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R18 (Synonyms: PHCVPRDLSWLDLEANMCLP)

Cat. No.: HY-P1039
Handling Instructions

R18 is a peptide antagonists of 14-3-3, with a KD of 70-90 nM. R18 efficiently blocks the binding of 14-3-3 to the kinase Raf-1, a physiological ligand of 14-3-3, and effectively abolished the protective role of 14-3-3 against phosphatase-induced inactivation of Raf-1.

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R18 Chemical Structure

R18 Chemical Structure

CAS No. : 211364-78-2

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Description

R18 is a peptide antagonists of 14-3-3, with a KD of 70-90 nM. R18 efficiently blocks the binding of 14-3-3 to the kinase Raf-1, a physiological ligand of 14-3-3, and effectively abolished the protective role of 14-3-3 against phosphatase-induced inactivation of Raf-1[1].

Molecular Weight

2309.69

Formula

C₁₀₁H₁₅₇N₂₇O₂₉S₃

CAS No.

211364-78-2

Sequence

Pro-His-Cys-Val-Pro-Arg-Asp-Leu-Ser-Trp-Leu-Asp-Leu-Glu-Ala-Asn-Met-Cys-Leu-Pro

Sequence Shortening

PHCVPRDLSWLDLEANMCLP

SMILES

[PHCVPRDLSWLDLEANMCLP]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

R18PHCVPRDLSWLDLEANMCLPR 18R-18OthersInhibitorinhibitorinhibit

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