RAF1 - Raf-1 proto-oncogene, serine/threonine kinase Gene

Also Known as NS5; CRAF; Raf-1; c-Raf; CMD1NN

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5894

About RAF1

Cytogenetic location: 3p25.2 Genomic coordinates (GRCh38): 3:12,583,601-12,664,117 (from NCBI)

This gene has 74 transcripts (splice variants), 221 orthologues, 23 paralogues and is associated with 85 phenotypes. Ubiquitous expression in bone marrow (RPKM 34.4), heart (RPKM 32.5) and 25 other tissues.

Summary

This gene is the cellular homolog of viral Raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, Apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]

RAF1 Products (16)

mRNA	Protein	Name
NM_001354693.3	NP_001341622.1	RAF proto-oncogene serine/threonine-protein kinase isoform d
NM_001354695.3	NP_001341624.1	RAF proto-oncogene serine/threonine-protein kinase isoform f
NM_001354689.3	NP_001341618.1	RAF proto-oncogene serine/threonine-protein kinase isoform a
NM_001354690.3	NP_001341619.1	RAF proto-oncogene serine/threonine-protein kinase isoform b
NM_002880.4	NP_002871.1	RAF proto-oncogene serine/threonine-protein kinase isoform b
XM_047448651.1	XP_047304607.1	RAF proto-oncogene serine/threonine-protein kinase isoform X2
NM_001354691.3	NP_001341620.1	RAF proto-oncogene serine/threonine-protein kinase isoform c
NR_148941.3
XM_011533974.3	XP_011532276.1	RAF proto-oncogene serine/threonine-protein kinase isoform X1
NM_001354694.3	NP_001341623.1	RAF proto-oncogene serine/threonine-protein kinase isoform e
XM_017006966.1	XP_016862455.1	RAF proto-oncogene serine/threonine-protein kinase isoform X2
NR_148942.3
NR_148940.3
XM_047448649.1	XP_047304605.1	RAF proto-oncogene serine/threonine-protein kinase isoform X1
XM_047448650.1	XP_047304606.1	RAF proto-oncogene serine/threonine-protein kinase isoform X1
NM_001354692.3	NP_001341621.1	RAF proto-oncogene serine/threonine-protein kinase isoform c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	23509299	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	17979178	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7644510	GOA
enables protein kinase activity	EXP EXP: Inferred from Experiment	9446616	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	19667065	GOA
NOT enables small GTPase binding	IPI IPI: Inferred from physical interaction	12194967	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in activation of adenylate cyclase activity	IDA IDA: Inferred from direct assay	15385642	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	19667065	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	9765203	GOA
involved in negative regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	19667065	GOA
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	10644344	GOA
involved in positive regulation of peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	19667065	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IPI IPI: Inferred from physical interaction	17724343	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17724343	GOA
located in cytosol	IDA IDA: Inferred from direct assay	16009725	GOA
colocalizes with plasma membrane	IDA IDA: Inferred from direct assay	16009725	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	17724343	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAF1 Protein Structure

RBD

C1_1

Pkinase_Tyr

0
100
200
300
400
500
600
648 a.a.

Protein Preferred Names	Protein Names
RAF proto-oncogene serine/threonine-protein kinase	C-Raf proto-oncogene, serine/threonine kinase Oncogene RAF1 proto-oncogene c-RAF raf proto-oncogene serine/threonine protein kinase v-raf-1 murine leukemia viral oncogene homolog 1 v-raf-1 murine leukemia viral oncogene-like protein 1

RAF1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RAF1	P04049	PAK2	Homo sapiens	Q13177	Protein Kinase Assay	16837009
Intra	RAF1	P04049	PAK2	Homo sapiens	Q13177	NMR	16837009
Intra	RAF1	P04049	MLF2	Homo sapiens	Q15773	Anti Tag CoIP	37045861
Intra	RAF1	P04049	MAP2K2	Homo sapiens	P36507	Y2H	21988832
Intra	RAF1	P04049	PPP2R5C	Homo sapiens	Q13362	Phosphatase Assay	16239230
Intra	RAF1	P04049	PPP2R5C	Homo sapiens	Q13362	Anti Tag CoIP	16239230
Cross	RAF1	P04049	RAS2	Saccharomyces cerevisiae	P01120	Pull Down	21457714
Intra	RAF1	P04049	RCAN1	Homo sapiens	P53805-2	Pull Down	15935327
Intra	RAF1	P04049	PAQR3	Homo sapiens	Q6TCH7	Anti Tag CoIP	17724343
Intra	RAF1	P04049	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	37045861
Intra	RAF1	P04049	CDC37	Homo sapiens	Q16543	Pull Down	32707033
Intra	RAF1	P04049	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	31980649
Intra	RAF1	P04049	CDC37	Homo sapiens	Q16543	TAP	17979178
Intra	RAF1	P04049	HSP90AA1	Homo sapiens	P07900	Pull Down	32707033
Intra	RAF1	P04049	HSP90AA1	Homo sapiens	P07900	Anti Tag CoIP	31980649
Intra	RAF1	P04049	HSP90AA1	Homo sapiens	P07900	Anti Tag CoIP	37045861
Intra	RAF1	P04049	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	37045861
Intra	RAF1	P04049	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	31980649
Intra	RAF1	P04049	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	25852190
Intra	RAF1	P04049	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	26496610
Intra	RAF1	P04049	YWHAH	Homo sapiens	Q04917	TAP	17979178
Intra	RAF1	P04049	YWHAH	Homo sapiens	Q04917	Pull Down	32707033
Intra	RAF1	P04049	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	37045861
Intra	RAF1	P04049	YWHAZ	Homo sapiens	P63104	Peptide Array	8601312
Intra	RAF1	P04049	YWHAZ	Homo sapiens	P63104	Y2H	8085158
Intra	RAF1	P04049	YWHAZ	Homo sapiens	P63104	Pull Down	7939632
Intra	RAF1	P04049	YWHAZ	Homo sapiens	P63104	Pull Down	10887173
Intra	RAF1	P04049	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	31980649
Intra	RAF1	P04049	YWHAZ	Homo sapiens	P63104	TAP	17979178
Intra	RAF1	P04049	YWHAZ	Homo sapiens	P63104	Biochemical	11697890
Intra	RAF1	P04049	YWHAZ	Homo sapiens	P63104	Pull Down	32707033
Intra	RAF1	P04049	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	35271311
Intra	RAF1	P04049	YWHAZ	Homo sapiens	P63104	Pull Down	16306228
Intra	RAF1	P04049	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	25852190
Intra	RAF1	P04049	YWHAZ	Homo sapiens	P63104	CoIP	20052757
Intra	RAF1	P04049	HRAS	Homo sapiens	P01112	FRET	18273062
Intra	RAF1	P04049	HRAS	Homo sapiens	P01112	GMS	18073111
Intra	RAF1	P04049	HRAS	Homo sapiens	P01112	Anti Tag CoIP	19063885
Intra	RAF1	P04049	HRAS	Homo sapiens	P01112	Y2H	12620389
Intra	RAF1	P04049	HRAS	Homo sapiens	P01112	Y2H	19696784
Intra	RAF1	P04049	HRAS	Homo sapiens	P01112	Pull Down	20178605
Intra	RAF1	P04049	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	31980649
Intra	RAF1	P04049	HSP90AB1	Homo sapiens	P08238	TAP	17979178
Intra	RAF1	P04049	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	RAF1	P04049	HSP90AB1	Homo sapiens	P08238	Pull Down	32707033
Intra	RAF1	P04049	HSP90AB1	Homo sapiens	P08238	Anti Bait CoIP	16330544
Intra	RAF1	P04049	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	37045861
Intra	RAF1	P04049	PKM	Homo sapiens	P14618	Y2H	12620389
Intra	RAF1	P04049	HSPA5	Homo sapiens	P11021	Anti Bait CoIP	18064632
Intra	RAF1	P04049	TIMM50	Homo sapiens	Q3ZCQ8	Anti Tag CoIP	31980649
Intra	RAF1	P04049	TIMM50	Homo sapiens	Q3ZCQ8	Anti Tag CoIP	37045861
Intra	RAF1	P04049	TIMM50	Homo sapiens	Q3ZCQ8	Anti Tag CoIP	25852190
Intra	RAF1	P04049	TIMM50	Homo sapiens	Q3ZCQ8	Y2H	12620389
Intra	RAF1	P04049	BAG2	Homo sapiens	O95816	Anti Tag CoIP	37045861
Intra	RAF1	P04049	BAG2	Homo sapiens	O95816	Lumier	25036637
Intra	RAF1	P04049	BAG2	Homo sapiens	O95816	Anti Tag CoIP	31980649
Intra	RAF1	P04049	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	31980649
Intra	RAF1	P04049	YWHAE	Homo sapiens	P62258	Pull Down	32707033
Intra	RAF1	P04049	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	35271311
Intra	RAF1	P04049	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	37045861
Intra	RAF1	P04049	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	25852190
Intra	RAF1	P04049	CCT3	Homo sapiens	P49368	Anti Tag CoIP	37045861
Intra	RAF1	P04049	CCT3	Homo sapiens	P49368	Y2H	12620389
Intra	RAF1	P04049	CCT3	Homo sapiens	P49368	Anti Tag CoIP	31980649
Intra	RAF1	P04049	STUB1	Homo sapiens	Q9UNE7	Anti Tag CoIP	37045861
Intra	RAF1	P04049	YWHAB	Homo sapiens	P31946	Anti Tag CoIP	31980649
Intra	RAF1	P04049	YWHAB	Homo sapiens	P31946	Pull Down	32707033
Intra	RAF1	P04049	YWHAB	Homo sapiens	P31946	Anti Tag CoIP	37045861
Intra	RAF1	P04049	YWHAB	Homo sapiens	P31946	Anti Tag CoIP	35271311
Intra	RAF1	P04049	YWHAB	Homo sapiens	P31946	Y2H	12620389
Intra	RAF1	P04049	YWHAB	Homo sapiens	P31946	Anti Bait CoIP	7644510
Intra	RAF1	P04049	YWHAB	Homo sapiens	P31946	Anti Tag CoIP	25852190
Intra	RAF1	P04049	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	31980649
Intra	RAF1	P04049	YWHAG	Homo sapiens	P61981	Biochemical	11697890
Intra	RAF1	P04049	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	25852190
Intra	RAF1	P04049	YWHAG	Homo sapiens	P61981	Pull Down	32707033
Intra	RAF1	P04049	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	37045861
Intra	RAF1	P04049	YWHAQ	Homo sapiens	P27348	Anti Tag CoIP	31980649
Intra	RAF1	P04049	YWHAQ	Homo sapiens	P27348	Pull Down	32707033
Intra	RAF1	P04049	YWHAQ	Homo sapiens	P27348	Pull Down	7760835
Intra	RAF1	P04049	YWHAQ	Homo sapiens	P27348	Biochemical	11697890
Intra	RAF1	P04049	YWHAQ	Homo sapiens	P27348	Anti Tag CoIP	25852190
Intra	RAF1	P04049	YWHAQ	Homo sapiens	P27348	Anti Tag CoIP	37045861
Intra	RAF1	P04049	KRAS	Homo sapiens	P01116	Anti Tag CoIP	31980649
Intra	RAF1	P04049	KRAS	Homo sapiens	P01116	Anti Tag CoIP	25852190
Intra	RAF1	P04049	KRAS	Homo sapiens	P01116-2	Pull Down	20802526
Intra	RAF1	P04049	KRAS	Homo sapiens	P01116-2	FRET	20080631
Intra	RAF1	P04049	KRAS	Homo sapiens	P01116-2	Anti Tag CoIP	20802526
Intra	RAF1	P04049	SFN	Homo sapiens	P31947	Anti Tag CoIP	25852190
Intra	RAF1	P04049	SFN	Homo sapiens	P31947	Anti Tag CoIP	31980649
Intra	RAF1	P04049	KSR1	Homo sapiens	Q8IVT5	Anti Tag CoIP	37045861
Intra	RAF1	P04049	KSR1	Homo sapiens	Q8IVT5	Anti Bait CoIP	24929361
Intra	RAF1	P04049	RB1	Homo sapiens	P06400	Anti Bait CoIP	21139044
Intra	RAF1	P04049	RAP1A	Homo sapiens	P62834	X-Ray Diffraction	7791872
Intra	RAF1	P04049	NFATC3	Homo sapiens	Q12968	Anti Bait CoIP	24330068
Intra	RAF1	P04049	CPS1	Homo sapiens	P31327	Y2H	12620389
Intra	RAF1	P04049	OIP5	Homo sapiens	O43482	Y2H	12620389
Cross	RAF1	P04049	Lox	Mus musculus	P28301	Pull Down	21536655
Cross	RAF1	P04049	Kras	Mus musculus	P32883	Pull Down	19164755
Cross	RAF1	P04049	NS5A	Hepacivirus hominis	O39474	Anti Bait CoIP	16405965
Intra	RAF1	P04049	PIN1	Homo sapiens	Q13526	Anti Tag CoIP	20179161
Intra	RAF1	P04049	PEBP1	Homo sapiens	P30086	Anti Bait CoIP	17097642
Intra	RAF1	P04049	PEBP1	Homo sapiens	P30086	Peptide Array	17097642
Intra	RAF1	P04049	PEBP1	Homo sapiens	P30086	SPR	17097642
Intra	RAF1	P04049	PEBP1	Homo sapiens	P30086	Anti Tag CoIP	17097642
Intra	RAF1	P04049	NRAS	Homo sapiens	P01111	Y2H Prey Pooling	32296183
Intra	RAF1	P04049	NRAS	Homo sapiens	P01111	Pull Down	18641128
Intra	RAF1	P04049	NRAS	Homo sapiens	P01111	Anti Tag CoIP	31980649
Intra	RAF1	P04049	NRAS	Homo sapiens	P01111	FRET	20080631
Intra	RAF1	P04049	NRAS	Homo sapiens	P01111	Y2H Array	32296183
Intra	RAF1	P04049	CDC25A	Homo sapiens	P30304	Anti Bait CoIP	7644510
Intra	RAF1	P04049	APP	Homo sapiens	P05067	Validated Y2H	32814053
Intra	RAF1	P04049	APP	Homo sapiens	P05067	Y2H Array	32814053
Intra	RAF1	P04049	APP	Homo sapiens	P05067	Y2H Pooling	32814053
Intra	RAF1	P04049	CASP8	Homo sapiens	Q14790	Y2H Pooling	32814053
Intra	RAF1	P04049	CASP8	Homo sapiens	Q14790	Validated Y2H	32814053
Intra	RAF1	P04049	CASP8	Homo sapiens	Q14790	Y2H Array	32814053
Intra	RAF1	P04049	PEBP4	Homo sapiens	Q96S96	Pull Down	19197339
Intra	RAF1	P04049	STK3	Homo sapiens	Q13188	Pull Down	24929361
Intra	RAF1	P04049	STK3	Homo sapiens	Q13188	Peptide Array	24929361
Intra	RAF1	P04049	STK3	Homo sapiens	Q13188	Anti Tag CoIP	24929361
Intra	RAF1	P04049	STK3	Homo sapiens	Q13188	Anti Bait CoIP	24929361

Cross: Cross-species interaction Intra: Intraspecies interaction

RAF1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80880	Raf-1 Antibody (YA107)	WB, ICC/IF	Human, Mouse, Rat
HY-P80880A	Raf-1 Antibody (YA107)(PBS only)	WB, ICC/IF	Human, Mouse, Rat
HY-P810661	Phospho-Raf1 (Ser259) Antibody (YA9921)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
HY-P810662	Phospho-Raf1 (Ser43) Antibody (YA9922)	WB	Human, Mouse, Rat
HY-P810663	Phospho-Raf1 (Ser621) Antibody (YA9923)	WB, IHC-P	Human, Mouse, Rat
HY-P86172	Raf-1 Antibody (YA5864)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Cardiofaciocutaneous Syndrome 1	Cardiofaciocutaneous Syndrome Cfc Syndrome Cardio-Facio-Cutaneous Syndrome CFC1 Cfcs Cardio-Facial-Cutaneous Syndrome Congenital Heart Defects Characteristic Facial Appearance Ectodermal Abnormalities And Growth Failure Cardiofaciocutaneous Syndrome, Type 1
Cholangiocarcinoma	Cholangiocarcinoma, Susceptibility To Extrahepatic Cholangiocarcinoma Intrahepatic Cholangiocarcinoma Chlc Chlc, Susceptibility To Cc Cholangiocarcinoma Of Biliary Tract Cholangiocellular Carcinoma Distal Cholangiocarcinoma Perihilar Cholangiocarcinoma Bile Duct Cancer Cca Adult Primary Cholangiocellular Carcinoma Bile Duct Carcinoma
Pancreatic Adenocarcinoma	Adenocarcinoma Of Pancreas Adenocarcinoma Of The Pancreas Pancreas Adenocarcinoma Malignant Exocrine Neoplasm Primary Pancreatic Adenocarcinoma Adenocarcinoma Of Islet Cell Of Pancreas Islet Cell Adenocarcinoma Of Unspecified Site Mixed Adenocarcinoma Islet Cell With Exocrine Of Unspecified Site
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Thyroid Carcinoma, Familial Medullary	Medullary Thyroid Carcinoma Familial Medullary Thyroid Carcinoma MTC Fmtc Mtc1 Thyroid Cancer, Medullary Medullary Thyroid Cancer Thyroid Carcinoma, Medullary Familial Mtc Thyroid Carcinoma Medullary Carcinoma, Thyroid, Medullary, Familial Medullary Carcinoma Of Thyroid Medullary Carcinoma With Amyloid Stroma, Unspecified Site Medullary Carcinoma With Amyloid Stroma Of Thyroid
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Retinitis Pigmentosa 74	RP74 Retinitis Pigmentosa, Type 74
Familial Isolated Dilated Cardiomyopathy	Familial Or Idiopathic Dilated Cardiomyopathy
Gastric Adenocarcinoma	Adenocarcinoma Of Stomach Stomach Adenocarcinoma Adenocarcinoma Gastric Intestinal Type Adenocarcinoma Of Unspecified Site Diffuse Type Adenocarcinoma Of Unspecified Site
Hepatitis B	Chronic Hepatitis B Hepatitis B Infection Serum Hepatitis HBV Hepatitis B Chronic Hbv, Susceptibility To Hepatitis B, Chronic Chronic Hepatitis B Without Delta Agent Chronic Hbv - [Hepatitis B Virus] Infection Hepatitis B Nos Chronic Type B Viral Hepatitis Hep B Nos
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Noonan Syndrome With Multiple Lentigines	Leopard Syndrome Multiple Lentigines Syndrome Moynahan Syndrome Cardiomyopathic Lentiginosis Progressive Cardiomyopathic Lentiginosis Cardio-Cutaneous Syndrome Lentiginosis Profusa Capute-Rimoin-Konigsmark-Esterly-Richardson Syndrome Generalized Lentiginosis Gorlin Syndrome Ii Lentiginosis Profusa Syndrome Lentigines, Electrocardiographic Conduction Abnormalities, Ocular Hypertelorism, Pulmonic Stenosis, Abnormal Genitalia, Retardation Of Growth, Deafnes Diffuse Lentiginosis Nsml Familial Multiple Lentigines Syndrome Alopecia-Epilepsy-Intellectual Disability Syndrome, Moynahan Type Progressive Cardiomyopathic Lentiginosis Syndrome Alopecia Epilepsy Oligophrenia Syndrome Of Moynahan
Noonan Syndrome 5	NS5 Noonan Syndrome, Type 5
Pilocytic Astrocytoma	Juvenile Pilocytic Astrocytoma Grade I Astrocytic Tumor Piloid Astrocytoma
Leopard Syndrome 2	LPRD2 Noonan Syndrome With Multiple Lentigines 2 Leopard Syndrome, Type 2
Cardiomyopathy, Familial Hypertrophic, 1	Asymmetric Septal Hypertrophy Familial Hypertrophic Cardiomyopathy Hypertrophic Cardiomyopathy 1 CMH1 Hypertrophic Cardiomyopathy 19 CMH Ventricular Hypertrophy, Hereditary Ash Hypertrophic Subaortic Stenosis, Idiopathic Cardiomyopathy, Familial Hypertrophic Cardiomyopathy, Hypertrophic, 1, Digenic Cardiomyopathy, Familial Hypertrophic 1 Hcm Hereditary Ventricular Hypertrophy Hypertrophic Cardiomyopathy Cardiomyopathy, Hypertrophic, 1 Familial Asymmetric Septal Hypertrophy Heritable Hypertrophic Cardiomyopathy Idiopathic Hypertrophic Subaortic Stenosis Fhc Cardiomyopathy, Hypertrophic, Familial, Type 1 Cardiomyopathy, Hypertrophic, Familial
Cardiomyopathy, Dilated, 1nn	CMD1NN Dilated Cardiomyopathy 1nn Cardiomyopathy, Dilated 1nn Cardiomyopathy, Dilated, Type 1nn
Noonan Syndrome And Noonan-Related Syndrome
Lung Adenoma	Adenoma Of Lung Pulmonary Adenoma
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Chlamydia	Chlamydial Infection Chlamydia Trachomatis Infectious Disease Chlamydial Disease Chlamydia Infections
Melanoma, Cutaneous Malignant 1	Familial Melanoma Melanoma, Cutaneous Malignant, Susceptibility To, 1 CMM1 Melanoma, Cutaneous Malignant Cmm Melanoma, Malignant Familial Atypical Mole-Malignant Melanoma Syndrome Fammm Melanoma, Familial Mlm Dysplastic Nevus Syndrome, Hereditary Dns B-K Mole Syndrome Melanoma, Cutaneous Malignant, 1 Malignant Melanoma, Cutaneous Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1 Dysplastic Nevus Syndrome Cutaneous Melanoma Familial Atypical Mole Melanoma Syndrome Hereditary Melanoma
Neuroendocrine Tumor	Neuroendocrine Neoplasm Neuroendocrine Tumors Carcinoma, Neuroendocrine
Neurofibromatosis, Type I	Von Recklinghausen Disease Neurofibromatosis 1 Neurofibromatosis, Type 1 NF1 Neurofibromatosis, Peripheral Type Neurofibromatosis Type I Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion Familial Spinal Neurofibromatosis Fsnf Peripheral Neurofibromatosis Von Recklinghausen'S Neurofibromatosis Von Recklinghausen Disease Due To Nf1 Mutation Or Intragenic Deletion Neurofibromatosis Peripheral Type Von Recklinghausen Syndrome Neurofibromatosis Type 1 Von Recklinghausen Neuropathy Nf1 - [Neurofibromatosis Type 1] Recklinghausen Disease
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Adenoid Cystic Carcinoma	Adenocystic Carcinoma Cribriform Carcinoma Cylindroma Carcinoma Adenoid Cystic Carcinoma, Adenoid Cystic Adenoid Cystic Carcinoma Of Salivary Gland Eccrine Dermal Cylindroma Carcinoma, Cribriform
Hepatitis	Chronic Hepatitis Chronic Persistent Hepatitis Acute Hepatitis Hepatitis, Chronic Acute And Subacute Liver Necrosis Acute/Subac. Necrosis Of Liver Animal Hepatitis Hepatitis Chronic Hepatitis A Hepatitis, Animal Hepatitis Due To Toxoplasmosis Hepatitis In Toxoplasmosis Toxoplasmal Hepatitis Chronic Hepatitis, Unspecified Chronic Active Hepatitis Nec Other Specified Chronic Hepatitis Chronic Persistent Hepatitis Nec Chronic Lobular Hepatitis Nec
Leukemia	Leukemias Leukaemia, Unspecified, Without Mention Of Remission Aleukemic Leukaemia Chronic Leukaemia Subacute Leukaemia Leukaemia Disorder Leukaemia Nos
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Pulmonic Stenosis	Congenital Pulmonary Valvar Stenosis Congenital Stenosis Of Pulmonary Valve Valvular Pulmonic Stenosis Pulmonary Valve Stenosis Pulmonary Stenosis Congenital Pulmonary Valve Stricture Congenital Pulmonary Valve Stenosis
Noonan Syndrome 1	Noonan Syndrome NS1 Male Turner Syndrome Female Pseudo-Turner Syndrome Turner Phenotype With Normal Karyotype Noonan Syndrome With Pigmented Villonodular Synovitis Turner'S Phenotype, Karyotype Normal Familial Turner Syndrome Noonan'S Syndrome Noonan-Ehmke Syndrome Ns Pseudo-Ullrich-Turner Syndrome Turner Syndrome In Female With X Chromosome Turner-Like Syndrome Ullrich-Noonan Syndrome Noonan-Like/Multiple Giant Cell Lesion Syndrome Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions Pterygium Colli Syndrome Noonan Syndrome, Type 1 Turner Syndrome, Male
Lentigines	Lentigo
Gastrointestinal Stromal Tumor	GIST Gastrointestinal Stromal Tumors Gastrointestinal Stromal Sarcoma Gastrointestinal Stromal Tumor, Familial Gant Gastrointestinal Stromal Tumour Stromal Tumor Of Gastrointestinal Tract Stromal Tumour Of Gastrointestinal Tract Gastrointestinal Stromal Neoplasm Paraganglioma And Gastric Stromal Sarcoma Plexosarcoma
Noonan Syndrome 3	NS3 Noonan Syndrome, Type 3
Hypertrophic Cardiomyopathy	Hypertrophic Obstructive Cardiomyopathy Cardiomyopathy, Hypertrophic Cardiomyopathy, Hypertrophic, Familial Familial Hypertrophic Cardiomyopathy Cardiomyopathy Hypertrophic Obstructive Idiopathic Myocardial Hypertrophy Idiopathic Hypertrophic Cardiomyopathy Obstructive Idiopathic Hypertrophic Cardiomyopathy Obstructive Cardiomyopathy Idiopathic Hypertrophic Subaortic Stenosis Muscular Subaortic Stenosis Hypertrophic Obstructive Subaortic Stenosis
Juvenile Myelomonocytic Leukemia	Leukemia, Juvenile Myelomonocytic JMML Leukemia, Juvenile Myelomonocytic, Somatic Juvenile Chronic Myelomonocytic Leukemia Juvenile Chronic Myelogenous Leukemia Leukemia, Myelomonocytic, Juvenile Juvenile Myelomonocytic Leukaemia Without Mention Of Remission
Rasopathy	Ras/Mitogen-Activated Protein Kinase Syndrome
Melanoma In Congenital Melanocytic Nevus	Malignant Melanoma In Congenital Melanocytic Nevus Melanocytic Nevi Nevi Melanocytic
Erythrocytosis, Familial, 3	ECYT3 Familial Erythrocytosis 3 Erythrocytosis, Familial, Type 3
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Skin Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Skin Epidermoid Skin Carcinoma Squamous Cell Carcinoma Of The Skin Squamous Cell Epithelioma Of Skin Cutaneous Squamous Cell Carcinoma Scc - [Squamous Cell Carcinoma] Of Skin
Respiratory System Benign Neoplasm
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Laryngeal Squamous Cell Carcinoma	Epidermoid Carcinoma Of The Larynx Squamous Cell Carcinoma Of Larynx Squamous Cell Carcinoma Of The Larynx Squamous Cell Carcinoma Of Head And Neck
Pseudo-Turner Syndrome	Noonan Syndrome
Kidney Cancer	Renal Cancer Renal Carcinoma Kidney Neoplasm Malignant Neoplasm Of Kidney Except Pelvis Malignant Tumour Of Kidney Kidney Neoplasms Cancer, Kidney Cancer, Renal Malignant Neoplasm Of Kidney Renal Cell Carcinoma
Skin Melanoma	Cutaneous Melanoma Malignant Ear Melanoma Malignant Lip Melanoma Malignant Lower Limb Melanoma Malignant Melanoma Of Ear And/Or External Auricular Canal Malignant Melanoma Of Skin Of Lower Limb Malignant Melanoma Of Skin Of Trunk Except Scrotum Malignant Melanoma Of Skin Of Upper Limb Malignant Neck Melanoma Malignant Scalp Melanoma Malignant Trunk Melanoma Malignant Upper Limb Melanoma Melanoma, Cutaneous Malignant Melanoma Malignant Melanoma Of Skin Melanoma Nos Malignant Mole, Meaning Melanoma Of Unspecified Site Melanoma Of Unspecified Site Cutaneous Malignant Melanoma Mm - [Malignant Melanoma]
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Costello Syndrome	Faciocutaneoskeletal Syndrome Fcs Syndrome Congenital Myopathy With Excess Of Muscle Spindles CSTLO CMEMS Fcss Myopathy, Congenital, With Excess Of Muscle Spindles
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Pilomyxoid Astrocytoma
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Acneiform Dermatitis	Dermatitis Acneiform

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (9)

Cat. No.	Product Name	Purity	Rare Diseases
HY-12057	Vemurafenib	99.90%	Yes
HY-10331	Regorafenib	99.97%	Yes
HY-10201S	Sorafenib-d3	99.57%	Unkown
HY-10331A	Regorafenib monohydrate	99.94%	Yes
HY-N6670	Cefotetan	99.75%	Unkown
HY-13308	Regorafenib Hydrochloride	99.58%	Yes
HY-10201R	Sorafenib (Standard)	99.71%	Unkown
HY-10331B	Regorafenib mesylate	/	Unkown
HY-10201AR	Sorafenib tosylate (Standard)	/	Unkown

Clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-159127	HRS-4642		99.74%	Phase 2
HY-114491	Rineterkib	Inhibitor	98.79%	Phase 2
HY-114491A	Rineterkib hydrochloride	Inhibitor	99.81%	Phase 2
HY-134813	MRTX1133	Inhibitor	99.97%	Phase 1
HY-51424	PLX-4720	Inhibitor	99.90%	Phase 1
HY-158107	BBO-8520	Inhibitor	99.90%	Phase 1

Pre-clinical Phase

Bioactive Molecules (44)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-11004	AZ 628		99.44%	Unkown
HY-18832	AWL-II-38.3	Inhibitor	99.68%	Unkown
HY-I0678	Regorafénib N-oxyde (M2)		98.15%	Unkown
HY-W013411A	Locostatin		99.88%	Unkown
HY-122914	KRAS inhibitor-3	Inhibitor	99.87%	Unkown
HY-P1039A	R18 TFA		99.36%	Unkown
HY-112440	HZX-02-059	Inhibitor	99.40%	Unkown
HY-123673	MCP110	Inhibitor	99.82%	Unkown
HY-15716	Kobe0065		99.93%	Unkown
HY-115501	(E)-FOBISIN101	Inhibitor	95.63%	Unkown
HY-117737A	RRD-251		99.87%	Unkown
HY-15717	Kobe2602	Inhibitor	98.20%	Unkown
HY-181420A	BBO-11818		99.77%	Unkown
HY-10201S2	Sorafenib-13C,d3		98.35%	Unkown
HY-177511	KRAS G12D-IN-30	Inhibitor	99.38%	Unkown
HY-164365	PROTAC K-Ras Degrader-2	Degrader	/	Unkown
HY-134813A	MRTX1133 formic	Inhibitor	98.23%	Unkown
HY-158107A	(4R)-BBO-8520	Inhibitor	/	Unkown
HY-P1039	R18		/	Unkown
HY-W013411	(E/Z)-Locostatin	Control	99.52%	Unkown
HY-10201S1	Sorafenib-d4		99.9%	Unkown
HY-10201S4	Sorafenib-d3 tosylate	Inhibitor	/	Unkown
HY-10331S1	Regorafenib-13C,d3		/	Unkown
HY-12057S	Vemurafenib-d5		/	Unkown
HY-12057S1	Vemurafenib-d7		/	Unkown
HY-161760	Ferroptosis inducer-3	Inhibitor	/	Unkown
HY-175870A	(7R)-Eras-4001	Inhibitor	/	Unkown
HY-179133	HDB-1	Inhibitor	98.02%	Unkown
HY-181420	(S,R,S)-BBO-11818		/	Unkown
HY-182749	KRAS-IN-58	Inhibitor	/	Unkown
HY-183674	MEK-IN-10		/	Unkown
HY-E70747	MEK5 Recombinant Human Active Protein Kinase		/	Unkown
HY-E70765	RAF1 YDYD Recombinant Human Active Protein Kinase		/	Unkown
HY-I0678S	Regorafénib N-oxyde-d3 (M2)		/	Unkown
HY-I0678S1	Regorafénib N-oxyde (M2)-13C,d3		/	Unkown
HY-N13009	MO-2097		/	Unkown
HY-RS11619	RAF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11620	Raf1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS11621	Raf1 Rat Pre-designed siRNA Set A		/	Unkown
HY-RS12020	RNASE3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W1126467	RAS-IN-5	Inhibitor	/	Unkown
HY-51424S	PLX-4720-d7	Inhibitor	/	Unkown
HY-N15264	Azaspirene	Inhibitor	/	Unkown
HY-RS26697	Rnase2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RAF1	MGD	MGI:97847
Rattus norvegicus	RAF1	RGD	RGD:3531
Felis catus	RAF1	VGNC	VGNC:69220
Canis familiaris	RAF1	VGNC	VGNC:45325
Macaca mulatta	RAF1	VGNC	VGNC:76649
Others	RAF1	NCBI