1. Membrane Transporter/Ion Channel
    Metabolic Enzyme/Protease
  2. Potassium Channel
    Endogenous Metabolite
  3. L-Palmitoylcarnitine

L-Palmitoylcarnitine 

Cat. No.: HY-113147
Handling Instructions

L-Palmitoylcarnitine, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2.

For research use only. We do not sell to patients.

L-Palmitoylcarnitine Chemical Structure

L-Palmitoylcarnitine Chemical Structure

CAS No. : 2364-67-2

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Description

L-Palmitoylcarnitine, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2[1].

IC50 & Target[1]

Kir6.2

 

Human Endogenous Metabolite

 

In Vitro

L-Palmitoylcarnitine (1 µM) inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2. L-Palmitoylcarnitine simultaneously enhances the ATP sensitivity of the channel (IC50 fell from 62 to 30 µM)[1].
Modulation of the membrane lipid environment caused by L-Palmitoylcarnitine alters the KATP channel function mainly through the interaction with endogenous PI cascade, especially PIP2[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

399.61

Formula

C₂₃H₄₅NO₄

CAS No.
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Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (625.61 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5024 mL 12.5122 mL 25.0244 mL
5 mM 0.5005 mL 2.5024 mL 5.0049 mL
10 mM 0.2502 mL 1.2512 mL 2.5024 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.21 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.21 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: ≥97.0%

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L-Palmitoylcarnitine
Cat. No.:
HY-113147
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