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14-3-3γ Related Products (3)
Related Products (3)
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WS3
0 ImagesWS3 is an allosteric inhibitor of 14-3-3 (14-3-3ζ: Kd = 2.29 μM). WS3 activates GSK3β by disrupting the binding of 14-3-3-pGSK3β, promotes the ubiquitination and degradation of NRF2, and inhibits the NRF2-ARE signaling pathway (IC50 = 135 nM). It exerts antioxidant inhibition and chemotherapeutic/ferroptosis sensitizing effects in tumors with hyperactivated NRF2. WS3 binds to EBP1/IKKε and promotes the proliferation of β cells and retinal pigment epithelial (RPE) cells, which can be applied to islet regeneration and RPE expansion transplantation. WS3 is applicable to research related to age-related macular degeneration, retinal degeneration and non-small cell lung cancer.
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(E)-FOBISIN101
0 ImagesCat. No.: HY-115501CAS No.: 1370281-06-3(E)-FOBISIN101 is a 14-3-3 protein-protein interaction (14-3-3 protein-protein interaction) inhibitor, with IC50 values of 9.3 and 16.4 μM for disrupting the binding of 14-3-3ζ or 14-3-3γ to PRAS40, respectively. (E)-FOBISIN101 inhibits the binding of 14-3-3 to Raf-1 and proline-rich AKT substrate, and neutralizes the ability of 14-3-3 to activate exotoxin S ADP-ribosyltransferase. (E)-FOBISIN101 is applicable to 14-3-3-mediated cancer research.
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14-3-3γ/SLP76 stabilizer-1
0 ImagesCat. No.: HY-W678610CAS No.: 136715-68-914-3-3γ/SLP76 degrader-1 is a stabiliser of the 14-3-3γ/phosphorylated SLP76 protein-protein interaction. 14-3-3γ/SLP76 degrader-1 lacks stabilising activity on the unrelated IL17/IL17R protein-protein interaction. 14-3-3γ/SLP76 degrader-1 lacks stabilising activity on the 14-3-3ζ/p27 protein-protein interaction. 14-3-3γ/SLP76 degrader-1 can be used for the research of autoimmune and inflammatory conditions.
