BAD - BCL2 associated agonist of cell death Gene

Also Known as BBC2; BCL2L8

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 572

About BAD

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,269,828-64,284,704 (from NCBI)

This gene has 7 transcripts (splice variants) and 79 orthologues. Ubiquitous expression in colon (RPKM 20.0), fat (RPKM 18.4) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the Bcl-2 Family. Bcl-2 Family members are known to be regulators of programmed cell death. This protein positively regulates cell Apoptosis by forming heterodimers with Bcl-xL (B-cell lymphoma-extra large) and Bcl-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases Akt and MAP kinase, as well as protein phosphatase Calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Dec 2019]

BAD Products (2)

mRNA	Protein	Name
NM_004322.3	NP_004313.1	bcl2-associated agonist of cell death
NM_032989.3	NP_116784.1	bcl2-associated agonist of cell death

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cysteine-type endopeptidase activator activity involved in apoptotic process	IDA IDA: Inferred from direct assay	18402937	GOA
enables lipid binding	IDA IDA: Inferred from direct assay	19667065	GOA
enables phospholipid binding	IMP IMP: Inferred from mutant phenotype	21081150	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9388232	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	17270021	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in activation of cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	18387192	GOA
involved in apoptotic process	IDA IDA: Inferred from direct assay	19667065	GOA
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	20810912	GOA
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	19593445	GOA
involved in cellular response to nicotine	IDA IDA: Inferred from direct assay	18676776	GOA
involved in extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	18852119	GOA
involved in intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	18676776	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	18402937	GOA
involved in pore complex assembly	IDA IDA: Inferred from direct assay	19667065	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	9388232	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17289999	GOA
involved in positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	19593445	GOA
involved in positive regulation of proteolysis	IDA IDA: Inferred from direct assay	18387192	GOA
involved in positive regulation of release of cytochrome c from mitochondria	IMP IMP: Inferred from mutant phenotype	17289999	GOA
involved in regulation of mitochondrial membrane permeability	IMP IMP: Inferred from mutant phenotype	20700721	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of BAD-BCL-2 complex	IPI IPI: Inferred from physical interaction	9463381	GOA
located in cytosol	IDA IDA: Inferred from direct assay	20700721	GOA
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	20700721	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BAD Protein Structure

Bcl-2_BAD

0
100
168 a.a.

Protein Preferred Names	Protein Names
bcl2-associated agonist of cell death	BCL-X/BCL-2 binding protein

BAD Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BAD	Q92934	CAPN1	Homo sapiens	P07384	Validated Y2H	32814053
Intra	BAD	Q92934	CAPN1	Homo sapiens	P07384	Y2H Array	32814053
Intra	BAD	Q92934	CAPN1	Homo sapiens	P07384	Y2H Pooling	32814053
Intra	BAD	Q92934	BCL2L1	Homo sapiens	Q07817-1	Anti Bait CoIP	20603619
Intra	BAD	Q92934	BCL2L1	Homo sapiens	Q07817-1	Anti Tag CoIP	15131699
Intra	BAD	Q92934	BCL2L1	Homo sapiens	Q07817-1	Y2H	9388232
Intra	BAD	Q92934	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	31980649
Intra	BAD	Q92934	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	31980649
Intra	BAD	Q92934	YWHAZ	Homo sapiens	P63104	SPR	19667065
Intra	BAD	Q92934	YWHAZ	Homo sapiens	P63104	PLA	23397142
Intra	BAD	Q92934	YWHAZ	Homo sapiens	P63104	Y2H	21988832
Intra	BAD	Q92934	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	33961781
Intra	BAD	Q92934	YWHAE	Homo sapiens	P62258	Y2H Pooling	20936779
Intra	BAD	Q92934	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	31980649
Intra	BAD	Q92934	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	BAD	Q92934	YWHAB	Homo sapiens	P31946	Y2H	21900206
Intra	BAD	Q92934	YWHAB	Homo sapiens	P31946	Anti Tag CoIP	31980649
Intra	BAD	Q92934	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	31980649
Intra	BAD	Q92934	YWHAG	Homo sapiens	P61981	Y2H Pooling	20936779
Intra	BAD	Q92934	YWHAQ	Homo sapiens	P27348	Anti Tag CoIP	31980649
Intra	BAD	Q92934	YWHAQ	Homo sapiens	P27348	Confocal	21988832
Intra	BAD	Q92934	SFN	Homo sapiens	P31947	Anti Tag CoIP	31980649
Intra	BAD	Q92934	SFN	Homo sapiens	P31947	CoIP	20179209
Intra	BAD	Q92934	SFN	Homo sapiens	P31947	Y2H Pooling	16189514
Intra	BAD	Q92934	SFN	Homo sapiens	P31947	Anti Tag CoIP	33961781
Intra	BAD	Q92934	BCL2L11	Homo sapiens	O43521	Anti Bait CoIP	19427863
Intra	BAD	Q92934	BCL2L2	Homo sapiens	Q92843	SPR	15694340
Cross	BAD	Q92934	OPG035	vaccinia virus	P17361	Anti Tag CoIP	17485524
Intra	BAD	Q92934	BCL2	Homo sapiens	P10415	Anti Bait CoIP	17446862
Intra	BAD	Q92934	BCL2	Homo sapiens	P10415	ELISA	9388232
Intra	BAD	Q92934	BCL2	Homo sapiens	P10415	Anti Bait CoIP	9463381
Intra	BAD	Q92934	ACTN2	Homo sapiens	P35609	Y2H Array	32296183
Intra	BAD	Q92934	ACTN2	Homo sapiens	P35609	Y2H Prey Pooling	32296183
Intra	BAD	Q92934	BCL2L1	Homo sapiens	Q07817	Anti Tag CoIP	31980649
Intra	BAD	Q92934	BCL2L1	Homo sapiens	Q07817	Y2H Array	31515488
Intra	BAD	Q92934	BCL2L1	Homo sapiens	Q07817	MAPPIT	31467278
Intra	BAD	Q92934	BCL2L1	Homo sapiens	Q07817	Validated Y2H	25416956
Intra	BAD	Q92934	BCL2L1	Homo sapiens	Q07817	SLC	31467278
Intra	BAD	Q92934	BCL2L1	Homo sapiens	Q07817	BRET	29997244
Intra	BAD	Q92934	BCL2L1	Homo sapiens	Q07817	Lumier	32814053
Intra	BAD	Q92934	BCL2L1	Homo sapiens	Q07817	BRET	37398436
Intra	BAD	Q92934	BCL2L1	Homo sapiens	Q07817	Complementation	31467278
Intra	BAD	Q92934	BCL2L1	Homo sapiens	Q07817	Anti Bait CoIP	19427857
Intra	BAD	Q92934	BCL2L1	Homo sapiens	Q07817	Lumier	29997244
Intra	BAD	Q92934	BCL2L1	Homo sapiens	Q07817	PLA	25241761
Intra	BAD	Q92934	BNIP3L	Homo sapiens	O60238	Pull Down	9973195
Intra	BAD	Q92934	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	BAD	Q92934	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

BAD Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80025	Bad Antibody (YA593)	WB, ICC/IF, IHC-P, FC, IP	Human
HY-P83354	Phospho-Bad (Ser112) Antibody (YA3099)	WB, IP	Human, Mouse, Rat
HY-P86533	Bad Antibody (YA6225)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Transient Cerebral Ischemia	Transient Ischemic Attack Transient Ischemic Attacks Tia Tia - Transient Ischaemic Attack Transient Cerebral Ischaemia Ischemic Attack, Transient Intermittent Cerebral Ischemia Tia - [Transient Ischaemic Attack] Intermittent Cerebral Ischaemia Transient Cerebral Ischaemic Attack, Unspecified, Course Of Resolution Unspecified
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13495	ML281	Degrader	98.04%	Unkown
HY-N1983	Caudatin		99.95%	Unkown
HY-180190	Tubulin polymerization-IN-85		/	Unkown
HY-182937	FLC-8	Modulator	/	Unkown
HY-180948	PZ-11		/	Unkown
HY-181599	XAN-5		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	BAD	VGNC	VGNC:102738
Bos taurus	BAD	VGNC	VGNC:26404
Mus musculus	BAD	MGD	MGI:1096330
Canis familiaris	BAD	VGNC	VGNC:38362
Rattus norvegicus	BAD	RGD	RGD:620103
Macaca mulatta	BAD	VGNC	VGNC:70218
Others	BAD	NCBI