1. MAPK/ERK Pathway
    Stem Cell/Wnt
  2. Raf
    ERK
  3. Rineterkib hydrochloride

Rineterkib hydrochloride 

Cat. No.: HY-114491A
Handling Instructions

Rineterkib hydrochloride (compound B) is an orally active RAF and ERK1/2 inhibitor in the treatment of a proliferative disease characterized by activating mutations in the MAPK pathway. The activity is particularly related to the treatment of KRAS-mutant NSCLC, BRAF-mutant NSCLC, KRAS-mutant pancreatic cancer, KRAS-mutant colorectal cancer (CRC) and KRAS-mutant ovarian cancer.

For research use only. We do not sell to patients.

Rineterkib hydrochloride Chemical Structure

Rineterkib hydrochloride Chemical Structure

CAS No. : 1715025-34-5

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Description

Rineterkib hydrochloride (compound B) is an orally active RAF and ERK1/2 inhibitor in the treatment of a proliferative disease characterized by activating mutations in the MAPK pathway. The activity is particularly related to the treatment of KRAS-mutant NSCLC, BRAF-mutant NSCLC, KRAS-mutant pancreatic cancer, KRAS-mutant colorectal cancer (CRC) and KRAS-mutant ovarian cancer[1].

In Vivo

ERK-IN-1 (compound B) (50, 75 mg/kg, p.o., qd/q2d, 27 days) treatment significantly reduces the tumor volume in the Calu-6 human NSCLC subcutaneous tumor xenograft model in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Calu-6 NSCLC xenograft tumor models in mice[1].
Dosage: 50, 75 mg/kg.
Administration: Orally either daily (qd) or every other day (q2d) for 27 days.
Result: Significantly reduced the tumor volume.
Formula

C₂₆H₂₇BrF₃N₅O₂.xClH

CAS No.

1715025-34-5

SMILES

O=C(N[[email protected]@H](C1=CC(F)=CC(Br)=C1)CNC)C2=CC=C(C3=NC([[email protected]@H]4C[[email protected]](F)[[email protected]@H](O)CC4)=CN=C3N)C=C2F.[H]Cl.[x]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

RineterkibRafERKRaf kinasesExtracellular signal regulated kinasesNSCLCKRASMAPKG12CG12DG12VInhibitorinhibitorinhibit

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Product Name:
Rineterkib hydrochloride
Cat. No.:
HY-114491A
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