KIF3B - kinesin family member 3B Gene

Also Known as FLA8; RP89; HH0048; KLP-11

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9371

About KIF3B

Cytogenetic location: 20q11.21 Genomic coordinates (GRCh38): 20:32,277,651-32,335,011 (from NCBI)

This gene has 1 transcript (splice variant), 206 orthologues, 41 paralogues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 22.2), kidney (RPKM 21.4) and 25 other tissues.

Summary

The protein encoded by this gene acts as a heterodimer with Kinesin family member 3A to aid in chromosome movement during Mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. This protein and Kinesin family member 3A form the Kinesin II subfamily of the Kinesin superfamily. [provided by RefSeq, Jul 2008]

KIF3B Products (1)

mRNA	Protein	Name
NM_004798.4	NP_004789.1	kinesin-like protein KIF3B

KIF3B Protein Structure

Kinesin

0
200
400
600
747 a.a.

Protein Preferred Names	Protein Names
kinesin-like protein KIF3B	microtubule plus end-directed kinesin motor 3B

KIF3B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KIF3B	O15066	CLCN5	Homo sapiens	P51795	Confocal	19940036
Intra	KIF3B	O15066	ARHGEF10	Homo sapiens	O15013	IF	19635168
Intra	KIF3B	O15066	ARHGEF10	Homo sapiens	O15013	Anti Tag CoIP	19635168
Intra	KIF3B	O15066	KIFAP3	Homo sapiens	Q92845	Anti Bait CoIP	16298999
Intra	KIF3B	O15066	KIFAP3	Homo sapiens	Q92845	TAP	27173435
Intra	KIF3B	O15066	KIFAP3	Homo sapiens	Q92845	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

KIF3B Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89620	KIF3B Antibody (YA8964)	WB, ICC/IF, IF-Tissue, IP, ELISA	human, mouse, rat

Related Diseases

Diseases	Alias
Retinitis Pigmentosa 89	RP89 Retinitis Pigmentosa, Type 89
Myasthenic Syndrome, Congenital, 16	Congenital Myasthenic Syndrome 16 CMS16 Myasthenic Syndrome, Congenital, Acetazolamide-Responsive Congenital Myasthenic Syndrome Acetazolamide-Responsive Congenital Myasthenic Syndrome Due To Mutation In Scn4a Congenital Myasthenic Syndrome Scn4a-Related
Polydactyly	Non-Syndromic Polydactyly Polydactyly, Postaxial Postaxial Polydactyly Supernumerary Digit Extra Digits Hyperdactyly Polydactylia Polydactylism Supernumerary Digits
Kartagener Syndrome	Kartagener'S Syndrome
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Visceral Heterotaxy	Situs Ambiguus Heterotaxia Heterotaxy Syndrome Heterotaxy Lateralization Defect Situs Ambiguous Left Isomerism Htx Ivemark Syndrome Right Isomerism Situs Ambiguus Viscerum Incomplete Situs Inversus Partial Situs Inversus Heterotaxy, Visceral Asplenia Syndrome Bilateral Left-Sidedness Polysplenia Syndrome Moller Syndrome
Asphyxiating Thoracic Dystrophy	Jeune Thoracic Dystrophy Jeune Syndrome Asphyxiating Thoracic Dysplasia Short-Rib Thoracic Dysplasia With Or Without Polydactyly Thoracic Pelvic Phalangeal Dystrophy Asphyxiating Thoracic Chondrodystrophy Atd Chondroectodermal Dysplasia-Like Syndrome Infantile Thoracic Dystrophy Jeune Thoracic Dysplasia Thoracic Asphyxiant Dystrophy Thoracic-Pelvic-Phalangeal Dystrophy Short-Rib Thoracic Dysplasia Without Polydactyly Asphyxiating Thoracic Dystrophy Of The Newborn Asphyxiating Thorax Dystrophy
Situs Inversus	Situs Inversus Viscerum Laterality Sequence Complete Transposition Siv
Cystic Kidney Disease	Renal Cyst Simple Renal Cyst Kidney Cysts Kidney Diseases, Cystic Renal Cysts Kidney Cyst Cystic Kidney Congenital Cystic Kidney Disease Cystic Kidney Diseases Bosniak 1 Cyst
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary
Meckel Syndrome, Type 1	Meckel-Gruber Syndrome Meckel Syndrome Dysencephalia Splanchnocystica Meckel Syndrome 1 MKS1 Mks Gruber Syndrome Meckel-Gruber Syndrome, Type 1 Mes Dysencephalia Splachnocystica Meckel Gruber Syndrome Meckel Syndrome Type 1
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy
Polycystic Kidney Disease	Polycystic Kidney Diseases Pkd Polycystic Renal Disease Kidney Disease, Polycystic Polycystic Kidney, Autosomal Dominant
Joubert Syndrome 1	Joubert Syndrome Jbts Cerebellooculorenal Syndrome 1 JBTS1 Joubert-Boltshauser Syndrome Cerebelloparenchymal Disorder Iv Cpd4 Cors1 Joubert Syndrome And Related Disorders Jsrd Familial Aplasia Of The Vermis Joubert Syndrome Related Disorders Js Cerebellar Vermis Agenesis Cerebelloparenchymal Disorder 4 Agenesis Of Cerebellar Vermis Cerebello-Oculo-Renal Syndrome Cors Joubert-Bolthauser Syndrome Cpd Iv Classic Joubert Syndrome Joubert Syndrome Type A Pure Joubert Syndrome Cerebello-Oculo-Renal Syndrome 1 Joubert Syndrome-1 Joubert Syndrome, Type 1 Joubert'S Syndrome
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-175496	Acid Ceramidase-IN-3	Inhibitor	/	Unkown
HY-182741	RET-IN-32	Inhibitor	/	Unkown
HY-RS07286	KIF3B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22596	Kif3b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29113	Kif3b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KIF3B	MGD	MGI:107688
Bos taurus	KIF3B	VGNC	VGNC:30603
Rattus norvegicus	KIF3B	RGD	RGD:1306815
Canis familiaris	KIF3B	VGNC	VGNC:42405
Felis catus	KIF3B	VGNC	VGNC:67942
Macaca mulatta	KIF3B	VGNC	VGNC:74018
Others	KIF3B	NCBI