2927439-07-2
Chemical Structure
KRAS G12C inhibitor 44
- CAS No.: 2927439-07-2
- Formula:C31H36ClFN6O2
- Molecular Weight:579.11
IUPAC Name: 2-((S)-4-((R)-4-chloro-2'-(((S)-1-methylpyrrolidin-2-yl)methoxy)-2,3,5',8'-tetrahydro-6'H-spiro[indene-1,7'-quinazolin]-4'-yl)-1-(2-fluoroacryloyl)piperazin-2-yl)acetonitrile
InChIKey: LTBOVTGFAXPDLV-CYYCZYJVSA-N
SMILES: ClC1=C2C([C@]3(CC2)CC4=NC(OC[C@H]5N(CCC5)C)=NC(N6C[C@@H](N(CC6)C(C(F)=C)=O)CC#N)=C4CC3)=CC=C1
Biological Activity: KRAS G12C inhibitor 44 (compound 54) is a potent and orally active KRAS G12C inhibitor. KRAS G12C inhibitor 44 shows anti-proliferation activities with IC50s of 0.016, 0.028 µM in MIA PaCA-2, H358 cells, respectively. KRAS G12C inhibitor 44 shows antitumor effects in vivo[1].
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KRAS G12C inhibitor 44 | KRAS G12C inhibitor 44 (compound 54) is a potent and orally active KRAS G12C inhibitor. KRAS G12C inhibitor 44 shows anti-proliferation activities with IC50s of 0.016, 0.028 µM in MIA PaCA-2, H358 cells, respectively. KRAS G12C inhibitor 44 shows antitumor effects in vivo. | |||||||||||||||||||||
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