2. Metabolic Enzyme/Protease
  3. Ser/Thr Protease
  4. (E)-FOBISIN101

(E)-FOBISIN101 is a 14-3-3 protein-protein interaction (14-3-3 protein-protein interaction) inhibitor, with IC50 values of 9.3 and 16.4 μM for disrupting the binding of 14-3-3ζ or 14-3-3γ to PRAS40, respectively. (E)-FOBISIN101 inhibits the binding of 14-3-3 to Raf-1 and proline-rich AKT substrate, and neutralizes the ability of 14-3-3 to activate exotoxin S ADP-ribosyltransferase. (E)-FOBISIN101 is applicable to 14-3-3-mediated cancer research.

For research use only. We do not sell to patients.

(E)-FOBISIN101

(E)-FOBISIN101 Chemical Structure

CAS No. : 1370281-06-3

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(E)-FOBISIN101 Related Antibodies

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Description

(E)-FOBISIN101 is a 14-3-3 protein-protein interaction (14-3-3 protein-protein interaction) inhibitor, with IC50 values of 9.3 and 16.4 μM for disrupting the binding of 14-3-3ζ or 14-3-3γ to PRAS40, respectively. (E)-FOBISIN101 inhibits the binding of 14-3-3 to Raf-1 and proline-rich AKT substrate, and neutralizes the ability of 14-3-3 to activate exotoxin S ADP-ribosyltransferase. (E)-FOBISIN101 is applicable to 14-3-3-mediated cancer research[1].
IC50 & Target

14-3-3γ

16.4 μM (IC50)

13565

16.4 μM (IC50)

14-3-3ζ

9.3 μM (IC50)

13566

9.3 μM (IC50)

In Vitro

FOBISIN101 (5 mM; 3 days) forms a covalent adduct with Lys120 in purified 14-3-3ζ after X-ray radiation, occupying the peptide-binding groove and inactivating the protein[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(E)-FOBISIN101 Related Antibodies
Molecular Weight

461.21

Formula

C15H11N3Na3O8P
CAS No.
Appearance

Solid

Color

Brown to dark brown

SMILES

O=C(O[Na])C(C=C1)=CC=C1/N=N/C2=C(COP(O[Na])(O[Na])=O)C(C=O)=C(C(C)=N2)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: 95.63%

SDS (252 KB)

COA (257 KB) HNMR (227 KB) RP-HPLC (365 KB) LCMS (139 KB)

Handling Instructions (2659 KB)
References
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(E)-FOBISIN101 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E)-FOBISIN1011370281-06-3Ser/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasesPRAS40ExoS14-3-3 isoformslysine 12014-3-3ζADP-ribosyltransferasecancerCOS-7 cell lysates14-3-3γRaf-1Inhibitorinhibitorinhibit

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