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ML281 

Cat. No.: HY-13495 Purity: 99.98%
Handling Instructions

ML281 is a potent and selective STK33 inhibitor with IC50 of 14 nM.

For research use only. We do not sell to patients.

ML281 Chemical Structure

ML281 Chemical Structure

CAS No. : 1404437-62-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 119 In-stock
Estimated Time of Arrival: December 31
5 mg USD 108 In-stock
Estimated Time of Arrival: December 31
10 mg USD 144 In-stock
Estimated Time of Arrival: December 31
50 mg USD 540 In-stock
Estimated Time of Arrival: December 31
100 mg USD 900 In-stock
Estimated Time of Arrival: December 31
200 mg USD 1320 In-stock
Estimated Time of Arrival: December 31
500 mg   Get quote  
1 g   Get quote  

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Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products

    ML281 purchased from MCE. Usage Cited in: Neoplasma. 2017;64(6):869-879. 

    Representative images and analysis results of western blotting validation after incubation with ML281.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    ML281 is a potent and selective STK33 inhibitor with IC50 of 14 nM. ML281 showed a 550-fold selectivity over AurB and greater than 700-fold selectivity over PKA. target: STK33 IC50: 14 nM [1] ML281 showed low nanomolar inhibition of purified recombinant STK33 and a distinct selectivity profile as compared to other STK33 inhibitors. Even at the highest concentration tested (10 μM), ML281 had no effect on the viability of KRAS-dependent cancer cells. [2]

    In Vitro

    ML281 (10 μM; 72 hours) suppresses cell viability of NCI-H446 cells[3].

    Cell Viability Assay[3]

    Cell Line: NCI-H446 cells
    Concentration: 10 μM
    Incubation Time: 72 hours
    Result: Suppressed cell viability of NCI-H446 cells.
    Molecular Weight

    389.47

    Formula

    C₂₂H₁₉N₃O₂S

    CAS No.

    1404437-62-2

    SMILES

    O=C1NC2=CC=CC=C2N=C1C3=CC(C(C)C)=CC=C3NC(C4=CC=CS4)=O

    Shipping

    Room temperature in continental US; may vary elsewhere

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 30 mg/mL (77.03 mM)

    H2O : < 0.1 mg/mL (insoluble)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.5676 mL 12.8380 mL 25.6759 mL
    5 mM 0.5135 mL 2.5676 mL 5.1352 mL
    10 mM 0.2568 mL 1.2838 mL 2.5676 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (6.42 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (6.42 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    • Molarity Calculator

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    Product Name:
    ML281
    Cat. No.:
    HY-13495
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