2790567-83-6
2790567-83-6
Chemical Structure
(R)-AMG-193
- CAS No.: 2790567-83-6
- Formula:C22H19F3N4O3
- Molecular Weight:444.41
InChIKey: BFEBTMFPRJPBTK-IBGZPJMESA-N
SMILES: O=C(N1[C@H](C2=CC=C(C=C2)C(F)(F)F)COCC1)C3=NC=C4N=C(N)C(COC5)=C5C4=C3
Biological Activity: (R)-AMG-193 is an isomer of AMG 193 (HY-153390). AMG 193 is an orally active MTA-cooperative PRMT5 inhibitor with antitumor activity. AMG 193, when complexed with MTA, preferentially inhibits the growth of MTAP-deficient tumor cells by inhibiting PRMT5 (IC50=0.107 μM), thereby protecting normal cells with wild-type MTAP[1][2].
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(R)-AMG-193 | 98.72% | (R)-AMG-193 is an isomer of AMG 193 (HY-153390). AMG 193 is an orally active MTA-cooperative PRMT5 inhibitor with antitumor activity. AMG 193, when complexed with MTA, preferentially inhibits the growth of MTAP-deficient tumor cells by inhibiting PRMT5 (IC50=0.107 μM), thereby protecting normal cells with wild-type MTAP. | ||||||||||||||||||||
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References
- [1]. Belmontes B, et al. Abstract B177: The discovery and preclinical characterization of AMG 193, a first-in-class MTA-cooperative PRMT5 inhibitor with broad activity against MTAP-null cancers[J]. Molecular Cancer Therapeutics, 2023, 22(12_Supplement): B177-B177. https://aacrjournals.org/mct/article/22/12_Supplement/B177/730568
- [2]. Belmontes B, et al. Abstract B177: The discovery and preclinical characterization of AMG 193, a first-in-class MTA-cooperative PRMT5 inhibitor with broad activity against MTAP-null cancers[J]. Molecular Cancer Therapeutics, 2023, 22(12_Supplement): B177-B177. https://aacrjournals.org/mct/article/22/12_Supplement/B177/730568. [Content Brief]
Keywords
