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MNDA - myeloid cell nuclear differentiation antigen Gene

Also Known as PYHIN3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4332

About MNDA

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:158,831,351-158,849,502 (from NCBI)

This gene has 3 transcripts (splice variants), 48 orthologues and 3 paralogues. Biased expression in bone marrow (RPKM 108.7), appendix (RPKM 52.2) and 7 other tissues.

Summary

The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. [provided by RefSeq, Jul 2008]

MNDA Products (1)

mRNA	Protein	Name
NM_002432.3	NP_002423.1	myeloid cell nuclear differentiation antigen

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23455924	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in B cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17875758	GOA
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	17875758	GOA
involved in negative regulation of B cell proliferation	IMP IMP: Inferred from mutant phenotype	17875758	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17875758	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MNDA Protein Structure

PYRIN

HIN

0
100
200
300
407 a.a.

Protein Preferred Names	Protein Names
myeloid cell nuclear differentiation antigen	epididymis secretory sperm binding protein

MNDA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MNDA	P41218	MET	Homo sapiens	P08581	Validated Y2H	32814053
Intra	MNDA	P41218	MET	Homo sapiens	P08581	Y2H Array	32814053
Intra	MNDA	P41218	MET	Homo sapiens	P08581	Y2H Pooling	32814053
Intra	MNDA	P41218	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	MNDA	P41218	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	MNDA	P41218	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	MNDA	P41218	NSD3	Homo sapiens	Q9BZ95	Y2H	23455924
Intra	MNDA	P41218	NSD3	Homo sapiens	Q9BZ95	Anti Tag CoIP	23455924
Intra	MNDA	P41218	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	MNDA	P41218	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	MNDA	P41218	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	MNDA	P41218	A2M	Homo sapiens	P01023	Validated Y2H	32814053
Intra	MNDA	P41218	A2M	Homo sapiens	P01023	Y2H Array	32814053
Intra	MNDA	P41218	A2M	Homo sapiens	P01023	Y2H Pooling	32814053
Intra	MNDA	P41218	TTR	Homo sapiens	P02766	Validated Y2H	32814053
Intra	MNDA	P41218	TTR	Homo sapiens	P02766	Y2H Pooling	32814053
Intra	MNDA	P41218	TTR	Homo sapiens	P02766	Y2H Array	32814053
Intra	MNDA	P41218	NDUFV1	Homo sapiens	P49821	Validated Y2H	32814053
Intra	MNDA	P41218	NDUFV1	Homo sapiens	P49821	Y2H Array	32814053
Intra	MNDA	P41218	NDUFV1	Homo sapiens	P49821	Y2H Pooling	32814053
Intra	MNDA	P41218	PEX1	Homo sapiens	O43933	Y2H Array	32814053
Intra	MNDA	P41218	PEX1	Homo sapiens	O43933	Validated Y2H	32814053
Intra	MNDA	P41218	PEX1	Homo sapiens	O43933	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Myeloid Leukemia	Myeloid Leukaemia Leukaemia Myelogenous Leukemia Myelogenous Myeloid Granulocytic Leukaemia Myeloid Granulocytic Leukemia Non-Lymphocytic Leukemia Leukemia, Myeloid Granulocytic Leukaemia Myelogenous Leukaemia Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Methotrexate-Associated Lymphoproliferation
Nodal Marginal Zone Lymphoma	Mucosa-Associated Lymphoid Tissue Lymphoma Monocytoid B-Cell Lymphoma
Parkinson Disease 4, Autosomal Dominant	Autosomal Dominant Parkinson Disease 4 PARK4 Parkinson Disease 4, Autosomal Dominant Lewy Body Parkinson Disease 4 Parkinson'S Disease 4 Autosomal Dominant Lewy Body Parkinson Disease 4 Autosomal Dominant Parkinson'S Disease 4 Parkinson Disease 4 Autosomal Dominant Lewy Body Parkinson Disease Autosomal Dominant 4 Parkinson Disease Familial Type 4 Parkinson Disease, Type 4
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Parkinson Disease 2, Autosomal Recessive Juvenile	Young-Onset Parkinson Disease PARK2 Pdj Autosomal Recessive Juvenile Parkinson Disease 2 Epdf Parkinson Disease, Juvenile, Type 2 Parkinson'S Disease 2 Autosomal Recessive Juvenile Parkinson Disease Early-Onset Parkinson Disease Parkinson Disease 2 Parkinson Disease, Juvenile, Autosomal Recessive Parkinsonism, Early-Onset, With Diurnal Fluctuation Autosomal Recessive Juvenile Parkinson'S Disease 2 Jp Juvenile Parkinsonism Parkinson Disease Autosomal Recessive, Early Onset Parkinsonism, Early Onset, With Diurnal Fluctuation Yopd Autosomal Recessive Early-Onset Parkinson Disease Type 2 Chromosome 6-Linked Autosomal Recessive Parkinsonism Early-Onset Parkinsonism With Diurnal Fluctuation Parkinsonism Young Adult Onset Parkinson Disease, Type 2 Parkinsonism, Juvenile
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-160018	BAY-155	Inhibitor	/	Unkown
HY-RS08568	MNDA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26420	Mnda Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MNDA	VGNC	VGNC:53122
Macaca mulatta	MNDA	VGNC	VGNC:74906
Others	MNDA	NCBI