2. GPCR/G Protein
    MAPK/ERK Pathway
  3. Ras
    Raf
  4. MCP110

MCP110 

Cat. No.: HY-123673 Purity: 99.82%
COA Handling Instructions

MCP110 is an inhibitor of Ras/Raf-1 interaction. MCP110 blocks the interaction of Ras with Raf. MCP110 disrupts this interaction might can be used for the research of human tumors.

For research use only. We do not sell to patients.

MCP110 Chemical Structure

MCP110 Chemical Structure

CAS No. : 521310-51-0

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 224 In-stock
Estimated Time of Arrival: December 31
Oil + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 224 In-stock
Estimated Time of Arrival: December 31
Oil
5 mg USD 200 In-stock
Estimated Time of Arrival: December 31
10 mg USD 350 In-stock
Estimated Time of Arrival: December 31
50 mg USD 950 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1350 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE MCP110

View All Ras Isoform Specific Products:

View All Isoforms
K-Ras H-Ras Ras

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BRaf c-Raf Raf

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MCP110 is an inhibitor of Ras/Raf-1 interaction. MCP110 blocks the interaction of Ras with Raf. MCP110 disrupts this interaction might can be used for the research of human tumors[1].

IC50 & Target[1]

Ras

 

RAF

 

In Vitro

MCP110 (10 and 20 uM) inhibits H-Ras (V12)-induced AP-1 activation in HEK293 cells. Ras stimulation of Raf-1 activity is significantly decreased by MCP110 (20 μM) [1].
MCP110 (1, 2, 5, 10, and 20 μM) shows a dose-dependent inhibition of elevated Raf-1 activity in fibrosarcoma HT1080 cells[1].
MCP110 (20 μM) decreases cyclin D level stimulated by the treatment with EGF (100 ng/mL), platelet-derived growth factor (20 ng/mL) , serum, or phorbol 12-myristate 13-acetate (100 nM) in A549 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

508.65

Appearance

Oil

Formula

C33H36N2O3
CAS No.
SMILES

O=C(N(CC1=CC=C(OCC2=CC=CC=C2)C(OC)=C1)CCC3=NC=CC=C3)CCCCC4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (491.50 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9660 mL 9.8299 mL 19.6599 mL
5 mM 0.3932 mL 1.9660 mL 3.9320 mL
10 mM 0.1966 mL 0.9830 mL 1.9660 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.09 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.09 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.82%

COA (247 KB) HNMR (301 KB) LCMS (267 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

MCP110521310-51-0MCP 110MCP-110RasRafRaf kinasesRaf-1colorectalcancerastrocytomasInhibitorinhibitorinhibit

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