Rineterkib
Based on 1 Customer Validation
Rineterkib (compound B) is an orally available ERK1 and ERK2 inhibitor in the treatment of a proliferative disease characterized by activating mutations in the MAPK pathway. The activity is particularly related to the treatment of KRAS-mutant NSCLC, BRAF-mutant NSCLC, KRAS-mutant pancreatic cancer, KRAS-mutant colorectal cancer (CRC) and KRAS-mutant ovarian cancer. Rineterkib hydrochloride can also inhibit RAF.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.76%
- No. CAS: 1715025-32-3
- Fòrmula: C26H27BrF3N5O2
- Peso molecular:578.42
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Almacenamiento:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
ERK1 |
ERK2 |
RAF |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Calu-6 NSCLC xenograft tumor models in mice[1].
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Dosage:50, 75 mg/kg.
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Administration:Orally either daily (qd) or every other day (q2d) for 27 days.
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Result:Significantly reduced the tumor volume.
Chemical Information
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No. CAS 1715025-32-3
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Appearance Solid
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Peso molecular 578.42
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Fòrmula C26H27BrF3N5O2
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Color White to light yellow
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SMILES
O=C(N[C@@H](C1=CC(F)=CC(Br)=C1)CNC)C2=CC=C(C3=NC([C@@H]4C[C@H](F)[C@@H](O)CC4)=CN=C3N)C=C2F
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvente y solubilidad
In Vitro:
DMSO : 100 mg/mL (172.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7288 mL | 8.6442 mL | 17.2885 mL | 43.2212 mL |
| 5 mM | 0.3458 mL | 1.7288 mL | 3.4577 mL | 8.6442 mL | |
| 10 mM | 0.1729 mL | 0.8644 mL | 1.7288 mL | 4.3221 mL | |
| 15 mM | 0.1153 mL | 0.5763 mL | 1.1526 mL | 2.8814 mL | |
| 20 mM | 0.0864 mL | 0.4322 mL | 0.8644 mL | 2.1611 mL | |
| 25 mM | 0.0692 mL | 0.3458 mL | 0.6915 mL | 1.7288 mL | |
| 30 mM | 0.0576 mL | 0.2881 mL | 0.5763 mL | 1.4407 mL | |
| 40 mM | 0.0432 mL | 0.2161 mL | 0.4322 mL | 1.0805 mL | |
| 50 mM | 0.0346 mL | 0.1729 mL | 0.3458 mL | 0.8644 mL | |
| 60 mM | 0.0288 mL | 0.1441 mL | 0.2881 mL | 0.7204 mL | |
| 80 mM | 0.0216 mL | 0.1081 mL | 0.2161 mL | 0.5403 mL | |
| 100 mM | 0.0173 mL | 0.0864 mL | 0.1729 mL | 0.4322 mL |
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