AWL-II-38.3
Based on 1 Customer Validation
AWL-II-38.3 is a potent ephrin-A receptor (EphA3) kinase inhibitor. AWL-II-38.3 does not exhibit significant cellular activity against Src-family kinases nor against b-raf.
For research use only. We do not sell to patients.
- Purity: 99.68%
- CAS No.: 1135205-94-5
- Formula: C23H18F3N5O3
- Molecular Weight:469.42
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Chemical Information
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CAS No. 1135205-94-5
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Appearance Solid
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Molecular Weight 469.42
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Formula C23H18F3N5O3
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Color White to light yellow
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SMILES
O=C(C1=CC=NO1)NC2=CC(NC(C3=CC(C(F)(F)F)=CC(N4C=NC(C)=C4)=C3)=O)=CC=C2C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 100 mg/mL (213.03 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Yongmun Choi, et al. Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4467-70. [Content Brief]
[2]. Efrat Mashiach-Farkash, et al. Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton. Oncotarget. 2012 Jun;3(6):629-39. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1303 mL | 10.6514 mL | 21.3029 mL | 53.2572 mL |
| 5 mM | 0.4261 mL | 2.1303 mL | 4.2606 mL | 10.6514 mL | |
| 10 mM | 0.2130 mL | 1.0651 mL | 2.1303 mL | 5.3257 mL | |
| 15 mM | 0.1420 mL | 0.7101 mL | 1.4202 mL | 3.5505 mL | |
| 20 mM | 0.1065 mL | 0.5326 mL | 1.0651 mL | 2.6629 mL | |
| 25 mM | 0.0852 mL | 0.4261 mL | 0.8521 mL | 2.1303 mL | |
| 30 mM | 0.0710 mL | 0.3550 mL | 0.7101 mL | 1.7752 mL | |
| 40 mM | 0.0533 mL | 0.2663 mL | 0.5326 mL | 1.3314 mL | |
| 50 mM | 0.0426 mL | 0.2130 mL | 0.4261 mL | 1.0651 mL | |
| 60 mM | 0.0355 mL | 0.1775 mL | 0.3550 mL | 0.8876 mL | |
| 80 mM | 0.0266 mL | 0.1331 mL | 0.2663 mL | 0.6657 mL | |
| 100 mM | 0.0213 mL | 0.1065 mL | 0.2130 mL | 0.5326 mL |
AWL-II-38.3 Related Classifications
HY-18832 Related Classifications
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