ITPRID2 - ITPR interacting domain containing 2 Gene

Also Known as CS1; CS-1; KRAP; SSFA2; SPAG13

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6744

About ITPRID2

Cytogenetic location: 2q31.3 Genomic coordinates (GRCh38): 2:181,891,730-181,930,738 (from NCBI)

This gene has 15 transcripts (splice variants), 209 orthologues and 2 paralogues. Ubiquitous expression in skin (RPKM 31.5), colon (RPKM 22.4) and 25 other tissues.

Summary

Enables actin filament binding activity. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

ITPRID2 Products (5)

mRNA Protein Name
NM_001130445.3 NP_001123917.1 protein ITPRID2 isoform 1
NM_001287503.2 NP_001274432.1 protein ITPRID2 isoform 3
NM_001287504.2 NP_001274433.1 protein ITPRID2 isoform 4
NM_001287505.2 NP_001274434.1 protein ITPRID2 isoform 5
NM_006751.7 NP_006742.2 protein ITPRID2 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables actin filament binding IDA
IDA: Inferred from direct assay
14673706 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20936779 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITPRID2 Protein Structure

KRAP_IP3R_bind

KRAP_IP3R_bind: Ki-ras-induced actin-interacting protein-IP3R-interacting domain (146 - 290)

SSFA2_C

SSFA2_C: Sperm-specific antigen 2 C-terminus (861 - 1033)

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  • 1259 a.a.
Protein Preferred Names Protein Names

protein ITPRID2

  • ITPR-interacting domain-containing protein 2

ITPRID2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ITPRID2 P28290 YWHAE Homo sapiens P62258
Y2H Pooling
20936779
Intra
ITPRID2 P28290 YWHAQ Homo sapiens P27348
Y2H
21988832
Intra
ITPRID2 P28290 SGF29 Homo sapiens Q96ES7
Anti Tag CoIP
33961781
Intra
ITPRID2 P28290 SGF29 Homo sapiens Q96ES7
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06994 ITPRID2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ITPRID2 MGD MGI:1917849
Bos taurus ITPRID2 VGNC VGNC:35311
Felis catus ITPRID2 VGNC VGNC:62988
Macaca mulatta ITPRID2 VGNC VGNC:73584
Rattus norvegicus ITPRID2 RGD RGD:1310767
Canis familiaris ITPRID2 VGNC VGNC:46830
Others ITPRID2 NCBI