Desethylamiodarone-d4 hydrochloride
Based on 1 Customer Validation
Desethylamiodarone-d4 hydrochloride (N-Desethylamiodarone-d4 hydrochloride; LB 33020-d4 hydrochloride) is the deuterated-labeled Desethylamiodarone hydrochloride (HY-130353). Desethylamiodarone hydrochloride (N-Desethylamiodarone hydrochloride; LB 33020 hydrochloride) is the major active metabolite of Amiodarone (HY-14187) generated via CYP3A4 metabolism. Desethylamiodarone hydrochloride downregulates p‑Akt, p‑Bad and Bcl‑2, upregulates Bax, promotes mitochondrial release of cytochrome c, activates caspase‑3 and cleaves PARP‑1, thereby inducing cell cycle arrest and apoptosis. Desethylamiodarone hydrochloride can be used in cervical cancer-related research.
For research use only. We do not sell to patients.
- CAS No.: 1189960-80-2
- Formula: C23H22D4ClI2NO3
- Molecular Weight:657.74
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
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CYP3A4 |
Caspase-3 |
PARP-1 |
Bax |
Bcl-2 |
bad |
Akt |
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1189960-80-2
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Unlabeled CAS 96027-74-6
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Molecular Weight 657.74
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Formula C23H22D4ClI2NO3
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SMILES
O=C(C1=CC(I)=C(C(I)=C1)OC([2H])([2H])C([2H])([2H])NCC)C2=C(CCCC)OC3=CC=CC=C23.Cl
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Synonyms
N-Desethylamiodarone-d4 hydrochloride; LB 33020-d4 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Desethylamiodarone-d4 hydrochloride Related Classifications
HY-130353S Related Classifications
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Keywords
- Desethylamiodarone-d4
- 1189960-80-2
- N-Desethylamiodarone-d4
- LB 33020-d4
- Isotope-Labeled Compounds
- Drug Metabolite
- Cytochrome P450
- Akt
- Bcl-2 Family
- Caspase
- PARP
- Apoptosis
- phosphorylated Akt
- Bax
- proliferation
- HeLa human cervical cancer cells
- blood-brain barrier
- phosphorylated Bad
- apoptosis
- Bcl-2
- PI3K-Akt signaling
- SGHTL-34 human thyrocytes
- Inhibitor
- inhibitor
- inhibit