GNA14 - G protein subunit alpha 14 Gene

Also Known as HG1I

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9630

About GNA14

Cytogenetic location: 9q21.2 Genomic coordinates (GRCh38): 9:77,423,079-77,648,322 (from NCBI)

This gene has 2 transcripts (splice variants), 244 orthologues, 15 paralogues and is associated with 3 phenotypes. Broad expression in thyroid (RPKM 10.6), endometrium (RPKM 6.0) and 22 other tissues.

Summary

This gene encodes a member of the guanine nucleotide-binding, or G protein family. G proteins are heterotrimers consisting of alpha, beta and gamma subunits. The encoded protein is a member of the alpha family of G proteins, more specifically the alpha q subfamily of G proteins. The encoded protein may play a role in pertussis-toxin resistant activation of Phospholipase C-beta and its downstream effectors.[provided by RefSeq, Feb 2009]

GNA14 Products (1)

mRNA Protein Name
NM_004297.4 NP_004288.1 guanine nucleotide-binding protein subunit alpha-14

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNA14 Protein Structure

G-alpha

G-alpha: G-protein alpha subunit (8 - 344)

  • 0
  • 100
  • 200
  • 300
  • 355 a.a.
Protein Preferred Names Protein Names

guanine nucleotide-binding protein subunit alpha-14

  • g alpha-14

GNA14 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GNA14 O95837 DNAL4 Homo sapiens O96015
Y2H Prey Pooling
25416956
Intra
GNA14 O95837 SETDB1 Homo sapiens Q15047-2
Validated Y2H
32814053
Intra
GNA14 O95837 SETDB1 Homo sapiens Q15047-2
Y2H Array
32814053
Intra
GNA14 O95837 SETDB1 Homo sapiens Q15047-2
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Kaposiform Hemangioendothelioma

  • Congenital Cutaneous Multifocal Kaposiform Hemangioendothelioma

  • Kh

  • Khe

  • Kaposiform Hemangio-Endothelioma
Angioma, Tufted

  • Tufted Angioma

  • Angioma Tufted

  • Nakagawa Angioblastoma

  • Tufted Angioma Of Skin
Pyogenic Granuloma

  • Lobular Capillary Hemangioma

  • Granuloma Pyogenic

  • Granuloma Pyogenicum

  • Granuloma Telangiectaticum Of Skin

  • Pyogenic Granuloma Of Skin

  • Lobular Capillary Haemangioma Of Skin
Pertussis

  • Whooping Cough

  • Bordetella Infections

  • Bordetella Infection

  • Bordetella Pertussis Infection

  • Wc - Whooping Cough

  • Whooping Cough Due To Unspecified Organism

  • Bordetellosis

  • Tussis Convulsiva

  • Whooping Cough, Unspecified Organism

  • Wc - [Whooping Cough]

  • Whooping Cough Due To B. Parapertussis

  • Infection Due To Bordetella Parapertussis
Rapidly Involuting Congenital Hemangioma

  • Rich
Hyperinsulinemic Hypoglycemia, Familial, 5

  • Hyperinsulinism Due To Insr Deficiency

  • HHF5

  • Familial Hyperinsulinemic Hypoglycemia 5

  • Hyperinsulinemic Hypoglycemia Due To Insr Deficiency

  • Hyperinsulinemic Hypoglycemia Due To Insulin Receptor Deficiency

  • Congenital Hyperinsulinism

  • Persistent Hyperinsulinemic Hypoglycemia Of Infancy

  • Phhi

  • Hyperinsulinemic Hypoglycemia Familial 5
Spindle Cell Hemangioma

  • Sch

  • Spindle Cell Hemangioendothelioma
Sturge-Weber Syndrome

  • SWS

  • Encephalotrigeminal Angiomatosis

  • Encephalofacial Angiomatosis

  • Sturge-Weber-Dimitri Syndrome

  • Sturge-Weber-Krabbe Syndrome

  • Fourth Phacomatosis

  • Leptomeningeal Angiomatosis

  • Meningeal Capillary Angiomatosis

  • Sturge-Weber-Krabbe Angiomatosis

  • Sturge-Weber Syndrome, Somatic, Mosaic

  • Sws Type I - Facial And Leptomeningeal Angiomas

  • Sws Type Ii - Facial Angioma Alone, No Cns Involvement

  • Sws Type Iii - Isolated Leptomeningeal Angiomas

  • Sturge Weber Syndrome

  • Angiomatosis Aculoorbital-Thalamic Syndrome

  • Encephalofacial Hemangiomatosis

  • Encephalofacial Hemangiomatosis Syndrome

  • Meningo-Oculo-Facial Angiomatosis

  • Meningofacial Angiomatosis-Cerebral Calcification Syndrome

  • Neuroretinoangiomatosis

  • Phakomatosis, Sturge-Weber

  • Weber-Sturge-Dimitri Syndrome
Hemangioma

  • Hemangiomas
Multiple Enchondromatosis, Maffucci Type

  • Maffucci Syndrome

  • Chondrodysplasia With Hemangioma

  • Chondroplasia Angiomatosis

  • Enchondromatosis With Hemangiomata

  • Hemangiomatosis Chondrodystrophica

  • Kast Syndrome

  • Multiple Angiomas And Endochondromas

  • Dyschondrodysplasia With Hemangiomas

  • Enchondromatosis Type Ii

  • Enchondromatosis With Multiple Cavernous Hemangiomas

  • Dyschondroplasia And Cavernous Hemangioma

  • Hemangiomata With Dyschondroplasia
Capillary Hemangioma

  • Infantile Hemangioma

  • Strawberry Nevus Of Skin

  • Cellular Hemangioma Of Infancy

  • Congenital Vascular Hamartoma

  • Congenital Vascular Naevus

  • Juvenile Hemangioma

  • Strawberry Haemangioma

  • Strawberry Nevus

  • Hemangioma Capillary

  • Hemangioma, Capillary

  • Hemangioma, Cavernous
Klippel-Trenaunay-Weber Syndrome

  • Klippel-Trenaunay Syndrome

  • KTS

  • Ktw Syndrome

  • Angioosteohypertrophy Syndrome

  • Angio-Osteohypertrophy Syndrome

  • Klippel Trenaunay Syndrome

  • Klippel-Trénaunay-Weber Syndrome

  • Haemangiectatic Hypertrophy

  • Weber-Klippel-Trenaunay

  • Congenital Dysplastic Angiopathy

  • Klippel-Trenaunay Disease

  • Weber Klippel Trenaunay
Proteus Syndrome

  • Proteus Syndrome, Somatic

  • Partial Gigantism-Nevi-Hemihypertrophy-Macrocephaly Syndrome

  • Gigantism, Partial, Of Hands And Feet, Nevi, Hemihypertrophy, And Macrocephaly

  • Wiedemann'S Syndrome

  • Hemihypertrophy And Macrocephaly

  • Partial Gigantism Of Hands And Feet, Nevi, Hemihypertrophy, Macrocephaly

  • Ps

  • PROTEUSS

  • Partial Gigantism Of Hands And Feet Nevi Hemihypertrophy And Macrocephaly
Cavernous Hemangioma

  • Hemangioma, Cavernous

  • Cavernoma

  • Cavernous Haemangioma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05532 GNA14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19685 Gna14 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26178 Gna14 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GNA14 VGNC VGNC:102934
Macaca mulatta GNA14 VGNC VGNC:73088
Canis familiaris GNA14 VGNC VGNC:41299
Bos taurus GNA14 VGNC VGNC:29447
Mus musculus GNA14 MGD MGI:95769
Rattus norvegicus GNA14 RGD RGD:1308122
Others GNA14 NCBI