(R)-AMG-193

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(R)-AMG-193 is an isomer of AMG 193 (HY-153390). AMG 193 is an orally active MTA-cooperative PRMT5 inhibitor with antitumor activity. AMG 193, when complexed with MTA, preferentially inhibits the growth of MTAP-deficient tumor cells by inhibiting PRMT5 (IC50=0.107 μM), thereby protecting normal cells with wild-type MTAP.

For research use only. We do not sell to patients.

  • Purity: 98.53%
  • CAS No.: 2790567-83-6
  • Formula: C22H19F3N4O3
  • Molecular Weight:444.41
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Biological Activity
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100 mg

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