(Rac)-Zearalanone-d6
(Rac)-Zearalanone-d6 is the d6-labeled (Rac)-Zearalanone (HY-N6678A). (Rac)-Zearalanone is an ATP-competitive HSP90 inhibitor with an EC50 of 2.3 μM. (Rac)-Zearalanone interferes with the binding of ATP to HSP90, impairs the chaperone function of HSP90, and promotes the degradation of client proteins. (Rac)-Zearalanone reduces intracellular accumulation of Raf-1, induces cleavage of caspase-3, and promotes Her2 degradation in a dose-dependent manner by disrupting the Her2-HSP90 interaction. (Rac)-Zearalanone can be used in the research of small cell lung cancer and breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 1795020-90-4
- Formula: C18H18D6O5
- Molecular Weight:326.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1795020-90-4
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Unlabeled Cas 42011-78-9
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Molecular Weight 326.42
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Formula C18H18D6O5
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SMILES
OC1=C2C(=CC(O)=C1)CCCCCC(=O)CCC(C(C([2H])([2H])[2H])(OC2=O)[2H])([2H])[2H]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Zöllner P, et al. Triacsin Concentration levels of zearalenone and its metabolites in urine, muscle tissue, and liversamples of pigs fed with mycotoxin-contaminated oats. J Agric Food Chem. 2002 Apr 24;50(9):2494-501. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(Rac)-Zearalanone-d6 Related Classifications
HY-N6678S Related Classifications
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