ZFP36L1 - ZFP36 ring finger protein like 1 Gene

Homo sapiens

Also known as BRF1; ERF1; cMG1; ERF-1; Berg36; TIS11B; RNF162B

Gene ID: 677 | Gene type: protein coding

About ZFP36L1

Cytogenetic location: 14q24.1 Genomic coordinates (GRCh38): 14:68,787,655-68,796,243 (from NCBI)

This gene has 6 transcripts (splice variants), 247 orthologues and 2 paralogues. Ubiquitous expression in endometrium (RPKM 164.2), ovary (RPKM 123.6) and 25 other tissues.

Summary

This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

ZFP36L1 Products(3)

mRNA	Protein	Name
NM_001244698.2	NP_001231627.1	mRNA decay activator protein ZFP36L1 isoform 1
NM_001244701.1	NP_001231630.1	mRNA decay activator protein ZFP36L1 isoform 2
NM_004926.4	NP_004917.2	mRNA decay activator protein ZFP36L1 isoform 1

ZFP36L1 Protein Structure

Tis11B_N

zf-CCCH

0
100
200
300
338 a.a.

Protein Preferred Names

Protein Names

mRNA decay activator protein ZFP36L1

EGF-response factor 1

Related Diseases

Diseases

Alias

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16041	ZFP36L1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ZFP36L1	VGNC	VGNC:99347
Canis familiaris	ZFP36L1	VGNC	VGNC:48613
Mus musculus	ZFP36L1	MGD	MGI:107946
Felis catus	ZFP36L1	VGNC	VGNC:67231
Bos taurus	ZFP36L1	VGNC	VGNC:37163
Rattus norvegicus	ZFP36L1	RGD	RGD:62009

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