2. MAPK/ERK Pathway
  3. Raf
  4. R18 TFA

R18 TFA  (Synonyms: PHCVPRDLSWLDLEANMCLP TFA)

Cat. No.: HY-P1039A Purity: 98.35%
COA Handling Instructions

R18 TFA is a peptide antagonists of 14-3-3, with a KD of 70-90 nM. R18 efficiently blocks the binding of 14-3-3 to the kinase Raf-1, a physiological ligand of 14-3-3, and effectively abolished the protective role of 14-3-3 against phosphatase-induced inactivation of Raf-1.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

R18 TFA Chemical Structure

R18 TFA Chemical Structure

Size Price Stock Quantity
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of R18 TFA:

  • R18 Get quote
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BRaf c-Raf Raf

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Description

R18 TFA is a peptide antagonists of 14-3-3, with a KD of 70-90 nM. R18 efficiently blocks the binding of 14-3-3 to the kinase Raf-1, a physiological ligand of 14-3-3, and effectively abolished the protective role of 14-3-3 against phosphatase-induced inactivation of Raf-1[1].

Molecular Weight

2423.73

Appearance

Solid

Formula

C103H158F3N27O31S3
Sequence

Pro-His-Cys-Val-Pro-Arg-Asp-Leu-Ser-Trp-Leu-Asp-Leu-Glu-Ala-Asn-Met-Cys-Leu-Pro
Sequence Shortening

PHCVPRDLSWLDLEANMCLP
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro: 

H2O : ≥ 25 mg/mL (10.31 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4126 mL 2.0629 mL 4.1259 mL
5 mM 0.0825 mL 0.4126 mL 0.8252 mL
10 mM 0.0413 mL 0.2063 mL 0.4126 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 98.35%

COA (242 KB) LCMS (86 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

R18PHCVPRDLSWLDLEANMCLPR 18R-18RafRaf kinasesInhibitorinhibitorinhibit

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