Protein Name
NM_001329493.2 NP_001316422.1 ER membrane protein complex subunit 2 isoform 1
NM_001329494.2 NP_001316423.1 ER membrane protein complex subunit 2 isoform 3
NM_001329495.2 NP_001316424.1 ER membrane protein complex subunit 2 isoform 4
NM_014673.5 NP_055488.1 ER membrane protein complex subunit 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to membrane insertase activity IMP
IMP: Inferred from mutant phenotype
29809151 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence IDA
IDA: Inferred from direct assay
29242231 GOA
involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence IMP
IMP: Inferred from mutant phenotype
29809151 GOA
involved in tail-anchored membrane protein insertion into ER membrane IDA
IDA: Inferred from direct assay
29242231 GOA
Cellular Component GO Annotation Evidence References Source
part of EMC complex IDA
IDA: Inferred from direct assay
22119785 GOA
part of EMC complex IPI
IPI: Inferred from physical interaction
32439656 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
22119785 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
10942595 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
22119785 GOA
located in extrinsic component of endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
32439656 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EMC2 Protein Structure

TPR_1

TPR_1: Tetratricopeptide repeat (98 - 120)

TPR_19

TPR_19: Tetratricopeptide repeat (133 - 191)

  • 0
  • 100
  • 200
  • 297 a.a.
Protein Preferred Names Protein Names

ER membrane protein complex subunit 2

  • TPR repeat protein 35

EMC2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EMC2 Q15006 COX4NB Homo sapiens Q53Y03
Validated Y2H
25416956
Intra
EMC2 Q15006 COX4NB Homo sapiens Q53Y03
Y2H Array
25416956
Intra
EMC2 Q15006 EMC3 Homo sapiens Q9P0I2
Anti Tag CoIP
35271311
Intra
EMC2 Q15006 EMC3 Homo sapiens Q9P0I2
Anti Tag CoIP
26496610
Intra
EMC2 Q15006 EMC3 Homo sapiens Q9P0I2
Anti Tag CoIP
33961781
Intra
EMC2 Q15006 EMC3 Homo sapiens Q9P0I2
Anti Tag CoIP
32439656
Intra
EMC2 Q15006 EMC3 Homo sapiens Q9P0I2
Pull Down
22119785
Intra
EMC2 Q15006 SS18L2 Homo sapiens Q9UHA2
Validated Y2H
32296183
Intra
EMC2 Q15006 PCDHB12 Homo sapiens Q9Y5F1
Validated Y2H
32296183
Intra
EMC2 Q15006 HSP90B1 Homo sapiens Q96GW1
Validated Y2H
32296183
Intra
EMC2 Q15006 MMGT1 Homo sapiens Q8N4V1
Anti Tag CoIP
28514442
Intra
EMC2 Q15006 MMGT1 Homo sapiens Q8N4V1
Anti Tag CoIP
26496610
Intra
EMC2 Q15006 MMGT1 Homo sapiens Q8N4V1
Anti Tag CoIP
33961781
Intra
EMC2 Q15006 MMGT1 Homo sapiens Q8N4V1
Anti Tag CoIP
35271311
Intra
EMC2 Q15006 MMGT1 Homo sapiens Q8N4V1
Pull Down
22119785
Intra
EMC2 Q15006 MMGT1 Homo sapiens Q8N4V1
Anti Tag CoIP
32439656
Intra
EMC2 Q15006 EMC8 Homo sapiens O43402
Y2H Pooling
16189514
Intra
EMC2 Q15006 EMC8 Homo sapiens O43402
Anti Tag CoIP
28514442
Intra
EMC2 Q15006 EMC8 Homo sapiens O43402
Pull Down
22119785
Intra
EMC2 Q15006 EMC8 Homo sapiens O43402
Anti Tag CoIP
35271311
Intra
EMC2 Q15006 EMC8 Homo sapiens O43402
Y2H Prey Pooling
32296183
Intra
EMC2 Q15006 EMC8 Homo sapiens O43402
Anti Tag CoIP
26496610
Intra
EMC2 Q15006 EMC8 Homo sapiens O43402
Anti Tag CoIP
32439656
Intra
EMC2 Q15006 EMC8 Homo sapiens O43402
Crosslink
30021884
Intra
EMC2 Q15006 EMC8 Homo sapiens O43402
Y2H Array
32296183
Intra
EMC2 Q15006 EMC8 Homo sapiens O43402
Anti Tag CoIP
33961781
Intra
EMC2 Q15006 IKZF3 Homo sapiens Q9UKT9
Y2H Prey Pooling
25416956
Intra
EMC2 Q15006 SH3BP5L Homo sapiens Q7L8J4
Y2H Prey Pooling
32296183
Intra
EMC2 Q15006 SH3BP5L Homo sapiens Q7L8J4
Validated Y2H
32296183
Intra
EMC2 Q15006 SH3BP5L Homo sapiens Q7L8J4
Y2H Array
32296183
Intra
EMC2 Q15006 EMC9 Homo sapiens Q9Y3B6
Anti Tag CoIP
32439656
Intra
EMC2 Q15006 EMC9 Homo sapiens Q9Y3B6
Y2H Prey Pooling
32296183
Intra
EMC2 Q15006 EMC9 Homo sapiens Q9Y3B6
Anti Tag CoIP
35271311
Intra
EMC2 Q15006 EMC9 Homo sapiens Q9Y3B6
Validated Y2H
25416956
Intra
EMC2 Q15006 EMC9 Homo sapiens Q9Y3B6
Y2H Pooling
16189514
Intra
EMC2 Q15006 EMC9 Homo sapiens Q9Y3B6
Validated Y2H
32296183
Intra
EMC2 Q15006 EMC9 Homo sapiens Q9Y3B6
Pull Down
22119785
Intra
EMC2 Q15006 EMC9 Homo sapiens Q9Y3B6
Anti Tag CoIP
33961781
Intra
EMC2 Q15006 EMC9 Homo sapiens Q9Y3B6
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Fanconi Anemia, Complementation Group D2

  • Fanconi Anemia Complementation Group D2

  • FANCD2

  • Fad2

  • Fa4

  • Fancd

  • Fanconi Pancytopenia Type 4

  • Fanconi Anemia, Complementation Group D

  • Fanconi Pancytopenia, Type 4

  • Facd

  • Fanconi Anemia Complementation Group D
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04337 EMC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus EMC2 RGD RGD:1310430
Felis catus EMC2 VGNC VGNC:61833
Bos taurus EMC2 VGNC VGNC:28463
Mus musculus EMC2 MGD MGI:1913986
Macaca mulatta EMC2 VGNC VGNC:72135
Others EMC2 NCBI