2. Gene
  3. MARK2 - microtubule affinity regulating kinase 2 Gene

MARK2 - microtubule affinity regulating kinase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as EMK1; EMK-1; PAR-1; Par1b; Par-1b

Gene ID: 2011 | Gene type: protein coding

About MARK2

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:63,839,110-63,911,020 (from NCBI)

This gene has 23 transcripts (splice variants), 236 orthologues and 3 paralogues. Ubiquitous expression in esophagus (RPKM 11.9), colon (RPKM 10.6) and 25 other tissues.

Summary

This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]

MARK2 Products(5)

mRNA Protein Name
NM_001039469.3 NP_001034558.2 serine/threonine-protein kinase MARK2 isoform d
NM_001163296.2 NP_001156768.1 serine/threonine-protein kinase MARK2 isoform e
NM_001163297.2 NP_001156769.1 serine/threonine-protein kinase MARK2 isoform f
NM_004954.5 NP_004945.4 serine/threonine-protein kinase MARK2 isoform c
NM_017490.4 NP_059672.2 serine/threonine-protein kinase MARK2 isoform a

MARK2 Protein Structure

Pkinase

Pkinase: Protein kinase domain (53 - 304)

KA1

KA1: Kinase associated domain 1 (745 - 788)

  • 0
  • 200
  • 400
  • 600
  • 788 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase MARK2

ELKL motif kinase 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-139604 PCC0208017 Inducer 98.03% Unkown
HY-120877 MRT199665 99.92% Unkown
HY-148062 RSS0680 98.03% Unkown
HY-RS08150 MARK2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MARK2 VGNC VGNC:74634
Canis familiaris MARK2 VGNC VGNC:43024
Mus musculus MARK2 MGD MGI:99638
Bos taurus MARK2 VGNC VGNC:31248
Rattus norvegicus MARK2 RGD RGD:708483
Felis catus MARK2 VGNC VGNC:63389