EMC3 - ER membrane protein complex subunit 3 Gene

Also Known as POB; TMEM111

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55831

About EMC3

This gene has 8 transcripts (splice variants) and 211 orthologues. Ubiquitous expression in fat (RPKM 29.9), testis (RPKM 23.1) and 25 other tissues.

Summary

Contributes to membrane insertase activity. Involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Is integral component of endoplasmic reticulum membrane. Part of EMC complex. [provided by Alliance of Genome Resources, Apr 2022]

EMC3 Products (2)

mRNA Protein Name
NM_001394674.1 NP_001381603.1 ER membrane protein complex subunit 3
NM_018447.4 NP_060917.1 ER membrane protein complex subunit 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to membrane insertase activity IMP
IMP: Inferred from mutant phenotype
29809151 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22119785 GOA
Biological Process GO Annotation Evidence References Source
involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence IDA
IDA: Inferred from direct assay
29242231 GOA
involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence IMP
IMP: Inferred from mutant phenotype
29809151 GOA
involved in tail-anchored membrane protein insertion into ER membrane IDA
IDA: Inferred from direct assay
29242231 GOA
Cellular Component GO Annotation Evidence References Source
part of EMC complex IDA
IDA: Inferred from direct assay
22119785 GOA
part of EMC complex IPI
IPI: Inferred from physical interaction
32439656 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
32439656 GOA
located in membrane IDA
IDA: Inferred from direct assay
22119785 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EMC3 Protein Structure

DUF106

DUF106: Integral membrane protein DUF106 (5 - 191)

  • 0
  • 100
  • 200
  • 261 a.a.
Protein Preferred Names Protein Names

ER membrane protein complex subunit 3

  • 30 kDa protein

EMC3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EMC3 Q9P0I2 MTAP Homo sapiens Q13126
Y2H Prey Pooling
32296183
Intra
EMC3 Q9P0I2 MTAP Homo sapiens Q13126
Y2H Array
32296183
Intra
EMC3 Q9P0I2 EMC2 Homo sapiens Q15006
Anti Tag CoIP
32439656
Intra
EMC3 Q9P0I2 EMC2 Homo sapiens Q15006
Pull Down
22119785
Intra
EMC3 Q9P0I2 EMC2 Homo sapiens Q15006
Anti Tag CoIP
33961781
Intra
EMC3 Q9P0I2 EMC2 Homo sapiens Q15006
Anti Tag CoIP
35271311
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04338 EMC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus EMC3 VGNC VGNC:61834
Mus musculus EMC3 MGD MGI:1913337
Bos taurus EMC3 VGNC VGNC:28464
Canis familiaris EMC3 VGNC VGNC:40333
Macaca mulatta EMC3 VGNC VGNC:72091
Rattus norvegicus EMC3 RGD RGD:1311566
Others EMC3 NCBI