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MARK2 - microtubule affinity regulating kinase 2 Gene

Also Known as EMK1; EMK-1; PAR-1; Par1b; Par-1b

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2011

About MARK2

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:63,839,110-63,911,020 (from NCBI)

This gene has 23 transcripts (splice variants), 236 orthologues and 3 paralogues. Ubiquitous expression in esophagus (RPKM 11.9), colon (RPKM 10.6) and 25 other tissues.

Summary

This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]

MARK2 Products (5)

mRNA	Protein	Name
NM_001039469.3	NP_001034558.2	serine/threonine-protein kinase MARK2 isoform d
NM_001163296.2	NP_001156768.1	serine/threonine-protein kinase MARK2 isoform e
NM_001163297.2	NP_001156769.1	serine/threonine-protein kinase MARK2 isoform f
NM_004954.5	NP_004945.4	serine/threonine-protein kinase MARK2 isoform c
NM_017490.4	NP_059672.2	serine/threonine-protein kinase MARK2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	14976552	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	14976552	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14676191	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	14976552	GOA
enables tau-protein kinase activity	IMP IMP: Inferred from mutant phenotype	23666762	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in establishment of cell polarity	IDA IDA: Inferred from direct assay	12429843	GOA
involved in establishment or maintenance of epithelial cell apical/basal polarity	IDA IDA: Inferred from direct assay	15324659	GOA
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	14976552	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	10542369	GOA
involved in positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	12429843	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	14976552	GOA
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	23666762	GOA
involved in regulation of axonogenesis	IMP IMP: Inferred from mutant phenotype	20194617	GOA
involved in regulation of microtubule cytoskeleton organization	IDA IDA: Inferred from direct assay	10542369	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in actin filament	IDA IDA: Inferred from direct assay	23902687	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	23666762	GOA
located in dendrite	IDA IDA: Inferred from direct assay	23666762	GOA
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	23902687	GOA
located in membrane	IMP IMP: Inferred from mutant phenotype	14976552	GOA
located in microtubule bundle	IDA IDA: Inferred from direct assay	23902687	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	23902687	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MARK2 Protein Structure

Pkinase

KA1

0
200
400
600
788 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase MARK2	ELKL motif kinase 1

MARK2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MARK2	Q7KZI7	PARD6G	Homo sapiens	Q9BYG4	Anti Tag CoIP	14676191
Intra	MARK2	Q7KZI7	YWHAH	Homo sapiens	Q04917	Pull Down	32707033
Intra	MARK2	Q7KZI7	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	35271311
Intra	MARK2	Q7KZI7	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	19615732
Intra	MARK2	Q7KZI7	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	MARK2	Q7KZI7	YWHAZ	Homo sapiens	P63104	TAP	16306228
Intra	MARK2	Q7KZI7	YWHAZ	Homo sapiens	P63104	Pull Down	32707033
Intra	MARK2	Q7KZI7	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	35271311
Intra	MARK2	Q7KZI7	YWHAB	Homo sapiens	P31946	Pull Down	32707033
Intra	MARK2	Q7KZI7	YWHAB	Homo sapiens	P31946	Anti Tag CoIP	16959763
Intra	MARK2	Q7KZI7	YWHAB	Homo sapiens	P31946	Anti Tag CoIP	35271311
Intra	MARK2	Q7KZI7	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	35271311
Intra	MARK2	Q7KZI7	YWHAG	Homo sapiens	P61981	Pull Down	32707033
Intra	MARK2	Q7KZI7	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	16959763
Cross	MARK2	Q7KZI7	cagA	Helicobacter pylori	P55980	X-Ray Diffraction	19966800
Cross	MARK2	Q7KZI7	cagA	Helicobacter pylori	P55980	GMS	19966800
Cross	MARK2	Q7KZI7	cagA	Helicobacter pylori	P55980	Pull Down	19966800
Cross	MARK2	Q7KZI7	cagA	Helicobacter pylori	P55980	SLCA	19966800

Cross: Cross-species interaction Intra: Intraspecies interaction

MARK2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82359	MARK2 Antibody (YA2104)	WB, FC	Human, Mouse, Rat

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-182743	OICR19451	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MARK2	VGNC	VGNC:74634
Canis familiaris	MARK2	VGNC	VGNC:43024
Mus musculus	MARK2	MGD	MGI:99638
Bos taurus	MARK2	VGNC	VGNC:31248
Rattus norvegicus	MARK2	RGD	RGD:708483
Felis catus	MARK2	VGNC	VGNC:63389
Others	MARK2	NCBI