Regorafénib N-oxyde (M2)
Based on 1 Customer Validation
Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively.
For research use only. We do not sell to patients.
- Purity: 98.15%
- CAS No.: 835621-11-9
- Formula: C21H15ClF4N4O4
- Molecular Weight:498.81
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Chemical Information
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CAS No. 835621-11-9
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Appearance Solid
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Molecular Weight 498.81
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Formula C21H15ClF4N4O4
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Color White to light yellow
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SMILES
FC1=CC(OC2=CC=[N+]([O-])C(C(NC)=O)=C2)=CC=C1NC(NC3=CC(C(F)(F)F)=C(Cl)C=C3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
DMSO : 50 mg/mL (100.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0048 mL | 10.0239 mL | 20.0477 mL | 50.1193 mL |
| 5 mM | 0.4010 mL | 2.0048 mL | 4.0095 mL | 10.0239 mL | |
| 10 mM | 0.2005 mL | 1.0024 mL | 2.0048 mL | 5.0119 mL | |
| 15 mM | 0.1337 mL | 0.6683 mL | 1.3365 mL | 3.3413 mL | |
| 20 mM | 0.1002 mL | 0.5012 mL | 1.0024 mL | 2.5060 mL | |
| 25 mM | 0.0802 mL | 0.4010 mL | 0.8019 mL | 2.0048 mL | |
| 30 mM | 0.0668 mL | 0.3341 mL | 0.6683 mL | 1.6706 mL | |
| 40 mM | 0.0501 mL | 0.2506 mL | 0.5012 mL | 1.2530 mL | |
| 50 mM | 0.0401 mL | 0.2005 mL | 0.4010 mL | 1.0024 mL | |
| 60 mM | 0.0334 mL | 0.1671 mL | 0.3341 mL | 0.8353 mL | |
| 80 mM | 0.0251 mL | 0.1253 mL | 0.2506 mL | 0.6265 mL | |
| 100 mM | 0.0200 mL | 0.1002 mL | 0.2005 mL | 0.5012 mL |
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