JADA3
JADA3 is a molecular glue degrader targeting IKZF1 and IKZF3. JADA3 induces proteasome-mediated degradation of the target transcription factors by binding to the E3 ubiquitin ligase Cereblon. JADA3 can be used in research related to acute myeloid leukemia.
For research use only. We do not sell to patients.
- CAS No.: 2573901-15-0
- Formula: C10H10ClN3O2
- Molecular Weight:239.66
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
IKZF1 |
IKZF3 |
In Vitro
JADA3 (0.1-1 μM; 24 h) degrades IKZF1 and IKZF3 proteins in Jurkat cells[1].
JADA3 binds to CRBN in the CRBN fluorescence polarization (FP) displacement assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Jurkat cells
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Concentration:0.1 and 1 μM
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Incubation Time:24 h
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Result:Induced CRBN-dependent ubiquitination and proteasomal degradation of IKZF1/IKZF3.
Chemical Information
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CAS No. 2573901-15-0
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Molecular Weight 239.66
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Formula C10H10ClN3O2
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SMILES
O=CC=1C=NN2C(=O)C(=C(Cl)NC12)C(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JADA3 Related Classifications
HY-W450772 Related Classifications
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