PEG10 - paternally expressed 10 Gene

Also Known as EDR; HB-1; Mar2; RTL2; MEF3L; Mart2; RGAG3; SIRH1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23089

About PEG10

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:94,656,325-94,669,695 (from NCBI)

This gene has 9 transcripts (splice variants), 274 orthologues and 10 paralogues. Biased expression in placenta (RPKM 304.5), adrenal (RPKM 114.1) and 3 other tissues.

Summary

This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation and Apoptosis. Overexpression of this gene has been associated with several malignancies, such as hepatocellular carcinoma and B-cell lymphocytic leukemia. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. Additional isoforms resulting from alternatively spliced transcript variants, and use of upstream non-AUG (CUG) start codon have been reported for this gene. [provided by RefSeq, Oct 2014]

PEG10 Products (6)

mRNA Protein Name
NM_001040152.2 NP_001035242.1 retrotransposon-derived protein PEG10 isoform 2
NM_001172437.2 NP_001165908.1 retrotransposon-derived protein PEG10 isoform 3
NM_001172438.3 NP_001165909.1 retrotransposon-derived protein PEG10 isoform 4
NM_001184961.1 NP_001171890.1 retrotransposon-derived protein PEG10 isoform 5
NM_001184962.2 NP_001171891.1 retrotransposon-derived protein PEG10 isoform 6
NM_015068.3 NP_055883.2 retrotransposon-derived protein PEG10 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15611116 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
15611116 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15611116 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PEG10 Protein Structure

Retrotrans_gag

Retrotrans_gag: Retrotransposon gag protein (120 - 211)

  • 0
  • 100
  • 200
  • 300
  • 325 a.a.
Protein Preferred Names Protein Names

retrotransposon-derived protein PEG10

  • MEF3 like 1

PEG10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PEG10 Q86TG7 RTL8C Homo sapiens A6ZKI3
Anti Tag CoIP
33961781
Intra
PEG10 Q86TG7 RTL8C Homo sapiens A6ZKI3
Validated Y2H
25416956
Intra
PEG10 Q86TG7 RTL8B Homo sapiens Q17RB0
Anti Tag CoIP
33961781
Intra
PEG10 Q86TG7 RTL8B Homo sapiens Q17RB0
Y2H Prey Pooling
25416956
Intra
PEG10 Q86TG7 LNX2 Homo sapiens Q8N448
Y2H Array
29892012
Intra
PEG10 Q86TG7 LNX2 Homo sapiens Q8N448
Y2H Array
31515488
Intra
PEG10 Q86TG7 CALCOCO2 Homo sapiens Q13137
Y2H Array
31515488
Intra
PEG10 Q86TG7 CALCOCO2 Homo sapiens Q13137
Y2H Prey Pooling
25416956
Intra
PEG10 Q86TG7 CALCOCO2 Homo sapiens Q13137
Validated Y2H
25416956
Intra
PEG10 Q86TG7 CALCOCO2 Homo sapiens Q13137
Y2H Array
25416956
Intra
PEG10 Q86TG7 LDOC1 Homo sapiens O95751
Y2H Array
31515488
Intra
PEG10 Q86TG7 LDOC1 Homo sapiens O95751
Anti Tag CoIP
33961781
Intra
PEG10 Q86TG7 LDOC1 Homo sapiens O95751
Y2H Prey Pooling
25416956
Intra
PEG10 Q86TG7 SIAH1 Homo sapiens Q8IUQ4
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

PEG10 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81532 PEG10 Antibody (YA1277) IHC-P Human
HY-P81532A PEG10 Antibody (YA1277)(PBS only) IHC-P Human
HY-P85323 PEG10 Antibody (YA5015) WB, IHC-P Human
HY-P85450 PEG10 Antibody (YA5142) WB, ICC/IF, FC Human, Mouse, Rat
HY-P85573 PEG10 Antibody (YA5265) WB, IP Human

Related Diseases

Diseases Alias
Diffuse Large B-Cell Lymphoma

  • Dlbcl

  • Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

  • Large B-Cell Diffuse Lymphoma

  • Lymphoma, Large B-Cell, Diffuse

  • Dlbcl - [Diffuse Large B-Cell Lymphoma]

  • Diffuse Large Beta Cell Lymphoma
Esophageal Cancer

  • Esophageal Carcinoma

  • Carcinoma Of Esophagus

  • Esophageal Squamous Cell Carcinoma, Somatic

  • Esophageal Carcinoma, Somatic

  • Esophagus Cancer

  • Gastric Cardia Adenocarcinoma

  • Esophageal Neoplasms

  • Esophageal Cancer, Somatic

  • Cancer Of Esophagus

  • Cancer Of Oesophagus

  • Carcinoma Of Oesophagus

  • Ca Lower Third Oesophagus

  • Ca Middle Third Oesophagus

  • Malignant Neoplasm Of Distal Third Of Esophagus

  • Malignant Neoplasm Of Lower Third Of Oesophagus

  • Malignant Neoplasm Of Middle Third Of Oesophagus

  • Malignant Neoplasm Of Proximal Third Of Esophagus

  • Malignant Neoplasm Of Upper Third Esophagus

  • Malignant Tumor Of Abdominal Esophagus

  • Malignant Tumor Of Distal Third Of Esophagus

  • Malignant Tumor Of Proximal Third Of Esophagus

  • Malignant Tumor Of The Middle Third Of The Esophagus

  • ESCR

  • Aerodigestive Tract Cancer

  • Escc

  • Esophageal Squamous Cell Carcinoma

  • Cancer, Esophageal

  • Malignant Neoplasm Of Esophagus

  • Squamous Cell Carcinoma Of Esophagus

  • Malignant Neoplasm Of Middle Third Of Esophagus
B-Lymphoblastic Leukemia/Lymphoma

  • B Lymphoblastic Leukemia/Lymphoma

  • B-All

  • Precursor B Lymphoblastic Lymphoma/Leukemia

  • C-All

  • Lymphoblastic Lymphoma, Nos

  • Common Precursor B All

  • Lymphoblastic B-Cell Lymphoma

  • Pro-B All

  • B-Precursor Lymphoma

  • Lbl - [Lymphoblastic Lymphoma]
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Angelman Syndrome

  • AS

  • Happy Puppet Syndrome

  • Happy Puppet Syndrome, Formerly

  • Puppetlike Syndrome
Gallbladder Adenocarcinoma

  • Adenocarcinoma Of The Gallbladder

  • Carcinoma Of The Gallbladder
Silver-Russell Syndrome 1

  • Silver-Russell Syndrome

  • Russell-Silver Syndrome

  • Silver-Russell Dwarfism

  • Rss

  • SRS1

  • Srs

  • Silver Russell Dwarfism

  • Russell Silver Syndrome

  • Silver Russell Syndrome
Leukemia, Chronic Lymphocytic

  • Chronic Lymphocytic Leukemia

  • B-Cell Chronic Lymphocytic Leukemia

  • CLL

  • B-Cell Chronic Lymphoid Leukemia

  • Chronic Lymphatic Leukemia

  • Chronic Lymphocytic Leukaemia

  • Lymphoplasmacytic Leukemia

  • Small Lymphocytic Lymphoma

  • Leukemia, Chronic Lymphatic

  • B-Cell Chronic Lymphocytic Leukaemia

  • Chronic Lymphatic Leukaemia

  • Lymphoplasmacytic Leukaemia

  • B Cell Chronic Lymphocytic Leukemia

  • Chronic B-Cell Lymphocytic Leukemia

  • Leukemia, Lymphocytic, Chronic

  • B-Cll

  • Chronic Lymphoid Leukemia

  • Leukemia Lymphocytic Chronic

  • Lymphoma Small Lymphocytic

  • Leukemia, Lymphocytic, Chronic, B-Cell
Spastic Paraplegia 17, Autosomal Dominant

  • Silver Syndrome

  • SPG17

  • Silver Spastic Paraplegia Syndrome

  • Spastic Paraplegia With Amyotrophy Of Hands And Feet

  • Hereditary Spastic Paraplegia 17

  • Autosomal Dominant Spastic Paraplegia Type 17

  • Spastic Paraplegia 17

  • Spastic Paraplegia-Amyotrophy Of Hands And Feet

  • Autosomal Dominant Spastic Paraplegia 17

  • Dhmn5b

  • Distal Hereditary Motor Neuropathy Type 5b

  • Paraplegia, Spastic, Autosomal Dominant, Type 17

  • Russell-Silver Syndrome

  • Neuronopathy, Distal Hereditary Motor, Type Vb
Transient Neonatal Diabetes Mellitus

  • Diabetes Mellitus, Transient Neonatal

  • Tndm

  • Chromosome 6-Associated Transient Diabetes Mellitus

  • Dmtn

  • Diabetes Mellitus, 6q24-Related Transient Neonatal

  • Tndm1

  • Neonatal Diabetes Mellitus, Transient

  • Tndm -[Transient Neonatal Diabetes Mellitus]
Osteogenesis Imperfecta, Type Iii

  • Osteogenesis Imperfecta Type Iii

  • OI3

  • Oi, Type Iii

  • Osteogenesis Imperfecta Type 3

  • Oi Type Iii

  • Oi Type 3

  • Progressive Deforming Osteogenesis Imperfecta

  • Severe Osteogenesis Imperfecta

  • Osteogenesis Imperfecta, Progressively Deforming, With Normal Sclerae

  • Progressively Deforming Osteogenesis Imperfecta With Normal Sclera

  • Osteogenesis Imperfecta, Progressively Deforming With Normal Sclerae

  • Progressively Deforming Oi

  • Osteogenesis Imperfecta 3

  • Oi-Iii

  • Progressively Deforming Osteogenesis Imperfecta With Normal Sclerae
Beckwith-Wiedemann Syndrome

  • Wiedemann-Beckwith Syndrome

  • BWS

  • Exomphalos-Macroglossia-Gigantism Syndrome

  • Emg Syndrome

  • Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation

  • Emg Abnormality

  • Wbs

  • Exomphalos Macroglossia Gigantism Syndrome

  • Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation

  • Macroglossia Exomphalos Gigantism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (79)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-140217 Azido-PEG10-amine ≥97.0% Unkown
HY-143855 Biotin-PEG10-NHS ester 98.02% Unkown
HY-133231 Bis-PEG10-acid ≥98.0% Unkown
HY-140759 Azido-PEG10-NHS ester 98.03% Unkown
HY-141120 Boc-NH-PEG10-NHS ester 98.0% Unkown
HY-130824 Bis-PEG10-NHS ester 95.0% Unkown
HY-138726 Mal-PEG10-NHS ester 98.0% Unkown
HY-W190857 N-Boc-PEG10-alcohol 98.0% Unkown
HY-139018A TLR7/8 agonist 4 hydroxy-PEG10-acid hydrochloride 98.28% Unkown
HY-140226 m-PEG10-amine 99.97% Unkown
HY-W040270 Amino-PEG10-amine 97.0% Unkown
HY-126508 Mal-amido-PEG5-C2-​NHS ester ≥98.0% Unkown
HY-126509 Mal-amido-PEG10-C2-​NHS ester 98.0% Unkown
HY-140455 Azido-PEG10-acid 99.88% Unkown
HY-141218 m-PEG10-alcohol ≥97.0% Unkown
HY-RS10318 PEG10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W190862 Biotin-PEG10-azide 98.0% Unkown
HY-181228 DBCO-PEG10-Biotin / Unkown
HY-130424 m-PEG10-azide 99.77% Unkown
HY-135930 Boc-NH-PEG10-CH2CH2NH2 ≥98.0% Unkown
HY-140020 Propargyl-PEG10-acid 98.0% Unkown
HY-140304 DBCO-PEG10-DBCO 96.97% Unkown
HY-140500 m-PEG10-acid 98.0% Unkown
HY-140801 Azido-PEG10-alcohol 97.0% Unkown
HY-143827 Biotin-PEG10-amine 99.83% Unkown
HY-W019939 Hydroxy-PEG10-Boc / Unkown
HY-133304 HO-PEG10-CH2COOH 98.0% Unkown
HY-116027A Biotin-PEG10-acid / Unkown
HY-120761 Amino-PEG10-OH / Unkown
HY-132057 Bis-PEG10-t-butyl ester / Unkown
HY-132065 Decaethylene glycol dodecyl ether 99.91% Unkown
HY-132076 Azido-PEG10-azide / Unkown
HY-132081 Benzyl-PEG10-t-butyl ester / Unkown
HY-132098 Bis-propargyl-PEG10 / Unkown
HY-132118 Bromo-PEG10-t-butyl ester / Unkown
HY-133230 Propargyl-PEG10-amine / Unkown
HY-133270 m-PEG10-SH / Unkown
HY-133307 Hydroxy-PEG10-acid 99.59% Unkown
HY-133312 Hydroxy-PEG10-CH2-Boc / Unkown
HY-134718 Glycocholic acid-PEG10-iodoacetamide / Unkown
HY-134747 THP-PEG10-THP / Unkown
HY-138316 THP-PEG10-C2-Boc / Unkown
HY-138341 Benzyl-PEG10-THP / Unkown
HY-138344 MS-PEG10-THP / Unkown
HY-138347 THP-PEG10-Boc / Unkown
HY-138350 Azido-PEG10-CH2CO2-NHS / Unkown
HY-138390 NH2-PEG10-C2-dimethylamino / Unkown
HY-138413 THP-PEG10-OH / Unkown
HY-138416 Azido-PEG10-CH2COOH / Unkown
HY-138460 Propargyl-PEG10-alcohol / Unkown
HY-138713 Benzyl-PEG10-Ots / Unkown
HY-138721 Fmoc-PEG10-NHS ester / Unkown
HY-138722 Mal-PEG10-Boc / Unkown
HY-138723 Mal-PEG10-acid / Unkown
HY-138739 Azido-PEG10-propargyl / Unkown
HY-139018 TLR7/8 agonist 4 hydroxy-PEG10-acid / Unkown
HY-140029 Propargyl-PEG10-Boc / Unkown
HY-140360 m-PEG10-Tos / Unkown
HY-140386 Ms-PEG10-t-butyl ester / Unkown
HY-140781 Azido-PEG10-Boc / Unkown
HY-140861 Trityl-PEG10-azide / Unkown
HY-140973 Mal-amido-PEG10-acid / Unkown
HY-141104 m-PEG10-NHS ester / Unkown
HY-141130 LG-PEG10-click-DBCO-Oleic / Unkown
HY-141399 m-PEG10-T-Butyl ester / Unkown
HY-143828 t-Boc-N-amido-PEG10-Br / Unkown
HY-143836 Acid-PEG10-t-butyl ester / Unkown
HY-144076 t-Boc-amido-PEG10-acid / Unkown
HY-164654 DOTA-PEG10-azide Control / Unkown
HY-174919 Br-PEG10-OH / Unkown
HY-W096081 Benzyl-PEG10-alcohol / Unkown
HY-133335 Amino-PEG10-CH2-Boc / Unkown
HY-RS20078 Peg10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26581 Peg10 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W800709 N-(acid-PEG10)-N-bis(PEG10-azide) / Unkown
HY-W800715 (Acid-PEG10)-Tri-(Azide-PEG10-ethoxymethyl)-methane / Unkown
HY-W800716 Tri(Azide-PEG10-NHCO-ethyloxyethyl)amine / Unkown
HY-W800717 Tetra-(amido-PEG10-azide) / Unkown
HY-W906996 PEG10-Tos / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PEG10 VGNC VGNC:50004
Canis familiaris PEG10 VGNC VGNC:49685
Mus musculus PEG10 MGD MGI:2157785
Felis catus PEG10 VGNC VGNC:102657
Rattus norvegicus PEG10 RGD RGD:1595574
Others PEG10 NCBI