1. Others Membrane Transporter/Ion Channel Autophagy
  2. Isotope-Labeled Compounds Potassium Channel Autophagy
  3. Desethyl Amiodarone-d4 hydrochloride

Desethyl Amiodarone-d4 (hydrochloride) is the deuterium labeled Desethylamiodarone hydrochloride. Desethylamiodarone hydrochloride (N-desethylamiodarone hydrochloride) is a major active metabolite of Amiodarone. Desethylamiodarone hydrochloride is formed by CYP3A isoenzymes. Amiodarone is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM[1][2][3].

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Desethyl Amiodarone-d<sub>4</sub> hydrochloride Chemical Structure

Desethyl Amiodarone-d4 hydrochloride Chemical Structure

CAS No. : 1189960-80-2

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Description

Desethyl Amiodarone-d4 (hydrochloride) is the deuterium labeled Desethylamiodarone hydrochloride. Desethylamiodarone hydrochloride (N-desethylamiodarone hydrochloride) is a major active metabolite of Amiodarone. Desethylamiodarone hydrochloride is formed by CYP3A isoenzymes. Amiodarone is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM[1][2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

657.74

Formula

C23H22D4ClI2NO3

CAS No.
SMILES

O=C(C1=CC(I)=C(C(I)=C1)OC([2H])([2H])C([2H])([2H])NCC)C2=C(CCCC)OC3=CC=CC=C23.Cl

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Desethyl Amiodarone-d4 hydrochloride Related Classifications

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Desethyl Amiodarone-d4 hydrochloride
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HY-130353S
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