PEG10 Antibody (YA5015)
(Synonyms: PEG10; EDR; KIAA1051; MAR2; MART2; MEF3L1; RGAG3; Retrotransposon-derived protein PEG10; Embryonal carcinoma differentiation-regulated protein; Mammalian retrotransposon-derived protein 2; Myelin expression factor 3-like protein 1; MEF3-lik)PEG10 Antibody (YA5015) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to PEG10.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, IHC-P
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Reactivity :
Human
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Formulation:
Supplied in purified antibody in PBS with 0.05% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:100-1:200 |
Product Details
PEG10 Antibody (YA5015) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to PEG10.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 37,80 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 80 kDa
Purified recombinant fragment of human PEG10 expressed in E. Coli. The exact sequence is proprietary to MCE.
Endogenous
Ascitic Fluid
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in purified antibody in PBS with 0.05% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PEG10 is a Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids. Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA. Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region. Involved in placenta formation: required for trophoblast stem cells differentiation. Involved at the immediate early stage of adipocyte differentiation. Overexpressed in many cancers and enhances tumor progression: promotes cell proliferation by driving cell cycle progression from G0/G1. Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1. May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter; additional evidences are however required to confirm this result[1][2][3][4][5][6][7].
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Subcellular Localization
Extracellular vesicle membrane; Cytoplasm; Nucleus
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Expression
Tissue_specificity:It is expressed in the cytotrophoblast of the placenta, but not in the overlying syncytiotrophoblast. It is expressed in prostate and breast cancer, but not in normal breast and prostate epithelial cells. It is expressed in the Hep-G2 cell line (protein level) . It is expressed in the brain, liver, spleen, kidney, thymus, lung, ovary, testis, reactive lymph nodes, skeletal muscle, adipose tissue, and placenta. It is expressed in pancreatic cancer and hepatocellular carcinoma (HCC) .
Induction:Expression is directly regulated by E2F1 and E2F4, which bind to its promoter and direct its expression (PubMed:17050006, PubMed:18625225, PubMed:28193232, PubMed:28992046) . Up-regulated by MYC (PubMed:16423995) . Strongly overepressed in a number of tumors, such has hepatocellular carcinoma (HCC) , pancreatic or neuroendocrine prostate cancers (PubMed:20362226, PubMed:26235627, PubMed:28193232) -
Isoforms & Post-Translational Modification
Q86TG7 has 5 isomers: Q86TG7-1: 80173 Da (predicted); Q86TG7-2: 36966 Da (predicted); Q86TG7-3: 40490 Da (predicted); Q86TG7-4: 88281 Da (predicted); Q86TG7-5: 45074 Da (predicted).
Undergoes proteolytic cleavage -
Subunit
Homooligomer; homooligomerizes into virion-like capsids (By similarity). Interacts with ACVRL1 (PubMed:15611116). Interacts with SIAH1 and SIAH2 (PubMed:12810624)
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SwissProt ID
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Synonyms
PEG10; EDR; KIAA1051; MAR2; MART2; MEF3L1; RGAG3; Retrotransposon-derived protein PEG10; Embryonal carcinoma differentiation-regulated protein; Mammalian retrotransposon-derived protein 2; Myelin expression factor 3-like protein 1; MEF3-lik
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