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  3. KRAS G12C inhibitor 44

KRAS G12C inhibitor 44 

Cat. No.: HY-142946
Handling Instructions

KRAS G12C inhibitor 44 (compound 54) is a potent and orally active KRAS G12C inhibitor. KRAS G12C inhibitor 44 shows anti-proliferation activities with IC50s of 0.016, 0.028 µM in MIA PaCA-2, H358 cells, respectively. KRAS G12C inhibitor 44 shows antitumor effects in vivo.

For research use only. We do not sell to patients.

KRAS G12C inhibitor 44 Chemical Structure

KRAS G12C inhibitor 44 Chemical Structure

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Description

KRAS G12C inhibitor 44 (compound 54) is a potent and orally active KRAS G12C inhibitor. KRAS G12C inhibitor 44 shows anti-proliferation activities with IC50s of 0.016, 0.028 µM in MIA PaCA-2, H358 cells, respectively. KRAS G12C inhibitor 44 shows antitumor effects in vivo[1].

IC50 & Target[1]

KRas G12C

 

Molecular Weight

579.11

Formula

C31H36ClFN6O2

SMILES

O=C(C(F)=C)N(CC1)[[email protected]@H](CC#N)CN1C2=NC(OC[[email protected]]3N(C)CCC3)=NC4=C2CC[[email protected]]5(C4)CCC6=C(Cl)C=CC=C65

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
KRAS G12C inhibitor 44
Cat. No.:
HY-142946
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