CRTC3 - CREB regulated transcription coactivator 3 Gene

Also Known as TORC3; TORC-3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64784

About CRTC3

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:90,529,923-90,645,345 (from NCBI)

This gene has 18 transcripts (splice variants), 200 orthologues, 2 paralogues and is associated with 66 phenotypes. Ubiquitous expression in ovary (RPKM 20.6), fat (RPKM 11.8) and 25 other tissues.

Summary

This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate Catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

CRTC3 Products (2)

mRNA Protein Name
NM_001042574.3 NP_001036039.1 CREB-regulated transcription coactivator 3 isoform b
NM_022769.5 NP_073606.3 CREB-regulated transcription coactivator 3 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20936779 GOA
Biological Process GO Annotation Evidence References Source
involved in macrophage activation IMP
IMP: Inferred from mutant phenotype
23033494 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRTC3 Protein Structure

TORC_N

TORC_N: Transducer of regulated CREB activity, N terminus (11 - 64)

TORC_M

TORC_M: Transducer of regulated CREB activity middle domain (159 - 322)

TORC_C

TORC_C: Transducer of regulated CREB activity, C terminus (545 - 619)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 619 a.a.
Protein Preferred Names Protein Names

CREB-regulated transcription coactivator 3

  • transducer of regulated CREB protein 3

CRTC3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CRTC3 Q6UUV7 CA13 Homo sapiens Q8N1Q1
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

CRTC3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82003 CRTC3 Antibody (YA1748) WB, ICC/IF Human, Mouse, Rat
HY-P82003A CRTC3 Antibody (YA1748)(PBS only) WB, ICC/IF Human, Mouse, Rat
HY-P84643 CRTC3 Antibody (YA4340) WB, IHC-P, ICC/IF, ELISA Human, Monkey
HY-P84643A CRTC3 Antibody (YA4340)(PBS only) WB, IHC-P, ICC/IF, ELISA Human, Monkey
HY-P85394 TORC3 Antibody (YA5086) WB; IHC-P; IHC-F; ICC/IF; IF-Tissue Human, Mouse, Rat

Related Diseases

Diseases Alias
Human T-Cell Leukemia Virus Type 1

  • Htlv-1

  • Human T Lymphotropic Virus Type 1
Esophageal Adenoid Cystic Carcinoma

  • Adenoid Cystic Carcinoma, Esophagus
Salivary Gland Carcinoma

  • Salivary Gland Cancer

  • Malignant Neoplasm Of Salivary Gland

  • Salivary Gland Neoplasms
Lacrimal Gland Mucoepidermoid Carcinoma

  • Mucoepidermoid Carcinoma Of The Lacrimal Gland
Hidradenoma

  • Adenoma, Sweat Gland

  • Hidradenoma Of Skin

  • Sweat Gland Adenoma

  • Syringoadenoma

  • Eccrine Acrospiroma

  • Benign Neoplasm Of Sweat Gland
Pleomorphic Adenoma Carcinoma

  • Carcinoma Ex Pleomorphic Adenoma

  • Carcinoma In Pleomorphic Adenoma
Salivary Gland Disease

  • Salivary Gland Disorders

  • Salivary Gland Diseases

  • Non-Neoplastic Salivary Gland Disease

  • Non-Neoplastic Salivary Gland Disorder

  • Disorder Of Salivary Gland

  • Lesion Of Salivary Gland Nos
Epithelial-Myoepithelial Carcinoma

  • Clear Cell Adenoma

  • Adenomyo-Epithelioma

  • Clear Cell Carcinoma

  • Emc

  • Epithelial Myoepithelial Carcinoma

  • Glycogen-Rich Adenocarcinoma

  • Glycogen-Rich Adenoma

  • Monomorphic Clear Cell Tumor

  • Tubular Solid Adenoma

  • Adenocarcinoma, Clear Cell
Clear Cell Hidradenoma

  • Clear Cell Myoepithelioma

  • Eccrine Acrospiroma
Tonsil Cancer

  • Tonsillar Neoplasms

  • Malignant Neoplasm Of Faucial Tonsil

  • Malignant Neoplasm Of Palatine Tonsil

  • Malignant Neoplasm Of Tonsil, Faucial

  • Malignant Tonsillar Tumor

  • Malignant Tumor Of Tonsil

  • Tonsillar Carcinoma

  • Malignant Neoplasm Tonsil
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-120877 MRT199665 99.85% Unkown
HY-120877A (R)-MRT199665 98.70% Unkown
HY-171591 SIK2-IN-4 Inhibitor 99.06% Unkown
HY-171590 SIK2-IN-3 Inhibitor / Unkown
HY-RS03202 CRTC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CRTC3 VGNC VGNC:61194
Bos taurus CRTC3 VGNC VGNC:27729
Rattus norvegicus CRTC3 RGD RGD:1309666
Mus musculus CRTC3 MGD MGI:1917711
Canis familiaris CRTC3 VGNC VGNC:53163
Macaca mulatta CRTC3 VGNC VGNC:71584
Others CRTC3 NCBI