1. Antibody-drug Conjugate/ADC Related
    PROTAC
  2. ADC Linker
    PROTAC Linker
  3. m-PEG10-amine

m-PEG10-amine 

Cat. No.: HY-140226
Handling Instructions

m-PEG10-amine is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG10-amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

m-PEG10-amine Chemical Structure

m-PEG10-amine Chemical Structure

CAS No. : 1383658-09-0

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Description

m-PEG10-amine is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. m-PEG10-amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target[1]

PEGs

 

Non-cleavable

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Molecular Weight

471.58

Formula

C₂₁H₄₅NO₁₀

CAS No.

1383658-09-0

SMILES

COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

m-PEG10-amineADC LinkerPROTAC LinkerAntibody-drug conjugates linkerPEGADCnon-cleavablelinkerPROTACInhibitorinhibitorinhibit

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m-PEG10-amine
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HY-140226
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