(Rac)-Zearalanone
(Rac)-Zearalanone is an ATP-competitive HSP90 inhibitor with an EC50 of 2.3 μM. (Rac)-Zearalanone interferes with the binding of ATP to HSP90, impairs the chaperone function of HSP90, and promotes the degradation of client proteins. (Rac)-Zearalanone reduces intracellular accumulation of Raf-1, induces cleavage of caspase-3, and promotes Her2 degradation in a dose-dependent manner by disrupting the Her2-HSP90 interaction. (Rac)-Zearalanone can be used in the research of small cell lung cancer and breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 42011-78-9
- Formula: C18H24O5
- Molecular Weight:320.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HSP90 2.3 μM (EC50) |
Caspase 3 |
HER2 25 μM (EC50) |
(Rac)-Zearalanone (SID: 855681) reduces Raf-1 levels and induces caspase-3 cleavage in NCI-N417 cells, and degrades Her2 in SKBr3 cells with an EC50 of 25 μM by inhibiting HSP90 function[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 42011-78-9
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Molecular Weight 320.38
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Formula C18H24O5
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SMILES
O=C1OC(CCCC(CCCCCC2=C1C(O)=CC(O)=C2)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(Rac)-Zearalanone Related Classifications
HY-N6678A Related Classifications
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