2. Membrane Transporter/Ion Channel Metabolic Enzyme/Protease
  3. Potassium Channel Drug Metabolite
  4. ERG-IN-5

ERG-IN-5 (Compound M1) is a metabolite of ERG-IN-4 (HY-180918), and it is a hERG potassium channel inhibitor with an IC50 of 1.5 μM. ERG-IN-5 is cytotoxic to MTAPdel HCT116 and its CC50 is 28 nM. ERG-IN-5 can be used for the study of colon cancer.

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ERG-IN-5

ERG-IN-5 Chemical Structure

CAS No. : 3047675-62-4

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ERG-IN-5 Related Antibodies

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Description

ERG-IN-5 (Compound M1) is a metabolite of ERG-IN-4 (HY-180918), and it is a hERG potassium channel inhibitor with an IC50 of 1.5 μM. ERG-IN-5 is cytotoxic to MTAPdel HCT116 and its CC50 is 28 nM. ERG-IN-5 can be used for the study of colon cancer[1].

Molecular Weight

483.45

Formula

C23H20F3N7O2
CAS No.
SMILES

NC1=NC(C=CC(C(N(NC(C2CC2)=O)CC3=NC=C(C(F)(F)F)C=C3)=O)=C4)=C4C5=C1C=NN5C
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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ERG-IN-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ERG-IN-53047675-62-4Potassium ChannelDrug MetaboliteKcsAPRMT5 inhibitorsMetabolic stabilityhERG inhibitionMetabolite identificationDeuterium kinetic isotope effectPharmacokineticsSafety profilingInhibitorinhibitorinhibit

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HY-180919
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