(Rac)-Zearalanone
(Rac)-Zearalanone is an ATP-competitive HSP90 inhibitor with an EC50 of 2.3 μM. (Rac)-Zearalanone interferes with the binding of ATP to HSP90, impairs the chaperone function of HSP90, and promotes the degradation of client proteins. (Rac)-Zearalanone reduces intracellular accumulation of Raf-1, induces cleavage of caspase-3, and promotes Her2 degradation in a dose-dependent manner by disrupting the Her2-HSP90 interaction. (Rac)-Zearalanone can be used in the research of small cell lung cancer and breast cancer.
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- CAS No.: 42011-78-9
- Formule: C18H24O5
- Masse moléculaire:320.38
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
IC50 & Target
[1]|
HSP90 2.3 μM (EC50) |
Caspase 3 |
HER2 25 μM (EC50) |
In Vitro
(Rac)-Zearalanone (SID: 855681) reduces Raf-1 levels and induces caspase-3 cleavage in NCI-N417 cells, and degrades Her2 in SKBr3 cells with an EC50 of 25 μM by inhibiting HSP90 function[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 42011-78-9
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Masse moléculaire 320.38
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Formule C18H24O5
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SMILES
O=C1OC(CCCC(CCCCCC2=C1C(O)=CC(O)=C2)=O)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(Rac)-Zearalanone Related Classifications
HY-N6678A Related Classifications
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