Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
7741
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "7741" in MCE Product Catalog:
6
6 Publications Verification
Synonyms: ARRY-575; RG7741
Target:
Research Areas:
GDC-0575 (ARRY-575, RG7741) is a highly-selective oral small-molecule Chk1 inhibitor with an IC50 of 1.2 nM.
6
6 Publications Verification
Synonyms: ARRY-575 dihydrochloride; RG7741 dihydrochloride
Target:
Research Areas:
GDC-0575 dihydrochloride (ARRY-575 dihydrochloride) is an orally bioavailable CHK1 inhibitor, with an IC50 of 1.2 nM, and has antitumor activity.
2
2 Cited Publications
Target:
Research Areas:
STING agonist-12 (Compound 53) is a potent, orally active human STING activator with an EC50 of 185 nM .
Cat. No.: HY-N7741
CAS No.: 67667-64-5
Synonyms: Dehydrozaluzanin C-derivative
Target:
Cat. No.: HY-Z7741
CAS No.: 1276477-91-8
Target:
Research Areas:
Carvedilol impurity 3 is an impurity of Carvedilol.
Cat. No.: HY-N7005
CAS No.: 55804-74-5
Cat. No.: HY-112167B
CAS No.: 1196504-54-7
Synonyms: ARRY-575 hydrochloride; RG7741 hydrochloride
Target:
Research Areas:
GDC0575 (ARRY-575) hydrochloride is a highly-selective and orally active Chk1 (IC50=1.2 nM) inhibitor. GDC0575 (ARRY-575) hydrochloride can be used for colitis-associated cancer (CAC) and colitis research .
Cat. No.: HY-126489
CAS No.: 180027-84-3
Tetromycin B is a cysteine protease inhibitor with Ki values of 0.62, 1.42, 32.5, and 1.59 μM for rhodesain, falcipain-2, cathepsin L, and cathepsin B, respectively. It inhibits the growth of T. brucei in vitro (IC50=30.87 μM). Tetromycin B is also cytotoxic to HEK293T kidney cells and J774.1 macrophages (IC50s=71.77 and 20.2 μM, respectively).
Cat. No.: HY-178456
CAS No.: 3086122-36-0
Research Areas:
Antileishmanial agent-36 (compound 4f) is an indole-dihydropyrimidinone derivative with anti-leishmanial activity. Antileishmanial agent-36 induces reactive oxygen species (ROS)-mediated mitochondrial dysfunction and apoptosis. Antileishmanial agent-36 exhibits potent activity against L. donovani (IC50 =4.54 μM) with low cytotoxicity against J774.1 macrophage. Antileishmanial agent-36 clears the parasite burden in a visceral leishmaniasis (VL) model. Antileishmanial agent-36 can be used for VL research .
Cat. No.: HY-112167S
Synonyms: ARRY-575-d4; RG7741-d4
Cat. No.: HY-P88057A
Synonyms: CTLA-8; IL-17; IL-17A; IL17; ILA17
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
