MTAP - methylthioadenosine phosphorylase Gene

Also Known as BDMF; MSAP; DMSFH; LGMBF; DMSMFH; c86fus; HEL-249

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4507

About MTAP

Cytogenetic location: 9p21.3 Genomic coordinates (GRCh38): 9:21,802,636-21,941,115 (from NCBI)

This gene has 13 transcripts (splice variants), 236 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 5.5), esophagus (RPKM 5.2) and 25 other tissues.

Summary

This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage pathway of both adenine and methionine. The encoded enzyme is deficient in many cancers. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2021]

MTAP Products (7)

mRNA Protein Name
NM_001396040.1 NP_001382969.1 S-methyl-5'-thioadenosine phosphorylase isoform 2
NM_001396041.1 NP_001382970.1 S-methyl-5'-thioadenosine phosphorylase isoform 3
NM_001396042.1 NP_001382971.1 S-methyl-5'-thioadenosine phosphorylase isoform 4
NM_001396043.1 NP_001382972.1 S-methyl-5'-thioadenosine phosphorylase isoform 5
NM_001396044.1 NP_001382973.1 S-methyl-5'-thioadenosine phosphorylase isoform 6
NM_001396045.1 NP_001382974.1 S-methyl-5'-thioadenosine phosphorylase isoform 7
NM_002451.4 NP_002442.2 S-methyl-5'-thioadenosine phosphorylase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
NOT involved in nicotinamide riboside catabolic process IDA
IDA: Inferred from direct assay
19001417 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MTAP Protein Structure

PNP_UDP_1

PNP_UDP_1: Phosphorylase superfamily (11 - 255)

  • 0
  • 100
  • 200
  • 283 a.a.
Protein Preferred Names Protein Names

S-methyl-5'-thioadenosine phosphorylase

  • 5'-methylthioadenosine phosphorylase

MTAP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MTAP Q13126 CENPH Homo sapiens Q9H3R5
Y2H Array
25416956
Intra
MTAP Q13126 CENPH Homo sapiens Q9H3R5
Validated Y2H
25416956
Intra
MTAP Q13126 EMC3 Homo sapiens Q9P0I2
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

MTAP Antibodies

Cat. No. Product Name Application Reactivity
HY-P83340 MTAP Antibody (YA3085) WB Human, Mouse
HY-P83340A MTAP Antibody (YA3085)(PBS only) WB Human, Mouse

Related Diseases

Diseases Alias
Diaphyseal Medullary Stenosis With Malignant Fibrous Histiocytoma

  • DMSMFH

  • Bone Dysplasia With Medullary Fibrosarcoma

  • Bdmf

  • Bone Dysplasia With Malignant Fibrous Histiocytoma

  • Hardcastle Syndrome

  • Diaphyseal Medullary Stenosis-Bone Malignancy Syndrome

  • Myopathy, Limb-Girdle, With Bone Fragility

  • Bone Dysplasia-Medullary Fibrosarcoma Syndrome

  • Diaphyseal Medullary Stenosis-Malignant Fibrous Histiocytoma Syndrome

  • Dms-Mfh

  • Limb-Girdle Myopathy With Bone Fragility

  • Stenosis, Medullary, Diaphyseal, With Malignant Fibrous Histiocytoma
Bone Sarcoma
Malignant Fibrous Histiocytoma

  • Undifferentiated Pleomorphic Sarcoma

  • Ups

  • Histiocytoma, Malignant Fibrous

  • Fibroxanthosarcoma

  • Mfh

  • Malignant Fibrohistiocytic Tumors

  • Histiocytoma, Fibrous, Malignant
Fibrous Histiocytoma

  • Benign Fibrous Histiocytoma

  • Histiocytoma, Benign Fibrous

  • Fibroxanthoma

  • Histiocytoma Fibrous
Chondrosarcoma

  • Cartilaginous Cancer

  • Chondrosarcoma Of Bone

  • Primary Chondrosarcoma Of The Bone

  • CHDSA
Benign Mesothelioma

  • Mesothelioma

  • Benign Tumor Of Mesothelium

  • Adenomatoid Tumor
Sarcoma

  • Connective And Soft Tissue Neoplasm

  • Tumor Of Soft Tissue And Skeleton

  • Sarcomas

  • Sarcoma - Category
Sarcomatoid Mesothelioma

  • Malignant Fibrous Mesothelioma

  • Spindled Mesothelioma
Biliary Tract Cancer

  • Malignant Tumour Of Biliary Tract

  • Biliary Tract Neoplasms

  • Biliary Tract Neoplasm
Melanoma

  • Malignant Melanoma

  • Cutaneous Melanoma

  • Naevocarcinoma

  • Malignant Melanomas
Peritoneal Mesothelioma

  • Malignant Mesothelioma Of Peritoneum

  • Advanced Malignant Mesothelioma Of Peritoneum

  • Advanced Malignant Peritoneal Mesothelioma

  • Advanced Peritoneal Malignant Mesothelioma
Pancreatic Cancer

  • Pancreatic Carcinoma

  • Carcinoma Of Pancreas

  • Familial Pancreatic Carcinoma

  • Pancreatic Neoplasm

  • Pancreatic Carcinoma, Familial

  • Malignant Neoplasm Of Pancreas

  • Pancreatic Acinar Carcinoma

  • Pancreatic Tumor

  • Familial Pancreatic Cancer

  • Neoplasm Of The Pancreas

  • Cancer Of The Pancreas

  • Pancreatic Carcinoma, Somatic

  • Pancreatic Cancer, Somatic

  • Ca Body Of Pancreas

  • Ca Head Of Pancreas

  • Ca Tail Of Pancreas

  • Malignant Neoplasm Of Body Of Pancreas

  • Malignant Neoplasm Of Head Of Pancreas

  • Malignant Neoplasm Of Tail Of Pancreas

  • Pancreas Neoplasm

  • Exocrine Cancer

  • Exocrine Pancreas Carcinoma

  • Hereditary Pancreatic Cancer

  • Hereditary Pancreatic Carcinoma

  • PNCA

  • Pancreatic Cancer, Susceptibility To

  • Carcinoma Of Head Of Pancreas

  • Pancreatic Neoplasms

  • Pancreatic Tumors

  • Cancer, Pancreatic

  • Cancer Of Pancreas

  • Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Leukemia, Acute Lymphoblastic

  • Acute Lymphoblastic Leukemia

  • ALL

  • Acute Lymphocytic Leukemia

  • Leukemia, Acute Lymphocytic, Susceptibility To, 1

  • Acute Lymphoblastic Leukaemia

  • Precursor Lymphoblastic Lymphoma/Leukemia

  • Precursor Lymphoid Neoplasm

  • Leukemia, Acute Lymphoblastic, Susceptibility To

  • B-Cell Acute Lymphoblastic Leukemia

  • Leukemia, Acute Lymphocytic 1

  • Acute Lymphocytic Leukaemia

  • Acute Lymphoblastic Leukemia/Lymphoma

  • All1

  • Childhood Acute Lymphoblastic Leukemia

  • Leukemia Acute Lymphoblastic 1

  • Leukemia Acute Lymphoblastic B-Hyperdiploid

  • Leukemia Acute Lymphocytic

  • Leukemia Acute Lymphocytic 1

  • Leukemia B-Cell Acute Lymphoblastic

  • Leukemia T-Cell Acute Lymphoblastic

  • Leukemia, Acute Lymphoblastic, 3

  • ALL3

  • Lymphoblastic Leukemia Acute

  • Leukemia, Acute, Lymphoblastic

  • Precursor Cell Lymphoblastic Leukemia Lymphoma

  • Leukemia, Lymphocytic, Acute, L1

  • Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Precursor T-Cell Acute Lymphoblastic Leukemia

  • T-All

  • Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma

  • Precursor T-Cell Acute Lymphocytic Leukemia

  • Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma

  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

  • Adult T-Cell Lymphoma/Leukemia
Melanoma, Cutaneous Malignant 1

  • Familial Melanoma

  • Melanoma, Cutaneous Malignant, Susceptibility To, 1

  • Melanoma, Malignant

  • CMM1

  • Melanoma, Cutaneous Malignant

  • Cmm

  • Familial Atypical Mole-Malignant Melanoma Syndrome

  • Fammm

  • Melanoma, Familial

  • Mlm

  • Dysplastic Nevus Syndrome, Hereditary

  • Dns

  • B-K Mole Syndrome

  • Melanoma, Cutaneous Malignant, 1

  • Malignant Melanoma, Cutaneous

  • Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1

  • Dysplastic Nevus Syndrome

  • Cutaneous Melanoma

  • Familial Atypical Mole Melanoma Syndrome

  • Hereditary Melanoma
Peritoneum Cancer

  • Peritoneal Neoplasm

  • Cancer Of Peritoneum

  • Malignant Tumor Of Peritoneum

  • Peritoneal Neoplasms
Pleural Cancer

  • Pleural Neoplasms

  • Neoplasm Of Pleura

  • Pleural Tumor

  • Malignant Tumor Of Pleura

  • Pleural Cavity Cancer

  • Primary Malignant Neoplasm Of Parietal Pleura

  • Primary Malignant Neoplasm Of Pleura

  • Primary Malignant Neoplasm Of Visceral Pleura
Myopathy

  • Muscular Diseases

  • Myopathies
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-156680 Vopimetostat Inhibitor 99.55% Phase 2
HY-16933 L-Alanosine Inhibitor 99.85% Phase 2

Pre-clinical Phase

Bioactive Molecules (44)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-153390 AMG-193 Inhibitor 99.71% Unkown
HY-148419 Ralometostat Inhibitor 99.90% Unkown
HY-101496 MT-DADMe-ImmA Inhibitor 99.17% Unkown
HY-112130 AGI-24512 Inhibitor 99.46% Unkown
HY-145778 AGI-41998 Inhibitor 98.72% Unkown
HY-162353 AZ'9567 99.19% Unkown
HY-145777 AGI-43192 Inhibitor 99.47% Unkown
HY-138684 MRTX9768 Inhibitor 99.60% Unkown
HY-153390A (R)-AMG-193 Inhibitor 98.53% Unkown
HY-162783 AZ-PRMT5i-1 Inhibitor / Unkown
HY-138684A MRTX9768 hydrochloride Inhibitor 99.88% Unkown
HY-158143 AZD3470 99.74% Unkown
HY-112129 AGI25696-analog / Unkown
HY-142928 MAT2A-IN-1 Inhibitor / Unkown
HY-142929 MAT2A-IN-2 Inhibitor / Unkown
HY-142930 MAT2A-IN-3 Inhibitor / Unkown
HY-144181 MAT2A-IN-5 Inhibitor / Unkown
HY-144184 MAT2A-IN-6 Inhibitor / Unkown
HY-144185 MAT2A-IN-7 Inhibitor / Unkown
HY-155149 MAT2A-IN-12 Inhibitor / Unkown
HY-162010 MAT2A-IN-13 Inhibitor / Unkown
HY-163799 PRMT5-MTA-IN-1 Inhibitor / Unkown
HY-168445 MAT2A-IN-21 Inhibitor / Unkown
HY-170421 MAT2A-IN-16 Inhibitor / Unkown
HY-170905S MAT2A-IN-22 Inhibitor / Unkown
HY-170906S MAT2A-IN-23 Inhibitor / Unkown
HY-172733 PRMT5-MTA-IN-3 Inhibitor / Unkown
HY-172733S PRMT5-MTA-IN-3-d3 Inhibitor / Unkown
HY-173281 MAT2A-IN-24 Inhibitor / Unkown
HY-174983 PRMT5-MTA-IN-6 Inhibitor / Unkown
HY-176702 PRMT5-MTA-IN-5 Inhibitor / Unkown
HY-179622 ZS34 / Unkown
HY-180816 PRMT5-MTA-IN-7 Inhibitor / Unkown
HY-180918 ERG-IN-4 / Unkown
HY-180919 ERG-IN-5 Inhibitor / Unkown
HY-181260 PRMT5-MTA-IN-8 / Unkown
HY-182400 AGI-25696 Inhibitor / Unkown
HY-183568 MAT2A-IN-26 Inhibitor / Unkown
HY-183951 TNG456 Inhibitor / Unkown
HY-184290 PRMT5-IN-56 / Unkown
HY-RS08749 MTAP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W750643 m-APTA Substrate 99.54% Unkown
HY-RS16680 Mtap Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23115 Mtap Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MTAP RGD RGD:1310114
Felis catus MTAP VGNC VGNC:102952
Macaca mulatta MTAP VGNC VGNC:103835
Canis familiaris MTAP VGNC VGNC:56069
Mus musculus MTAP MGD MGI:1914152
Others MTAP NCBI