1. Cell Cycle/DNA Damage
  2. STK33
  3. ML281


Cat. No.: HY-13495 Purity: 99.88%
COA Handling Instructions

ML281 is a potent and selective STK33 inhibitor with IC50 of 14 nM.

For research use only. We do not sell to patients.

ML281 Chemical Structure

ML281 Chemical Structure

CAS No. : 1404437-62-2

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 119 In-stock
10 mM * 1 mL in DMSO USD 119 In-stock
5 mg USD 108 In-stock
10 mg USD 144 In-stock
50 mg USD 540 In-stock
100 mg USD 900 In-stock
200 mg USD 1320 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products

    ML281 purchased from MedChemExpress. Usage Cited in: Neoplasma. 2017;64(6):869-879.   [Abstract]

    Representative images and analysis results of western blotting validation after incubation with ML281.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review


    ML281 is a potent and selective STK33 inhibitor with IC50 of 14 nM. ML281 showed a 550-fold selectivity over AurB and greater than 700-fold selectivity over PKA. target: STK33 IC50: 14 nM [1] ML281 showed low nanomolar inhibition of purified recombinant STK33 and a distinct selectivity profile as compared to other STK33 inhibitors. Even at the highest concentration tested (10 μM), ML281 had no effect on the viability of KRAS-dependent cancer cells. [2]

    In Vitro

    ML281 (10 μM; 72 hours) suppresses cell viability of NCI-H446 cells[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[3]

    Cell Line: NCI-H446 cells
    Concentration: 10 μM
    Incubation Time: 72 hours
    Result: Suppressed cell viability of NCI-H446 cells.
    Molecular Weight




    CAS No.



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    Room temperature in continental US; may vary elsewhere.

    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (256.76 mM; Need ultrasonic)

    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.5676 mL 12.8380 mL 25.6759 mL
    5 mM 0.5135 mL 2.5676 mL 5.1352 mL
    10 mM 0.2568 mL 1.2838 mL 2.5676 mL
    *Please refer to the solubility information to select the appropriate solvent.
    Purity & Documentation
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    ML281 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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