Tubulin polymerization-IN-85
Tubulin polymerization-IN-85 (Compound C21) is a tubulin polymerization inhibitor (IC50 = 1.59 μM) targeting the colchicine binding site. Tubulin polymerization-IN-85 can cause cancer cells G2/M phase arrest and induce apoptosis. Tubulin polymerization-IN-85 downregulates the expression of Bcl-2, Bcl-xl, Mcl-1, Cyclin B1, cdc25, cdc2 protein and upregulates P53, P21, Bad and Bax levels. Tubulin polymerization-IN-85 can be used for the research of cancer, such as cervical cancer.
For research use only. We do not sell to patients.
- Formula: C20H19N3O4S
- Molecular Weight:397.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Bcl-2 |
Bcl-xL |
Bax |
Mcl-1 |
bad |
Cyclin B1 |
cdc25 |
cdc2 |
p21 |
Tubulin polymerization-IN-85 shows anti-proliferative activity against HeLa, HepG2, MCF-7 and A549 cells with IC50 values of 0.08, 0.21, 0.27 and 0.32 μM, while has low toxicity to normal renal epithelial 293T cells (IC50 = 187 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 397.45
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Formula C20H19N3O4S
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SMILES
COC1=C(OC)C(OC)=CC(CSC2=NN=C(C3=CNC4=C3C=CC=C4)O2)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tubulin polymerization-IN-85 Related Classifications
HY-180190 Related Classifications
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