(E)-FOBISIN101
Based on 1 Customer Validation
(E)-FOBISIN101 is a 14-3-3 protein-protein interaction (14-3-3 protein-protein interaction) inhibitor, with IC50 values of 9.3 and 16.4 μM for disrupting the binding of 14-3-3ζ or 14-3-3γ to PRAS40, respectively. (E)-FOBISIN101 inhibits the binding of 14-3-3 to Raf-1 and proline-rich AKT substrate, and neutralizes the ability of 14-3-3 to activate exotoxin S ADP-ribosyltransferase. (E)-FOBISIN101 is applicable to 14-3-3-mediated cancer research.
For research use only. We do not sell to patients.
- Purity: 95.63%
- CAS No.: 1370281-06-3
- Formula: C15H11N3Na3O8P
- Molecular Weight:461.21
-
Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
-
Metabolism/Protease Compound Library
HY-L012
-
Anti-Cancer Compound Library
HY-L025
-
Autophagy Compound Library
HY-L029
-
Coagulation and Anti-coagulation Compound Library
HY-L136
-
Cysteine Targeted Covalent Library
HY-L153
-
Multi-Target Compound Library
HY-L176
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
Protein Kinase Compound Library
HY-L196
-
High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
|
14-3-3γ |
14-3-3γ 16.4 μM (IC50) |
13565 16.4 μM (IC50) |
14-3-3ζ 9.3 μM (IC50) |
13566 9.3 μM (IC50) |
FOBISIN101 (5 mM; 3 days) forms a covalent adduct with Lys120 in purified 14-3-3ζ after X-ray radiation, occupying the peptide-binding groove and inactivating the protein[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 1370281-06-3
-
Appearance Solid
-
Molecular Weight 461.21
-
Formula C15H11N3Na3O8P
-
Color Brown to dark brown
-
SMILES
O=C(O[Na])C(C=C1)=CC=C1/N=N/C2=C(COP(O[Na])(O[Na])=O)C(C=O)=C(C(C)=N2)O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
-
Data Sheet (275 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz