1. Membrane Transporter/Ion Channel
    Metabolic Enzyme/Protease
  2. Potassium Channel
    Endogenous Metabolite
  3. L-Palmitoylcarnitine chloride

L-Palmitoylcarnitine chloride 

Cat. No.: HY-113147A Purity: ≥98.0%
Handling Instructions

L-Palmitoylcarnitine chloride, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine chloride inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2.

For research use only. We do not sell to patients.

L-Palmitoylcarnitine chloride Chemical Structure

L-Palmitoylcarnitine chloride Chemical Structure

CAS No. : 18877-64-0

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10 mM * 1 mL in DMSO USD 110 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

L-Palmitoylcarnitine chloride, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine chloride inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2[1].

IC50 & Target[1]

Kir6.2

 

Human Endogenous Metabolite

 

In Vitro

L-Palmitoylcarnitine (1 µM) inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2. L-Palmitoylcarnitine simultaneously enhances the ATP sensitivity of the channel (IC50 fell from 62 to 30 µM)[1].
Modulation of the membrane lipid environment caused by L-Palmitoylcarnitine alters the KATP channel function mainly through the interaction with endogenous PI cascade, especially PIP2[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

436.07

Formula

C₂₃H₄₆ClNO₄

CAS No.

18877-64-0

SMILES

CCCCCCCCCCCCCCCC(O[[email protected]](CC(O)=O)C[N+](C)(C)C)=O.[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (114.66 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2932 mL 11.4660 mL 22.9321 mL
5 mM 0.4586 mL 2.2932 mL 4.5864 mL
10 mM 0.2293 mL 1.1466 mL 2.2932 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.08 mg/mL (4.77 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (4.77 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: 2.08 mg/mL (4.77 mM); Clear solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
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Keywords:

L-PalmitoylcarnitinePotassium ChannelEndogenous MetaboliteKcsAfattyacidmetaboliteischaemialipidInhibitorinhibitorinhibit

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Product Name:
L-Palmitoylcarnitine chloride
Cat. No.:
HY-113147A
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