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KIFAP3 - kinesin associated protein 3 Gene

Also Known as FLA3; KAP3; SMAP; KAP-1; KAP-3; Smg-GDS; dJ190I16.1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 22920

About KIFAP3

Cytogenetic location: 1q24.2 Genomic coordinates (GRCh38): 1:169,921,329-170,085,184 (from NCBI)

This gene has 6 transcripts (splice variants) and 260 orthologues. Broad expression in brain (RPKM 27.3), testis (RPKM 15.2) and 24 other tissues.

Summary

The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the Other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a Kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

KIFAP3 Products (6)

mRNA	Protein	Name
NM_001204514.2	NP_001191443.1	kinesin-associated protein 3 isoform 2
NM_001204516.2	NP_001191445.1	kinesin-associated protein 3 isoform 3
NM_001204517.2	NP_001191446.1	kinesin-associated protein 3 isoform 4
NM_001375830.1	NP_001362759.1	kinesin-associated protein 3 isoform 5
NM_001375831.1	NP_001362760.1	kinesin-associated protein 3 isoform 6
NM_014970.4	NP_055785.2	kinesin-associated protein 3 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables kinesin binding	IPI IPI: Inferred from physical interaction	16298999	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9506951	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	24338362	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in centrosome	IDA IDA: Inferred from direct assay	16298999	GOA
located in condensed nuclear chromosome	IDA IDA: Inferred from direct assay	16298999	GOA
part of kinesin II complex	IDA IDA: Inferred from direct assay	16298999	GOA
located in microtubule cytoskeleton	IDA IDA: Inferred from direct assay	16298999	GOA
colocalizes with spindle microtubule	IDA IDA: Inferred from direct assay	16298999	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KIFAP3 Protein Structure

KAP

0
200
400
600
792 a.a.

Protein Preferred Names	Protein Names
kinesin-associated protein 3	small G protein GDP dissociation stimulator

KIFAP3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KIFAP3	Q92845	KIF3A	Homo sapiens	Q9Y496	Anti Bait CoIP	16298999
Intra	KIFAP3	Q92845	KIF3A	Homo sapiens	Q9Y496	Anti Tag CoIP	33961781
Intra	KIFAP3	Q92845	KIF3A	Homo sapiens	Q9Y496	TAP	27173435
Intra	KIFAP3	Q92845	KIF3A	Homo sapiens	Q9Y496	Anti Tag CoIP	26496610
Intra	KIFAP3	Q92845	KIF3A	Homo sapiens	Q9Y496	Anti Tag CoIP	28514442
Intra	KIFAP3	Q92845	C19orf44	Homo sapiens	Q9H6X5-2	Validated Y2H	32296183
Intra	KIFAP3	Q92845	NAA11	Homo sapiens	Q9BSU3	Validated Y2H	32296183
Intra	KIFAP3	Q92845	KIF3B	Homo sapiens	O15066	Anti Tag CoIP	33961781
Intra	KIFAP3	Q92845	KIF3B	Homo sapiens	O15066	Anti Bait CoIP	16298999
Intra	KIFAP3	Q92845	KIF3B	Homo sapiens	O15066	TAP	27173435
Intra	KIFAP3	Q92845	KIF3B	Homo sapiens	O15066	Anti Tag CoIP	28514442
Intra	KIFAP3	Q92845	KIF3B	Homo sapiens	O15066	Anti Tag CoIP	26496610
Intra	KIFAP3	Q92845	NCF2	Homo sapiens	P19878	Y2H Array	31515488
Intra	KIFAP3	Q92845	NAA10	Homo sapiens	P41227	Validated Y2H	25416956
Intra	KIFAP3	Q92845	NAA10	Homo sapiens	P41227	Y2H Array	25416956
Intra	KIFAP3	Q92845	NAA10	Homo sapiens	P41227	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

KIFAP3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83024	KIFAP3 Antibody (YA2769)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Breast Lipoma	Lipoma Of Breast
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Bardet-Biedl Syndrome	Bbs Biedl-Bardet Syndrome
Asphyxiating Thoracic Dystrophy	Jeune Thoracic Dystrophy Jeune Syndrome Asphyxiating Thoracic Dysplasia Short-Rib Thoracic Dysplasia With Or Without Polydactyly Thoracic Pelvic Phalangeal Dystrophy Asphyxiating Thoracic Chondrodystrophy Atd Chondroectodermal Dysplasia-Like Syndrome Infantile Thoracic Dystrophy Jeune Thoracic Dysplasia Thoracic Asphyxiant Dystrophy Thoracic-Pelvic-Phalangeal Dystrophy Short-Rib Thoracic Dysplasia Without Polydactyly Asphyxiating Thoracic Dystrophy Of The Newborn Asphyxiating Thorax Dystrophy
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07297	KIFAP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KIFAP3	MGD	MGI:107566
Canis familiaris	KIFAP3	VGNC	VGNC:42413
Felis catus	KIFAP3	VGNC	VGNC:63120
Rattus norvegicus	KIFAP3	RGD	RGD:1305191
Macaca mulatta	KIFAP3	VGNC	VGNC:73842
Bos taurus	KIFAP3	VGNC	VGNC:30610
Others	KIFAP3	NCBI