TNIP2 - TNFAIP3 interacting protein 2 Gene

Also Known as KLIP; ABIN2; FLIP1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79155

About TNIP2

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:2,741,648-2,756,336 (from NCBI)

This gene has 7 transcripts (splice variants), 169 orthologues and 2 paralogues. Ubiquitous expression in small intestine (RPKM 12.1), colon (RPKM 11.5) and 25 other tissues.

Summary

This gene encodes a protein which acts as an inhibitor of NFkappaB activation. The encoded protein is also involved in MAP/ERK signaling pathway in specific cell types. It may be involved in Apoptosis of endothelial cells. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the X chromosome.[provided by RefSeq, May 2014]

TNIP2 Products (3)

mRNA Protein Name
NM_001161527.2 NP_001154999.1 TNFAIP3-interacting protein 2 isoform 2
NM_001292016.2 NP_001278945.1 TNFAIP3-interacting protein 2 isoform 3
NM_024309.4 NP_077285.3 TNFAIP3-interacting protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables polyubiquitin modification-dependent protein binding IDA
IDA: Inferred from direct assay
18212736 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12595760 GOA
enables protein kinase binding IDA
IDA: Inferred from direct assay
21784860 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of endothelial cell apoptotic process IDA
IDA: Inferred from direct assay
12933576 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
21784860 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12753905 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNIP2 Protein Structure

EABR

EABR: TSG101 and ALIX binding domain of CEP55 (214 - 246)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 429 a.a.
Protein Preferred Names Protein Names

TNFAIP3-interacting protein 2

  • A20-binding inhibitor of NF-kappaB activation-2

TNIP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TNIP2 Q8NFZ5 NFKB1 Homo sapiens P19838-1
Anti Bait CoIP
15169888
Intra
TNIP2 Q8NFZ5 NFKB1 Homo sapiens P19838-1
Pull Down
15169888
Intra
TNIP2 Q8NFZ5 STK11 Homo sapiens Q15831
Y2H
12753905
Intra
TNIP2 Q8NFZ5 REL Homo sapiens Q04864
TAP
14743216
Intra
TNIP2 Q8NFZ5 MAP3K8 Homo sapiens P41279
Anti Tag CoIP
15169888
Intra
TNIP2 Q8NFZ5 MAP3K8 Homo sapiens P41279
Pull Down
15169888
Intra
TNIP2 Q8NFZ5 MAP3K8 Homo sapiens P41279
TAP
14743216
Intra
TNIP2 Q8NFZ5 MAP3K8 Homo sapiens P41279
Anti Bait CoIP
15169888
Intra
TNIP2 Q8NFZ5 TNFAIP3 Homo sapiens P21580
Pull Down
15169888
Intra
TNIP2 Q8NFZ5 TNFAIP3 Homo sapiens P21580
ViroTrap
30561431
Intra
TNIP2 Q8NFZ5 TNFAIP3 Homo sapiens P21580
CoIP
11389905
Intra
TNIP2 Q8NFZ5 IKBKG Homo sapiens Q9Y6K9
Pull Down
14653779
Intra
TNIP2 Q8NFZ5 IKBKG Homo sapiens Q9Y6K9
ViroTrap
30561431
Intra
TNIP2 Q8NFZ5 IKBKG Homo sapiens Q9Y6K9
Y2H
21988832
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Rabies

  • Lyssa

  • Hydrophobia

  • St Hubert Disease
Thrombocytopenia

  • Low Platelet Count

  • Low Platelets

  • Decreased Platelets

  • Platelet Dysfunction Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14835 TNIP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22867 Tnip2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29381 Tnip2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TNIP2 VGNC VGNC:79182
Bos taurus TNIP2 VGNC VGNC:54503
Mus musculus TNIP2 MGD MGI:2386643
Felis catus TNIP2 VGNC VGNC:66417
Rattus norvegicus TNIP2 RGD RGD:1307717
Canis familiaris TNIP2 VGNC VGNC:47677
Others TNIP2 NCBI