SIK2-IN-3
SIK2-IN-3 is an orally active SIK1/2 selective inhibitor (IC50: 0.128/0.084 μM). SIK2-IN-3 inhibits CRTC3 phosphorylation and myeloid cell pro-inflammatory cytokine production. SIK2-IN-3 ameliorates systemic and tissue inflammatory responses in a mouse anti-CD40 colitis model.
For research use only. We do not sell to patients.
- CAS No.: 2810809-10-8
- Formula: C23H24N6O2
- Molecular Weight:416.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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SIK2 0.084 μM (IC50) |
SIK1 0.128 μM (IC50) |
Chemical Information
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CAS No. 2810809-10-8
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Molecular Weight 416.48
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Formula C23H24N6O2
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SMILES
CN(C1)CC[C@H]1COC2=CN=C(C#N)C=C2C3=CC4=CC(NC(C5CC5)=O)=NN4C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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