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EXOC3 - exocyst complex component 3 Gene

Also Known as SEC6; Sec6p; SEC6L1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11336

About EXOC3

Cytogenetic location: 5p15.33 Genomic coordinates (GRCh38): 5:443,176-467,290 (from NCBI)

This gene has 10 transcripts (splice variants), 212 orthologues and 4 paralogues. Ubiquitous expression in colon (RPKM 23.5), kidney (RPKM 21.1) and 25 other tissues.

Summary

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. [provided by RefSeq, Jul 2008]

EXOC3 Products (1)

mRNA	Protein	Name
NM_007277.5	NP_009208.2	exocyst complex component 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18329369	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EXOC3 Protein Structure

Sec6

0
200
400
600
745 a.a.

Protein Preferred Names	Protein Names
exocyst complex component 3	SEC6-like 1

EXOC3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	EXOC3	O60645	GMCL1	Homo sapiens	Q96IK5	Y2H Prey Pooling	32296183
Intra	EXOC3	O60645	GMCL1	Homo sapiens	Q96IK5	Validated Y2H	32296183
Intra	EXOC3	O60645	GMCL1	Homo sapiens	Q96IK5	Y2H Array	32296183
Intra	EXOC3	O60645	FSD2	Homo sapiens	A1L4K1	Y2H Prey Pooling	32296183
Intra	EXOC3	O60645	FSD2	Homo sapiens	A1L4K1	Y2H Array	32296183
Intra	EXOC3	O60645	PPP1R12C	Homo sapiens	Q9BZL4	Y2H Prey Pooling	32296183
Intra	EXOC3	O60645	PPP1R12C	Homo sapiens	Q9BZL4	Validated Y2H	32296183
Intra	EXOC3	O60645	PPP1R12C	Homo sapiens	Q9BZL4	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

EXOC3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82142	Exocyst Complex Component 3 Antibody (YA1887)	WB, ICC/IF, IP	Human, Mouse, Rat
HY-P82142A	Exocyst Complex Component 3 Antibody (YA1887)(PBS only)	WB, ICC/IF, IP	Human, Mouse, Rat

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04589	EXOC3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	EXOC3	VGNC	VGNC:72409
Canis familiaris	EXOC3	VGNC	VGNC:103674
Mus musculus	EXOC3	MGD	MGI:2443972
Bos taurus	EXOC3	VGNC	VGNC:28645
Felis catus	EXOC3	VGNC	VGNC:61999
Rattus norvegicus	EXOC3	RGD	RGD:621790
Others	EXOC3	NCBI