HIVEP2 - HIVEP zinc finger 2 Gene

Also Known as SHN2; ZAS2; MBP-2; MIBP1; MRD43; ZNF40B; HIV-EP2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3097

About HIVEP2

Cytogenetic location: 6q24.2 Genomic coordinates (GRCh38): 6:142,751,469-142,946,365 (from NCBI)

This gene has 10 transcripts (splice variants), 272 orthologues, 14 paralogues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 14.4), ovary (RPKM 8.2) and 25 other tissues.

Summary

This gene encodes a member of a family of closely related, large, zinc finger-containing transcription factors. The encoded protein regulates transcription by binding to regulatory regions of various cellular and viral genes that maybe involved in growth, development and metastasis. The protein contains the ZAS domain comprised of two widely separated regions of zinc finger motifs, a stretch of highly acidic Amino acids and a serine/threonine-rich sequence. [provided by RefSeq, Nov 2012]

HIVEP2 Products (1)

mRNA Protein Name
NM_006734.4 NP_006725.3 transcription factor HIVEP2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20936779 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HIVEP2 Protein Structure

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (204 - 228)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (1814 - 1838)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2446 a.a.
Protein Preferred Names Protein Names

transcription factor HIVEP2

  • MHC binding protein-2

HIVEP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HIVEP2 P31629 YWHAG Homo sapiens P61981
Y2H Pooling
20936779
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Intellectual Developmental Disorder, Autosomal Dominant 43

  • MRD43

  • Autosomal Dominant Non-Syndromic Intellectual Disability 43

  • Autosomal Dominant Intellectual Developmental Disorder 43

  • Autosomal Dominant Mental Retardation 43
Hivep2-Related Intellectual Disability

  • Mental Retardation, Autosomal Dominant 43

  • Intellectual Disability, Autosomal Dominant 43

  • Autosomal Dominant Intellectual Disability-43

  • Mrd43
Autosomal Dominant Non-Syndromic Intellectual Disability
Human Immunodeficiency Virus Type 1

  • Aids

  • Hiv/Aids

  • Aids, Delayed/Rapid Progression To

  • Hiv-1, Susceptibility To

  • Hiv-1 Viremia, Susceptibility To

  • Human Immunodeficiency Virus Type 1, Susceptibility To

  • Hiv-1

  • Aids, Slow Progression To

  • Rapid Progression To Aids From Hiv1 Infection

  • Hiv1 Infection, Resistance To

  • Hiv1 Infection

  • Hiv-1 Viremia

  • Aids, Resistance To

  • Aids, Rapid Progression To

  • Hiv/Aids, Susceptibility To

  • Hiv-1, Resistance To

  • Hiv1, Resistance To

  • Hiv1

  • Hiv-1 Disease, Delayed Progression Of

  • Hiv-1 Disease, Rapid Progression Of

  • Hiv Infection, Resistance To

  • Hiv Type 1, Susceptibility To

  • Hiv Type 1

  • Hiv-1 Infection

  • Human Immunodeficiency Virus I Infection

  • Acquired Immunodeficiency Syndrome

  • Hiv-Infection/Aids
Schizophrenia 12

  • Sczd12

  • Schizophrenia Susceptibility Locus, Chromosome 1p-Related
Macular Dystrophy, Patterned, 2

  • Patterned Macular Dystrophy 2

  • MDPT2

  • Macular Dystrophy, Butterfly-Shaped Pigmentary, 2

  • Butterfly-Shaped Pigmentary Maculary Dystrophy 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06188 HIVEP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus HIVEP2 VGNC VGNC:96548
Macaca mulatta HIVEP2 VGNC VGNC:83427
Rattus norvegicus HIVEP2 RGD RGD:61988
Bos taurus HIVEP2 VGNC VGNC:96543
Canis familiaris HIVEP2 VGNC VGNC:81688
Mus musculus HIVEP2 MGD MGI:1338076
Others HIVEP2 NCBI