KRAS - KRAS proto-oncogene, GTPase Gene
Also Known as NS; NS3; OES; CFC2; RALD; K-Ras; KRAS1; KRAS2; RASK2; KI-RAS; C-K-RAS; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; K-Ras 2; 'C-K-RAS; c-Ki-ras; c-Ki-ras2
Species: Homo sapiens
About KRAS
This gene has 14 transcripts (splice variants), 202 orthologues, 35 paralogues and is associated with 316 phenotypes. Ubiquitous expression in colon (RPKM 7.8), brain (RPKM 7.5) and 25 other tissues.
Summary
This gene, a Kirsten Ras oncogene homolog from the mammalian Ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]
KRAS Products (5)
| mRNA | Protein | Name |
|---|---|---|
| NM_001369787.1 | NP_001356716.1 | GTPase KRas isoform b |
| NM_033360.4 | NP_203524.1 | GTPase KRas isoform a |
| NM_004985.5 | NP_004976.2 | GTPase KRas isoform b |
| XM_047428826.1 | XP_047284782.1 | GTPase KRas isoform X1 |
| NM_001369786.1 | NP_001356715.1 | GTPase KRas isoform a |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables GTPase activity |
IMP
IMP: Inferred from mutant phenotype
|
26037647 | GOA |
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
26051715 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
10673434 | GOA |
| enables protein-containing complex binding |
IDA
IDA: Inferred from direct assay
|
23209302 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in positive regulation of gene expression |
IMP
IMP: Inferred from mutant phenotype
|
22065586 | GOA |
| involved in positive regulation of protein phosphorylation |
IMP
IMP: Inferred from mutant phenotype
|
22065586 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
23698361 | GOA |
| located in cytoplasmic side of plasma membrane |
IDA
IDA: Inferred from direct assay
|
23698361 | GOA |
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
28619714 | GOA |
KRAS Protein Structure
Ras: Ras family (5 - 164)
- 0
- 100
- 188 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
GTPase KRas |
|
|
KRAS Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
KRAS | P01116 | RAF1 | Homo sapiens | P04049 | 31980649 | |
|
Intra
|
KRAS | P01116 | RAF1 | Homo sapiens | P04049 | 30194290 | |
|
Intra
|
KRAS | P01116 | PIP5K1A | Homo sapiens | Q99755 | 30194290 | |
|
Intra
|
KRAS | P01116 | ARAF | Homo sapiens | Q96II5 | 25416956 | |
|
Intra
|
KRAS | P01116 | RASSF2 | Homo sapiens | P50749 | 12732644 | |
|
Intra
|
KRAS | P01116 | RASSF2 | Homo sapiens | P50749 | 12732644 |
Recombinant KRAS Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P7804 | Kras4B Protein, Human (184a.a, G12C, His) | AAH13572.1 (T2-C185, G12C) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P7805 | Kras4B Protein, Human (184a.a, G12V, His) | AAH13572.1 (T2-C185, G12V) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P70153 | Kras4B Protein, Human (G12S, His) | AAH13572.1 (T2-C185, G12S) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P70232 | Kras4B Protein, Human (G12C, His) | P01116-2 (M1-K169, G12C) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P70233 | Kras4B Protein, Human (His) | P01116-2 (M1-K169) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P70234 | Kras4B Protein, Human (G12V, His) | P01116-2 (M1-K169, G12V) | ≥ 95%, as determined by reducing SDS-PAGE. |
KRAS Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P86935 | KRAS Antibody (YA6628) | WB, IHC-P | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Urachus Cancer |
|
|
| Testicular Cancer |
|
|
| Rasopathy |
|
|
| Pulmonic Stenosis |
|
|
| Common Bile Duct Neoplasm |
|
|
| Cervical Cancer |
|
|
| Adenoma |
|
|
| Pulmonary Adenocarcinoma In Situ |
|
|
| Nemaline Myopathy 7 |
|
|
| Malignant Ovarian Surface Epithelial-Stromal Neoplasm |
|
|
| Thyroid Tumor |
|
|
| Duodenum Cancer |
|
|
| Respiratory System Benign Neoplasm |
|
|
| Cell Type Benign Neoplasm |
|
|
| Lung Sarcomatoid Carcinoma |
|
|
| Cystadenofibroma |
|
|
| Myoma |
|
|
| Rectosigmoid Junction Neoplasm |
|
|
| Pancreatic Signet Ring Cell Adenocarcinoma |
|
|
| Endometrioid Ovary Carcinoma |
|
|
| Familial Adenomatous Polyposis 2 |
|
|
| Mucinous Adenocarcinoma |
|
|
| Juvenile Myelomonocytic Leukemia |
|
|
| Fragile X Syndrome |
|
|
| Ampulla Of Vater Cancer |
|
|
| Papilloma |
|
|
| Mixed Cell Type Cancer |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Cholangitis, Primary Sclerosing |
|
|
| Ampulla Of Vater Adenocarcinoma |
|
|
| Gallbladder Disease |
|
|
| Uterine Carcinosarcoma |
|
|
| Pleomorphic Carcinoma |
|
|
| Villous Adenoma |
|
|
| In Situ Carcinoma |
|
|
| Pancreatic Cancer |
|
|
| Colon Adenoma |
|
|
| Costello Syndrome |
|
|
| Large Cell Carcinoma With Rhabdoid Phenotype |
|
|
| Colonic Disease |
|
|
| Teratoma |
|
|
| Lung Benign Neoplasm |
|
|
| Glioblastoma |
|
|
| Endometrial Adenocarcinoma |
|
|
| Rectal Benign Neoplasm |
|
|
| Rectal Disease |
|
|
| Autoimmune Lymphoproliferative Syndrome |
|
|
| Pulmonary Blastoma |
|
|
| Descending Colon Cancer |
|
|
| Uterine Corpus Cancer |
|
|
| Retinitis Pigmentosa |
|
|
| Pseudo-Turner Syndrome |
|
|
| Lung Giant Cell Carcinoma |
|
|
| Appendix Adenocarcinoma |
|
|
| Colonic Benign Neoplasm |
|
|
| Familial Adenomatous Polyposis |
|
|
| Mucinous Lung Adenocarcinoma |
|
|
| Skin Melanoma |
|
|
| Hydrops Fetalis, Nonimmune |
|
|
| Autism Spectrum Disorder |
|
|
| Biliary Tract Disease |
|
|
| Leukemia, Chronic Myeloid |
|
|
| Mucinous Intrahepatic Cholangiocarcinoma |
|
|
| Pilomyxoid Astrocytoma |
|
|
| Li-Fraumeni Syndrome |
|
|
| Ovarian Carcinosarcoma |
|
|
| Signet Ring Basal Cell Carcinoma |
|
|
| Exanthem |
|
|
| Lynch Syndrome |
|
|
| Appendix Disease |
|
|
| Sigmoid Neoplasm |
|
|
| Lung Carcinoma In Situ |
|
|
| Trachea Carcinoma In Situ |
|
|
| Pancreatic Cystadenocarcinoma |
|
|
| Melanoma, Uveal |
|
|
| Esophageal Cancer |
|
|
| Diffuse Gastric Cancer |
|
|
| Hereditary Breast Ovarian Cancer Syndrome |
|
|
| Cardiofaciocutaneous Syndrome 2 |
|
|
| Acneiform Dermatitis |
|
|
| Diffuse Gastric And Lobular Breast Cancer Syndrome |
|
|
| Skin Disease |
|
|
| Mucinous Cystadenocarcinoma |
|
|
| Cecum Adenocarcinoma |
|
|
| Lung Non-Squamous Non-Small Cell Carcinoma |
|
|
| Cholangiocarcinoma |
|
|
| Uterine Corpus Endometrial Carcinoma |
|
|
| Anus Cancer |
|
|
| Signet Ring Cell Adenocarcinoma |
|
|
| Pancreatic Acinar Cell Adenocarcinoma |
|
|
| Adenomyosis |
|
|
| Large Cell Neuroendocrine Carcinoma |
|
|
| Pancreatic Ductal Carcinoma |
|
|
| Ameloblastoma |
|
|
| Intrahepatic Cholangiocarcinoma |
|
|
| Thyroid Carcinoma, Familial Medullary |
|
|
| Ras-Associated Autoimmune Leukoproliferative Disorder |
|
|
| Leukemia, Chronic Lymphocytic |
|
|
| Rectum Adenocarcinoma |
|
|
| Hepatic Flexure Cancer |
|
|
| Acute Leukemia |
|
|
| Duodenum Disease |
|
|
| Papillary Adenoma |
|
|
| Sarcoma |
|
|
| Liver Angiosarcoma |
|
|
| Capillary Malformation-Arteriovenous Malformation 1 |
|
|
| Lung Large Cell Carcinoma |
|
|
| Wilms Tumor 1 |
|
|
| Rhabdomyosarcoma |
|
|
| Small Intestine Adenocarcinoma |
|
|
| Adenosquamous Carcinoma |
|
|
| Cardiofaciocutaneous Syndrome 1 |
|
|
| Hemangioma |
|
|
| Pancreatic Adenocarcinoma |
|
|
| Ovary Adenocarcinoma |
|
|
| Esophageal Atresia |
|
|
| Leukemia, Acute Lymphoblastic |
|
|
| Ovarian Serous Cystadenocarcinoma |
|
|
| Biliary Tract Benign Neoplasm |
|
|
| Ovarian Cancer |
|
|
| Hypertrophic Cardiomyopathy |
|
|
| Cervical Squamous Cell Carcinoma |
|
|
| Lung Cancer Susceptibility 3 |
|
|
| Intestinal Benign Neoplasm |
|
|
| Rectosigmoid Cancer |
|
|
| Acinar Cell Carcinoma |
|
|
| Ovarian Benign Neoplasm |
|
|
| Immature Teratoma Of Ovary |
|
|
| Myelodysplastic Syndrome |
|
|
| Ovary Epithelial Cancer |
|
|
| Bile Duct Disease |
|
|
| Gastric Adenocarcinoma |
|
|
| Endometrial Cancer |
|
|
| Breast Adenocarcinoma |
|
|
| Ethmoid Sinus Adenocarcinoma |
|
|
| Cecum Carcinoma |
|
|
| Pancreatic Ductal Adenocarcinoma |
|
|
| Neutropenia |
|
|
| Endometrial Mucinous Adenocarcinoma |
|
|
| Bile Duct Cysts |
|
|
| Ascending Colon Cancer |
|
|
| Noonan Syndrome-Like Disorder With Loose Anagen Hair 1 |
|
|
| Encephalocraniocutaneous Lipomatosis |
|
|
| Gastrointestinal System Benign Neoplasm |
|
|
| Angiosarcoma |
|
|
| Hepatocellular Carcinoma |
|
|
| Plasma Cell Neoplasm |
|
|
| Colorectal Adenoma |
|
|
| Nevus, Epidermal |
|
|
| Melanoma |
|
|
| Vaginal Carcinosarcoma |
|
|
| Melorheostosis |
|
|
| Gallbladder Cancer |
|
|
| Schimmelpenning-Feuerstein-Mims Syndrome |
|
|
| Neurofibromatosis |
|
|
| Papillary Serous Adenocarcinoma |
|
|
| Noonan Syndrome With Multiple Lentigines |
|
|
| Cervix Carcinoma |
|
|
| Female Reproductive Endometrioid Cancer |
|
|
| Adenofibroma |
|
|
| Struma Ovarii |
|
|
| Bladder Urachal Carcinoma |
|
|
| Leukemia, Acute Myeloid |
|
|
| Gastroesophageal Junction Adenocarcinoma |
|
|
| Colorectal Cancer |
|
|
| Papillary Adenocarcinoma |
|
|
| Basal Cell Carcinoma |
|
|
| Endosalpingiosis |
|
|
| Lung Cancer |
|
|
| Breast Cancer |
|
|
| Obstructive Jaundice |
|
|
| Pilocytic Astrocytoma |
|
|
| Rectum Cancer |
|
|
| Oculoectodermal Syndrome |
|
|
| Pancreatoblastoma |
|
|
| Differentiated Thyroid Carcinoma |
|
|
| Reproductive Organ Benign Neoplasm |
|
|
| Gastric Cancer |
|
|
| Pseudomyxoma Peritonei |
|
|
| Pre-Malignant Neoplasm |
|
|
| Carcinosarcoma |
|
|
| Bile Duct Cancer |
|
|
| Adenosquamous Lung Carcinoma |
|
|
| Klatskin'S Tumor |
|
|
| Pancreatic Mucinous Cystadenoma |
|
|
| Aplasia Cutis Congenita |
|
|
| Ovarian Mucinous Neoplasm |
|
|
| Noonan Syndrome And Noonan-Related Syndrome |
|
|
| Colorectal Adenocarcinoma |
|
|
| Ovarian Clear Cell Carcinoma |
|
|
| Cystadenocarcinoma |
|
|
| Lung Adenoma |
|
|
| Ampulla Of Vater Benign Neoplasm |
|
|
| Endometrial Hyperplasia |
|
|
| Thyroid Gland Cancer |
|
|
| Cardiovascular Organ Benign Neoplasm |
|
|
| Appendix Cancer |
|
|
| Bladder Cancer |
|
|
| Myeloma, Multiple |
|
|
| Bile Duct Adenocarcinoma |
|
|
| Transverse Colon Cancer |
|
|
| Renal Cell Carcinoma, Papillary, 1 |
|
|
| Duodenum Adenocarcinoma |
|
|
| Cowden Syndrome |
|
|
| Bronchiolo-Alveolar Adenocarcinoma |
|
|
| Adenoid Cystic Carcinoma |
|
|
| Bladder Urothelial Carcinoma |
|
|
| Adenocarcinoma |
|
|
| Arteriovenous Malformations Of The Brain |
|
|
| Mismatch Repair Cancer Syndrome |
|
|
| Nervous System Disease |
|
|
| Infiltrating Angiolipoma |
|
|
| Adenocarcinoma In Situ |
|
|
| Ovarian Cystadenocarcinoma |
|
|
| Endocervical Carcinoma |
|
|
| Lymphangioma |
|
|
| Prostate Cancer |
|
|
| Large Cell Carcinoma |
|
|
| Epilepsy |
|
|
| Appendiceal Neoplasm |
|
|
| Squamous Cell Carcinoma |
|
|
| Serous Cystadenocarcinoma |
|
|
| Gastroesophageal Adenocarcinoma |
|
|
| Neurofibromatosis, Type I |
|
|
| Germ Cell Cancer |
|
|
| Noonan Syndrome 1 |
|
|
| Microphthalmia |
|
|
| Periampullary Adenocarcinoma |
|
|
| Colon Adenocarcinoma |
|
|
| Anus Disease |
|
|
| Lung Squamous Cell Carcinoma |
|
|
| Small Intestine Cancer |
|
|
| Lipomatosis |
|
|
| Gastrointestinal Stromal Tumor |
|
|
| Malignant Exocrine Pancreas Neoplasm |
|
|
| Uterine Benign Neoplasm |
|
|
| Pancreatitis |
|
|
| Noonan Syndrome 3 |
|
|
| Peripheral Nervous System Disease |
|
|
| Gastrointestinal Carcinoma |
|
|
| Uterine Body Mixed Cancer |
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | KRAS | VGNC | VGNC:42508 |
| Mus musculus | KRAS | MGD | MGI:96680 |
| Rattus norvegicus | KRAS | RGD | RGD:2981 |
| Felis catus | KRAS | VGNC | VGNC:84048 |
| Macaca mulatta | KRAS | VGNC | VGNC:74205 |
| Bos taurus | KRAS | VGNC | VGNC:30710 |
| Others | KRAS | NCBI |