AWL-II-38.3
Based on 1 Customer Validation
AWL-II-38.3 is a potent ephrin-A receptor (EphA3) kinase inhibitor. AWL-II-38.3 does not exhibit significant cellular activity against Src-family kinases nor against b-raf.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.68%
- CAS 番号: 1135205-94-5
- 分子式: C23H18F3N5O3
- 分子量:469.42
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
IC50 & Target
体外実験
化学情報
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CAS 番号 1135205-94-5
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性状 Solid
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分子量 469.42
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分子式 C23H18F3N5O3
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Color White to light yellow
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SMILES
O=C(C1=CC=NO1)NC2=CC(NC(C3=CC(C(F)(F)F)=CC(N4C=NC(C)=C4)=C3)=O)=CC=C2C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : ≥ 100 mg/mL (213.03 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Yongmun Choi, et al. Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4467-70. [Content Brief]
[2]. Efrat Mashiach-Farkash, et al. Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton. Oncotarget. 2012 Jun;3(6):629-39. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1303 mL | 10.6514 mL | 21.3029 mL | 53.2572 mL |
| 5 mM | 0.4261 mL | 2.1303 mL | 4.2606 mL | 10.6514 mL | |
| 10 mM | 0.2130 mL | 1.0651 mL | 2.1303 mL | 5.3257 mL | |
| 15 mM | 0.1420 mL | 0.7101 mL | 1.4202 mL | 3.5505 mL | |
| 20 mM | 0.1065 mL | 0.5326 mL | 1.0651 mL | 2.6629 mL | |
| 25 mM | 0.0852 mL | 0.4261 mL | 0.8521 mL | 2.1303 mL | |
| 30 mM | 0.0710 mL | 0.3550 mL | 0.7101 mL | 1.7752 mL | |
| 40 mM | 0.0533 mL | 0.2663 mL | 0.5326 mL | 1.3314 mL | |
| 50 mM | 0.0426 mL | 0.2130 mL | 0.4261 mL | 1.0651 mL | |
| 60 mM | 0.0355 mL | 0.1775 mL | 0.3550 mL | 0.8876 mL | |
| 80 mM | 0.0266 mL | 0.1331 mL | 0.2663 mL | 0.6657 mL | |
| 100 mM | 0.0213 mL | 0.1065 mL | 0.2130 mL | 0.5326 mL |
AWL-II-38.3 関連分類
HY-18832 関連分類
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