TLR7/8 agonist 4 hydroxy-PEG10-acid hydrochloride
Based on 1 Customer Validation
TLR7/8 agonist 4 hydroxy-PEG10-acid hydrochloride (compound 9) is a drug-linker conjugates for ADC with potent antitumor activity by using TLR7/8 agonist 4 (HY-139018; a TLR7/8 agonist), linked via the non-cleavable ADC linker hydroxy-PEG10-acid (HY-133307).
For research use only. We do not sell to patients.
- Purity: 98.28%
- CAS No.: 2388520-36-1
- Formula: C41H69ClN6O12
- Molecular Weight:873.47
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Drug-Linker Conjugates for ADC Isoforms
More
Biological Activity
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Traditional Cytotoxic Agents |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2388520-36-1
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Appearance Solid
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Molecular Weight 873.47
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Formula C41H69ClN6O12
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Color Light yellow to yellow
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SMILES
CCCCC(NC1=C2C(C=CC(N(CC3)CCN3CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O)=C2)=N4)=NC1=C4N.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
H2O : 100 mg/mL (114.49 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.1449 mL | 5.7243 mL | 11.4486 mL | 28.6215 mL |
| 5 mM | 0.2290 mL | 1.1449 mL | 2.2897 mL | 5.7243 mL | |
| 10 mM | 0.1145 mL | 0.5724 mL | 1.1449 mL | 2.8621 mL | |
| 15 mM | 0.0763 mL | 0.3816 mL | 0.7632 mL | 1.9081 mL | |
| 20 mM | 0.0572 mL | 0.2862 mL | 0.5724 mL | 1.4311 mL | |
| 25 mM | 0.0458 mL | 0.2290 mL | 0.4579 mL | 1.1449 mL | |
| 30 mM | 0.0382 mL | 0.1908 mL | 0.3816 mL | 0.9540 mL | |
| 40 mM | 0.0286 mL | 0.1431 mL | 0.2862 mL | 0.7155 mL | |
| 50 mM | 0.0229 mL | 0.1145 mL | 0.2290 mL | 0.5724 mL | |
| 60 mM | 0.0191 mL | 0.0954 mL | 0.1908 mL | 0.4770 mL | |
| 80 mM | 0.0143 mL | 0.0716 mL | 0.1431 mL | 0.3578 mL | |
| 100 mM | 0.0114 mL | 0.0572 mL | 0.1145 mL | 0.2862 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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