2. PROTAC
  3. PROTAC Linkers
  4. DBCO-PEG10-DBCO

DBCO-PEG10-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG10-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

For research use only. We do not sell to patients.

DBCO-PEG10-DBCO

DBCO-PEG10-DBCO Chemical Structure

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DBCO-PEG10-DBCO Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

DBCO-PEG10-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG10-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DBCO-PEG10-DBCO Related Antibodies
Molecular Weight

1075.25

Formula

C60H74N4O14
Appearance

Oil

Color

Light yellow to yellow

SMILES

O=C(NCCC(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(NCCC(N4C5=CC=CC=C5C#CC6=CC=CC=C6C4)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (93.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9300 mL 4.6501 mL 9.3002 mL
5 mM 0.1860 mL 0.9300 mL 1.8600 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9300 mL 4.6501 mL 9.3002 mL 23.2504 mL
5 mM 0.1860 mL 0.9300 mL 1.8600 mL 4.6501 mL
10 mM 0.0930 mL 0.4650 mL 0.9300 mL 2.3250 mL
15 mM 0.0620 mL 0.3100 mL 0.6200 mL 1.5500 mL
20 mM 0.0465 mL 0.2325 mL 0.4650 mL 1.1625 mL
25 mM 0.0372 mL 0.1860 mL 0.3720 mL 0.9300 mL
30 mM 0.0310 mL 0.1550 mL 0.3100 mL 0.7750 mL
40 mM 0.0233 mL 0.1163 mL 0.2325 mL 0.5813 mL
50 mM 0.0186 mL 0.0930 mL 0.1860 mL 0.4650 mL
60 mM 0.0155 mL 0.0775 mL 0.1550 mL 0.3875 mL
80 mM 0.0116 mL 0.0581 mL 0.1163 mL 0.2906 mL
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DBCO-PEG10-DBCO Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DBCO-PEG10-DBCOPROTAC LinkersInhibitorinhibitorinhibit

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DBCO-PEG10-DBCO
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