Desethylamiodarone hydrochloride (Standard)
Desethylamiodarone hydrochloride (Standard) (N-Desethylamiodarone hydrochloride (Standard); LB 33020 hydrochloride (Standard)) is the analytical standard of Desethylamiodarone hydrochloride (HY-130353). This product is intended for research and analytical applications. Desethylamiodarone hydrochloride (N-Desethylamiodarone hydrochloride; LB 33020 hydrochloride) is the major active metabolite of Amiodarone (HY-14187) generated via CYP3A4 metabolism. Desethylamiodarone hydrochloride downregulates p‑Akt, p‑Bad and Bcl‑2, upregulates Bax, promotes mitochondrial release of cytochrome c, activates caspase‑3 and cleaves PARP‑1, thereby inducing cell cycle arrest and apoptosis. Desethylamiodarone hydrochloride can be used in cervical cancer-related research.
For research use only. We do not sell to patients.
- CAS No.: 96027-74-6
- Formula: C23H26ClI2NO3
- Molecular Weight:653.72
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
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HY-130353
Desethylamiodarone hydrochloride -
HY-14187
Amiodarone -
HY-14188
Amiodarone hydrochloride -
HY-113147A
L-Palmitoylcarnitine chloride -
HY-14188R
Amiodarone hydrochloride (Standard) -
HY-120358
L-6424 -
HY-124176
L-6355 -
HY-116478
L-3373 -
HY-W700643
Di-N-desethyl amiodarone hydrochloride -
HY-113147AR
L-Palmitoylcarnitine chloride (Standard)
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 96027-74-6
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Molecular Weight 653.72
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Formula C23H26ClI2NO3
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SMILES
O=C(C1=C(CCCC)OC2=CC=CC=C12)C3=CC(I)=C(OCCNCC)C(I)=C3.[H]Cl
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Synonyms
N-Desethylamiodarone hydrochloride (Standard); LB 33020 hydrochloride (Standard)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Desethylamiodarone hydrochloride (Standard) Related Classifications
HY-130353R Related Classifications
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Keywords
- Desethylamiodarone hydrochloride (Standard)
- 96027-74-6
- N-Desethylamiodarone hydrochloride (Standard)
- LB 33020 hydrochloride (Standard)
- Reference Standards
- Drug Metabolite
- Cytochrome P450
- Akt
- Bcl-2 Family
- Caspase
- PARP
- Apoptosis
- phosphorylated Akt
- Bax
- proliferation
- HeLa human cervical cancer cells
- blood-brain barrier
- phosphorylated Bad
- apoptosis
- Bcl-2
- PI3K-Akt signaling
- SGHTL-34 human thyrocytes
- Inhibitor
- inhibitor
- inhibit