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RIMS3 - regulating synaptic membrane exocytosis 3 Gene

Also Known as NIM3; RIM3; RIM 3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9783

About RIMS3

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:40,620,680-40,692,066 (from NCBI)

This gene has 2 transcripts (splice variants), 206 orthologues and 4 paralogues. Biased expression in brain (RPKM 26.0), adrenal (RPKM 4.0) and 9 other tissues.

Summary

Predicted to enable transmembrane transporter binding activity. Predicted to be involved in several processes, including calcium ion-regulated exocytosis of neurotransmitter; modulation of chemical synaptic transmission; and regulation of synapse organization. Predicted to be located in presynaptic active zone. Predicted to be part of glutamatergic synapse. Predicted to be active in Cytoskeleton of presynaptic active zone; postsynaptic cytosol; and presynaptic membrane. [provided by Alliance of Genome Resources, Apr 2022]

RIMS3 Products (1)

mRNA	Protein	Name
NM_014747.3	NP_055562.2	regulating synaptic membrane exocytosis protein 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RIMS3 Protein Structure

0
100
200
308 a.a.

Protein Preferred Names	Protein Names
regulating synaptic membrane exocytosis protein 3	RIM3 gamma

RIMS3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RIMS3	Q9UJD0	COMT	Homo sapiens	P21964-2	Y2H Array	32814053
Intra	RIMS3	Q9UJD0	COMT	Homo sapiens	P21964-2	Y2H Pooling	32814053
Intra	RIMS3	Q9UJD0	COMT	Homo sapiens	P21964-2	Validated Y2H	32814053
Intra	RIMS3	Q9UJD0	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	RIMS3	Q9UJD0	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	RIMS3	Q9UJD0	VIM	Homo sapiens	P08670	Validated Y2H	32814053
Intra	RIMS3	Q9UJD0	VIM	Homo sapiens	P08670	Y2H Array	32814053
Intra	RIMS3	Q9UJD0	VIM	Homo sapiens	P08670	Y2H Pooling	32814053
Intra	RIMS3	Q9UJD0	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
Intra	RIMS3	Q9UJD0	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
Intra	RIMS3	Q9UJD0	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
Intra	RIMS3	Q9UJD0	KAT5	Homo sapiens	Q92993	Validated Y2H	32814053
Intra	RIMS3	Q9UJD0	KAT5	Homo sapiens	Q92993	Y2H Pooling	32814053
Intra	RIMS3	Q9UJD0	KAT5	Homo sapiens	Q92993	Y2H Array	32814053
Intra	RIMS3	Q9UJD0	PECAM1	Homo sapiens	P16284	Y2H Array	32814053
Intra	RIMS3	Q9UJD0	PECAM1	Homo sapiens	P16284	Y2H Pooling	32814053
Intra	RIMS3	Q9UJD0	PECAM1	Homo sapiens	P16284	Validated Y2H	32814053
Intra	RIMS3	Q9UJD0	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	RIMS3	Q9UJD0	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	RIMS3	Q9UJD0	HLA-A	Homo sapiens	Q5SUL5	Y2H Array	32814053
Intra	RIMS3	Q9UJD0	HLA-A	Homo sapiens	Q5SUL5	Y2H Pooling	32814053
Intra	RIMS3	Q9UJD0	HLA-A	Homo sapiens	Q5SUL5	Validated Y2H	32814053
Intra	RIMS3	Q9UJD0	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Intra	RIMS3	Q9UJD0	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053
Intra	RIMS3	Q9UJD0	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Aortic Valve Prolapse
Heimler Syndrome 2	HMLR2 Peroxisome Biogenesis Disorder 4c Pbd4c Peroxisomal Biogenesis Disorder 4c Heimler Syndrome, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11980	RIMS3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RIMS3	VGNC	VGNC:33973
Canis familiaris	RIMS3	VGNC	VGNC:45584
Rattus norvegicus	RIMS3	RGD	RGD:628762
Felis catus	RIMS3	VGNC	VGNC:64632
Mus musculus	RIMS3	MGD	MGI:2443331
Macaca mulatta	RIMS3	VGNC	VGNC:106487
Others	RIMS3	NCBI