MTAP - methylthioadenosine phosphorylase Gene

Homo sapiens

Also known as BDMF; MSAP; DMSFH; LGMBF; DMSMFH; c86fus; HEL-249

Gene ID: 4507 | Gene type: protein coding

About MTAP

Cytogenetic location: 9p21.3 Genomic coordinates (GRCh38): 9:21,802,636-21,941,115 (from NCBI)

This gene has 13 transcripts (splice variants), 236 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 5.5), esophagus (RPKM 5.2) and 25 other tissues.

Summary

This gene encodes an Enzyme that plays a major role in polyamine metabolism and is important for the salvage pathway of both adenine and methionine. The encoded Enzyme is deficient in many cancers. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2021]

MTAP Products(7)

mRNA	Protein	Name
NM_001396040.1	NP_001382969.1	S-methyl-5'-thioadenosine phosphorylase isoform 2
NM_001396041.1	NP_001382970.1	S-methyl-5'-thioadenosine phosphorylase isoform 3
NM_001396042.1	NP_001382971.1	S-methyl-5'-thioadenosine phosphorylase isoform 4
NM_001396043.1	NP_001382972.1	S-methyl-5'-thioadenosine phosphorylase isoform 5
NM_001396044.1	NP_001382973.1	S-methyl-5'-thioadenosine phosphorylase isoform 6
NM_001396045.1	NP_001382974.1	S-methyl-5'-thioadenosine phosphorylase isoform 7
NM_002451.4	NP_002442.2	S-methyl-5'-thioadenosine phosphorylase isoform 1

MTAP Protein Structure

PNP_UDP_1

0
100
200
283 a.a.

Protein Preferred Names

Protein Names

S-methyl-5'-thioadenosine phosphorylase

5'-methylthioadenosine phosphorylase

Related Diseases

Diseases

Alias

Diaphyseal Medullary Stenosis With Malignant Fibrous Histiocytoma

DMSMFH	Bone Dysplasia With Medullary Fibrosarcoma
Bdmf	Bone Dysplasia With Malignant Fibrous Histiocytoma
Hardcastle Syndrome	Diaphyseal Medullary Stenosis-Bone Malignancy Syndrome
Myopathy, Limb-Girdle, With Bone Fragility	Bone Dysplasia-Medullary Fibrosarcoma Syndrome
Diaphyseal Medullary Stenosis-Malignant Fibrous Histiocytoma Syndrome	Dms-Mfh
Limb-Girdle Myopathy With Bone Fragility	Stenosis, Medullary, Diaphyseal, With Malignant Fibrous Histiocytoma

Bone Sarcoma

Malignant Fibrous Histiocytoma

Undifferentiated Pleomorphic Sarcoma	Ups
Histiocytoma, Malignant Fibrous	Fibroxanthosarcoma
Mfh	Malignant Fibrohistiocytic Tumors
Histiocytoma, Fibrous, Malignant

Fibrous Histiocytoma

Benign Fibrous Histiocytoma	Histiocytoma, Benign Fibrous
Fibroxanthoma	Histiocytoma Fibrous

Chondrosarcoma

Cartilaginous Cancer	Chondrosarcoma Of Bone
Primary Chondrosarcoma Of The Bone	CHDSA

Benign Mesothelioma

Mesothelioma	Benign Tumor Of Mesothelium
Adenomatoid Tumor

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Sarcomatoid Mesothelioma

Malignant Fibrous Mesothelioma

Spindled Mesothelioma

Biliary Tract Cancer

Malignant Tumour Of Biliary Tract	Biliary Tract Neoplasms
Biliary Tract Neoplasm

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Peritoneal Mesothelioma

Malignant Mesothelioma Of Peritoneum	Advanced Malignant Mesothelioma Of Peritoneum
Advanced Malignant Peritoneal Mesothelioma	Advanced Peritoneal Malignant Mesothelioma

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia	ALL
Acute Lymphocytic Leukemia	Leukemia, Acute Lymphocytic, Susceptibility To, 1
Acute Lymphoblastic Leukaemia	Precursor Lymphoblastic Lymphoma/Leukemia
Precursor Lymphoid Neoplasm	Leukemia, Acute Lymphoblastic, Susceptibility To
B-Cell Acute Lymphoblastic Leukemia	Leukemia, Acute Lymphocytic 1
Acute Lymphocytic Leukaemia	Acute Lymphoblastic Leukemia/Lymphoma
All1	Childhood Acute Lymphoblastic Leukemia
Leukemia Acute Lymphoblastic 1	Leukemia Acute Lymphoblastic B-Hyperdiploid
Leukemia Acute Lymphocytic	Leukemia Acute Lymphocytic 1
Leukemia B-Cell Acute Lymphoblastic	Leukemia T-Cell Acute Lymphoblastic
Leukemia, Acute Lymphoblastic, 3	ALL3
Lymphoblastic Leukemia Acute	Leukemia, Acute, Lymphoblastic
Precursor Cell Lymphoblastic Leukemia Lymphoma	Leukemia, Lymphocytic, Acute, L1
Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Precursor T-Cell Acute Lymphoblastic Leukemia

T-All	Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma
Precursor T-Cell Acute Lymphocytic Leukemia	Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Adult T-Cell Lymphoma/Leukemia

Melanoma, Cutaneous Malignant 1

Familial Melanoma	Melanoma, Cutaneous Malignant, Susceptibility To, 1
Melanoma, Malignant	CMM1
Melanoma, Cutaneous Malignant	Cmm
Familial Atypical Mole-Malignant Melanoma Syndrome	Fammm
Melanoma, Familial	Mlm
Dysplastic Nevus Syndrome, Hereditary	Dns
B-K Mole Syndrome	Melanoma, Cutaneous Malignant, 1
Malignant Melanoma, Cutaneous	Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1
Dysplastic Nevus Syndrome	Cutaneous Melanoma
Familial Atypical Mole Melanoma Syndrome	Hereditary Melanoma

Peritoneum Cancer

Peritoneal Neoplasm	Cancer Of Peritoneum
Malignant Tumor Of Peritoneum	Peritoneal Neoplasms

Pleural Cancer

Pleural Neoplasms	Neoplasm Of Pleura
Pleural Tumor	Malignant Tumor Of Pleura
Pleural Cavity Cancer	Primary Malignant Neoplasm Of Parietal Pleura
Primary Malignant Neoplasm Of Pleura	Primary Malignant Neoplasm Of Visceral Pleura

Myopathy

Muscular Diseases

Myopathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-148419	TNG908	Inhibitor	98.89%	Phase 2
HY-16933	L-Alanosine		≥99.0%	Phase 2

Pre-clinical Phase

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101496	MT-DADMe-ImmA	Inhibitor	98.42%	Unkown
HY-112130	AGI-24512	Inhibitor	99.59%	Unkown
HY-138684	MRTX9768	Inhibitor	99.60%	Unkown
HY-156680	TNG-462	Inhibitor	99.91%	Unkown
HY-138684A	MRTX9768 hydrochloride	Inhibitor	99.68%	Unkown
HY-139611C	MRTX-1719 hydrochloride	Inhibitor	99.22%	Unkown
HY-112129	AGI-25696		/	Unkown
HY-142928	MAT2A-IN-1	Inhibitor	/	Unkown
HY-142929	MAT2A-IN-2	Inhibitor	/	Unkown
HY-142930	MAT2A-IN-3	Inhibitor	/	Unkown
HY-144181	MAT2A-IN-5	Inhibitor	/	Unkown
HY-144184	MAT2A-IN-6	Inhibitor	/	Unkown
HY-144185	MAT2A-IN-7	Inhibitor	/	Unkown
HY-155149	MAT2A-IN-12	Inhibitor	/	Unkown
HY-162010	MAT2A-IN-13	Inhibitor	/	Unkown
HY-162353	AZ'9567	Inhibitor	/	Unkown
HY-RS08749	MTAP Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MTAP	RGD	RGD:1310114
Felis catus	MTAP	VGNC	VGNC:102952
Macaca mulatta	MTAP	VGNC	VGNC:103835
Canis familiaris	MTAP	VGNC	VGNC:56069
Mus musculus	MTAP	MGD	MGI:1914152
Others	MTAP	NCBI

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