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Cat. No.: HY-161760

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Ferroptosis inducer-3

Ferroptosis inducer-3 (compound JB3) is an oral bioactive inhibitor of RAF1, with the IC₅₀ of 226.9 nM. Ferroptosis inducer-3 can induce ferroptosis and plays an important role in cancer research.

For research use only. We do not sell to patients.

Formula: C₂₁H₁₅Cl₂F₃N₂O₃
Molecular Weight:471.26

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Ferroptosis inducer-3 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All Raf Isoforms :

Chemical Information

Molecular Weight 471.26
Formula C₂₁H₁₅Cl₂F₃N₂O₃
SMILES

ClC1=CC=C(NC(NC2=CC=C(OC3=CC=C(Cl)C=C3OC)C=C2)=O)C=C1C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yun-Jeong Kim, et al. Remodeling of sorafenib as an orally bioavailable ferroptosis inducer for Lung Cancer by chemical modification of adenine-binding motif. Biomed Pharmacother. 2024 Jul:176:116758. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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