DBCO-PEG10-DBCO
Based on 1 Customer Validation
DBCO-PEG10-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG10-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- Purity: 96.97%
- Formula: C60H74N4O14
- Molecular Weight:1075.25
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
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PEGs |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Oil
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Molecular Weight 1075.25
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Formula C60H74N4O14
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Color Light yellow to yellow
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SMILES
O=C(NCCC(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(NCCC(N4C5=CC=CC=C5C#CC6=CC=CC=C6C4)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (93.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9300 mL | 4.6501 mL | 9.3002 mL | 23.2504 mL |
| 5 mM | 0.1860 mL | 0.9300 mL | 1.8600 mL | 4.6501 mL | |
| 10 mM | 0.0930 mL | 0.4650 mL | 0.9300 mL | 2.3250 mL | |
| 15 mM | 0.0620 mL | 0.3100 mL | 0.6200 mL | 1.5500 mL | |
| 20 mM | 0.0465 mL | 0.2325 mL | 0.4650 mL | 1.1625 mL | |
| 25 mM | 0.0372 mL | 0.1860 mL | 0.3720 mL | 0.9300 mL | |
| 30 mM | 0.0310 mL | 0.1550 mL | 0.3100 mL | 0.7750 mL | |
| 40 mM | 0.0233 mL | 0.1163 mL | 0.2325 mL | 0.5813 mL | |
| 50 mM | 0.0186 mL | 0.0930 mL | 0.1860 mL | 0.4650 mL | |
| 60 mM | 0.0155 mL | 0.0775 mL | 0.1550 mL | 0.3875 mL | |
| 80 mM | 0.0116 mL | 0.0581 mL | 0.1163 mL | 0.2906 mL |
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